Marc Vandermeer and John Harris preview the Houston Texans' 2025 season opener against the Los Angeles Rams with Hall of Fame football writer John McClain. The trio analyzes DeMeco Ryans' defensive schemes, C.J. Stroud's protection concerns with the revamped offensive line featuring rookie Aireontae Ersery, and Matthew Stafford's back injury impact. McClain breaks down key matchups including Will Anderson Jr. vs the Rams' pass protection, Nico Collins' target share with Christian Kirk's hamstring injury, and Nick Caley's new offense. Plus NFL predictions on the Bills, Jaguars, Ravens vs Chiefs, most overrated/underrated teams, and injury updates from Houston Methodist's Dr. Jason Awero. Essential listening for Texans fans ahead of the 3:25 PM kickoff at SoFi Stadium.

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