Jimmy Lin is developing technologies to catch cancer months to years before current methods. He shares a breakthrough technique that looks for small signals of cancer's presence via a simple blood test, detecting the recurrence of some forms of the disease 100 days earlier than traditional methods. It could be a ray of hope in a fight where early detection makes all the difference.

Loneliness doesn't always stem from being alone. For architect Grace Kim, loneliness is a function of how socially connected we feel to the people around us -- and it's often the result of the homes we live in. She shares an age-old antidote to isolation: cohousing, a way of living where people choose to share space with their neighbors, get to know them, and look after them. Rethink your home and how you live in it with this eye-opening talk.

Born with a genetic visual impairment that has no correction or cure, Susan Robinson is legally blind (or partially sighted, as she prefers it) and entitled to a label she hates: "disabled." In this funny and personal talk, she digs at our hidden biases by explaining five ways she flips expectations of disability upside down.

The divisiveness plaguing American politics today is nothing new, says constitutional law scholar Noah Feldman. In fact, it dates back to the early days of the republic, when a dispute between Alexander Hamilton and James Madison led the two Founding Fathers to cut ties and form the country's first political parties. Join Feldman for some fascinating history of American factionalism -- and a hopeful reminder about how the Constitution has proven itself to be greater than partisanship.

Why do so many companies make bad decisions, even with access to unprecedented amounts of data? With stories from Nokia to Netflix to the oracles of ancient Greece, Tricia Wang demystifies big data and identifies its pitfalls, suggesting that we focus instead on "thick data" -- precious, unquantifiable insights from actual people -- to make the right business decisions and thrive in the unknown.

Right now, billions of neurons in your brain are working together to generate a conscious experience -- and not just any conscious experience, your experience of the world around you and of yourself within it. How does this happen? According to neuroscientist Anil Seth, we're all hallucinating all the time; when we agree about our hallucinations, we call it "reality." Join Seth for a delightfully disorienting talk that may leave you questioning the very nature of your existence.

Climate change is real, case closed. But there's still a lot we don't understand about it, and the more we know the better chance we have to slow it down. One still-unknown factor: How might clouds play a part? There's a small hope that they could buy us some time to fix things ... or they could make global warming worse. Climate scientist Kate Marvel takes us through the science of clouds and what it might take for Earth to break its own fever.

What are our screens and devices doing to us? Psychologist Adam Alter studies how much time screens steal from us and how they're getting away with it. He shares why all those hours you spend staring at your smartphone, tablet or computer might be making you miserable -- and what you can do about it.

Rivers are one of nature's most powerful forces -- they bulldoze mountains and carve up the earth, and their courses are constantly moving. Understanding how they form and how they'll change is important for those that call their banks and deltas home. In this visual-packed talk, geoscientist Liz Hajek shows us how rocks deposited by ancient rivers can be used as a time machine to study the history of the earth, so we can figure out how to more sustainably live on it today.

It's a fateful moment in history. We've seen divisive elections, divided societies and the growth of extremism -- all fueled by anxiety and uncertainty. "Is there something we can do, each of us, to be able to face the future without fear?" asks Rabbi Lord Jonathan Sacks. In this electrifying talk, the spiritual leader gives us three specific ways we can move from the politics of "me" to the politics of "all of us, together."