🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success.
🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸
🔗 Get your unique referral link here: refer.excedr.com/ZTHETY. 
Part 3 of 4: My guest today is Rafael Rosengarten, CEO and Co-Founder of Genialis, the RNA biomarker company. Genialis is reimagining biomarkers for every target, drug, and patient using a combination of precision oncology, RNA, and AI.
Rafael, a biomedical research veteran, combines academic excellence with industry innovation. A Dartmouth graduate with a Yale doctorate, he conducted postdoctoral research at Lawrence Berkeley National Laboratory, where he co-invented the j5 DNA assembly tool. As co-founder of the Alliance for AI in Healthcare, he advocates for responsible AI integration in medicine, drawing from his extensive background in evolution, immunology, bioengineering, and genetics.
In this episode, you'll hear about:

• Rafael’s move to Baylor College of Medicine and Houston’s vibrant medical community
• Innovations in molecular cloning and synthetic biology tools at Baylor
• Bridging biology and AI through collaborations with University of Ljubljana researchers
• Founding Genialis and shifting its focus to predictive biomarker development
• Lessons from biotech pivots that shaped Genialis as a leader in precision oncology

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!
Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Rafael Rosengarten, at these links: https://www.linkedin.com/in/rrosengarten/https://www.genialis.com/ 
Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ 
Enriched Notes:

Topics Mentioned:Baylor College of Medicine: https://www.bcm.edu/University of Ljubljana: https://www.uni-lj.si/en/universityGenialis: https://www.genialis.com/Lab Equipment List, Synthetic Biology Research: https://www.excedr.com/blog/lab-equipment-list-for-synthetic-biology-researchHow to Bootstrap Your Biotech Startup & Scale: https://www.excedr.com/resources/how-to-bootstrap-biotech-startupWhen & How to Pivot a Biotech Startup: https://www.excedr.com/blog/when-how-to-pivot-a-biotech-startupBiotech Startup Support Resources: https://www.excedr.com/resources-category/biotech-startup-supportThe Role of Machine Learning in Biotech: https://www.linkedin.com/pulse/machine-learning-biotech-fundamentals-divya-ramamoorthy-blhte/Predictive Biomarkers in Oncology: https://oncologypro.esmo.org/education-library/esmo-books/esmo-handbooks/translational-research/predictive-biomarkersAI and Omics Analysis in Cancer Research: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.588221/fullCollaborative Biotech Partnerships: https://www.excedr.com/blog/how-biotech-partnerships-support-research
People Mentioned:Gad Shaulsky: https://www.bcm.edu/people-search/gad-shaulsky-30425Adam Kuspa: https://www.linkedin.com/in/adam-kuspa-23bab836/Blaž Zupan: https://www.bcm.edu/people-search/blaz-zupan-33768Marinka Zitnik: https://www.linkedin.com/in/marinkaz/Miha Štajdohar: https://www.linkedin.com/in/mstajdohar/?originalSubdomain=siLaura Benjamin: https://www.linkedin.com/in/laura-e-benjamin-04299b34/

Timestamps:00:00 Intro02:11 Rafael’s move to Houston and postdoc at Baylor College of Medicine04:09 Collaborating with mentors and early breakthroughs in molecular cloning07:01 Joining the Gulf Coast Consortium and blending bench science with computational tools09:44 Transformative partnership with AI pioneers from the University of Ljubljana13:30 How early machine learning tools shaped Rafael’s career and perspective17:04 Founding Genialis and the early challenges of pivoting its focus19:59 Learning from failures and how they shaped Genialis’ mission23:21 The role of predictive biomarkers in oncology and their real-world impact27:59 Lessons learned from biotech pivots and navigating the startup world31:16 OutroThe Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success.
🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸
🔗 Get your unique referral link here: refer.excedr.com/ZTHETY. 

Part 2 of 4: My guest today is Rafael Rosengarten, CEO and Co-Founder of Genialis, the RNA biomarker company. Genialis is reimagining biomarkers for every target, drug, and patient using a combination of precision oncology, RNA, and AI.
Rafael, a biomedical research veteran, combines academic excellence with industry innovation. A Dartmouth graduate with a Yale doctorate, he conducted postdoctoral research at Lawrence Berkeley National Laboratory, where he co-invented the j5 DNA assembly tool. As co-founder of the Alliance for AI in Healthcare, he advocates for responsible AI integration in medicine, drawing from his extensive background in evolution, immunology, bioengineering, and genetics.
In this episode, you'll hear about:

• Rafael's graduate studies at Yale, where mentors fostered his independent research approach
• His diverse marine biology and genomics projects, preparing him for synthetic biology
• Rafael's transition to the Joint BioEnergy Institute (JBEI) for synthetic biology and biofuels research
• The collaborative environment at JBEI, including access to cutting-edge technology and bioinformatics tool development
• Rafael's insights on choosing the right lab environment and the growing acceptance of entrepreneurship in academia
  
  

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!
Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Rafael Rosengarten, at these links: https://www.linkedin.com/in/rrosengarten/https://www.genialis.com/ 
Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ 
Enriched Notes:

Topics Mentioned:Yale https://www.yale.edu/ Joint BioEnergy Institute (JBEI) https://www.jbei.org/ Next-Generation Sequencing https://www.excedr.com/blog/next-generation-sequencing-101 How to Spin Out of Academia & Into a Startup https://www.excedr.com/resources/how-to-spin-out-of-academia-and-into-a-startup What Should Investors & Founders Expect From Each Other https://www.excedr.com/resources/investor-founder-expectations How to Fund an R&D Startup https://www.excedr.com/resources/rd-startup-funding-first-steps 
People Mentioned:Stephen Dellaporta https://www.linkedin.com/in/stephen-dellaporta-442aa611/ Leo Buss https://eeb.yale.edu/people/faculty/leo-bussBarbara McClintock https://en.wikipedia.org/wiki/Barbara_McClintock Christopher Mason https://www.linkedin.com/in/christopher-mason-4972a119/ Jonathan Rothberg https://www.linkedin.com/in/jonathanrothberg/ Jay Keasling https://www.linkedin.com/in/jay-keasling-6783754/ Nathan Hillson https://www.linkedin.com/in/nathan-hillson-73702915/ 
Timestamps:00:00 - Intro02:56 - Rafael's experience with his graduate advisors and diverse research projects07:45 - Comparison of grad school experience to company building and board members08:59 - Discussion about Jonathan Rothberg and sequencing developments at Yale10:06 - Rafael's transition from Yale to the Joint BioEnergy Institute (JBEI)12:46 - The importance of showing up and making connections in person16:39 - The value of face-to-face interactions in business and collaboration20:19 - Challenges in the biotech market and the need for in-person networking23:11 - Rafael's work at JBEI in synthetic biology and tool development28:22 - Key takeaways from Rafael's experience at JBEI30:25 - The importance of entrepreneurship in academia and industry33:55 - OutroThe Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

Part 1 of 4: My guest today is Rafael Rosengarten, CEO and Co-Founder of Genialis, the RNA biomarker company. Genialis is reimagining biomarkers for every target, drug, and patient using a combination of precision oncology, RNA, and AI.
Rafael, a biomedical research veteran, combines academic excellence with industry innovation. A Dartmouth graduate with a Yale doctorate, he conducted postdoctoral research at Lawrence Berkeley National Laboratory, where he co-invented the j5 DNA assembly tool. As co-founder of the Alliance for AI in Healthcare, he advocates for responsible AI integration in medicine, drawing from his extensive background in evolution, immunology, bioengineering, and genetics.
In this episode, you'll hear about:

• Rafael's upbringing in rural South Carolina, influenced by his parents' intellectual hippie activist background and nature
• How his French cell biologist uncle sparked his love for science through snorkeling 
• Rafael's journey at Dartmouth, initially pursuing chemistry but ultimately finding his passion in evolutionary biology and ecology
• His post-college experiences alternating between scientific research and culinary pursuits
• The pivotal decision to attend a marine biology program at Friday Harbor instead of accepting an offer to cook on a private yacht
  
  

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!
Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Rafael Rosengarten, at these links: https://www.linkedin.com/in/rrosengarten/https://www.genialis.com/ 
Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ 
Enriched Notes: 

Topics Mentioned:Dartmouth https://home.dartmouth.edu/ Bay Wolf https://www.berkeleyside.org/2015/07/01/oaklands-bay-wolf-restaurant-closing-after-40-years Yale https://www.yale.edu/ Chez Panisse https://www.chezpanisse.com/1/ Friday Harbor Laboratories https://fhl.uw.edu/ 
People Mentioned:Jay Keasling https://www.linkedin.com/in/jay-keasling-6783754/ Mark McPeak https://biology.dartmouth.edu/people/mark-alan-mcpeek David Peart https://www.linkedin.com/in/david-peart-251787302/ Carol Folt https://biology.dartmouth.edu/people/carol-l-folt Leo Buss https://eeb.yale.edu/people/faculty/leo-buss Alice Waters https://en.wikipedia.org/wiki/Alice_Waters Fanny Singer (Waters) https://thefoldmag.com/arts-culture/a-conversation-with-fanny-singer-about-her-mother-daughter-memoir-always-home Jeremiah Tower https://www.linkedin.com/in/jeremiah-tower/ Dan Barber https://en.wikipedia.org/wiki/Dan_Barber Thomas Keller https://en.wikipedia.org/wiki/Thomas_Keller 
Timestamps:00:49 Intro02:48 Rafael's upbringing in rural South Carolina and early influences05:50 Discussing the impact of Rafael's upbringing on his business philosophy07:44 Rafael's decision to attend Dartmouth College10:27 Family influence on Rafael's academic pursuits12:04 Rafael's experiences at Dartmouth and choosing his major14:30 Summer internship at Bay Wolf restaurant in Oakland16:55 Influential professors and classmates at Dartmouth18:22 Post-graduation experiences and working at Yale23:20 Comparing cooking experiences on the West Coast and East Coast26:38 Entering Yale's biomedical program and the Friday Harbor experience29:48 OutroThe Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

Part 4 of 4: My guest today is Cyriac Roeding, founder, investor, and CEO of Earli, a company on a mission to transform cancer into a manageable condition. Using innovative gene therapy approaches, Earli’s technology forces cancer cells to produce a synthetic, non-human biomarker—overcoming the limitations of relying on naturally occurring biomarkers that cancer may or may not provide. 
Cyriac is a serial entrepreneur and investor who has created ventures at the intersection of physical and digital worlds. He has invested in startups like OpenAI and served as CEO of Shopkick, which was acquired for $250 million. His current focus, Earli, has raised nearly $60 million from top investors. Cyriac's journey from launching his first startup at 15 to being named a World Economic Forum Tech Pioneer showcases his valuable insights into building successful startups.
In this episode, you’ll hear about:

• How a Thanksgiving article about Dr. Sam Gambhir inspired the founding of Earli
• Earli’s groundbreaking approach to revolutionizing cancer detection using synthetic biology
• The challenges of translating scientific discoveries into real-world clinical applications
• Overcoming obstacles and achieving breakthroughs in diagnostics and therapeutics
• Cyriac’s unwavering commitment to transforming cancer into a manageable condition

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!
Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Cyriac Roeding, at these links: https://www.linkedin.com/in/cyriacroeding/https://www.earli.com/ https://www.joinrewind.com/ 
Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ 
Enriched Notes:

Topics Mentioned:Earli: https://www.earli.com/ Stanford University: https://www.stanford.edu/Andreessen Horowitz: https://a16z.com/Marc Benioff: https://www.linkedin.com/in/marcbenioff/Khosla Ventures: https://www.khoslaventures.com/Lab Equipment List, Synthetic Biology Research: https://www.excedr.com/blog/lab-equipment-list-for-synthetic-biology-researchHow to Bootstrap Your Biotech Startup & Scale: https://www.excedr.com/resources/how-to-bootstrap-biotech-startupWhen & How to Pivot a Biotech Startup: https://www.excedr.com/blog/when-how-to-pivot-a-biotech-startupHow to Craft a Pitch Deck for Biotech Investors: https://www.excedr.com/resources/how-to-craft-a-pitch-deck-for-biotech-investorsTop VC Firms for Biotech in 2024: https://www.excedr.com/blog/top-vc-firms-for-biotechBiotech Startup Support Resources: https://www.excedr.com/resources-category/biotech-startup-support
People Mentioned:Dr. Sam Gambhir: https://en.wikipedia.org/wiki/Sanjiv_Sam_GambhirDavid Suhy: https://www.linkedin.com/in/davidsuhy/Jorge Conde: https://www.linkedin.com/in/jorge-conde-4099225/Jim Allison: https://faculty.mdanderson.org/profiles/james_allison.htmlPam Sharma: https://faculty.mdanderson.org/profiles/padmanee_sharma.htmlPhil Greenberg: https://www.fredhutch.org/en/faculty-lab-directory/greenberg-philip.html
Timestamps:00:00 Intro02:08 How a Thanksgiving article about Dr. Sam Gambhir inspired Earli’s founding05:43 Meeting Dr. Gambhir and learning biology as a non-scientist entrepreneur09:02 Discovering the “one idea” that led to Earli’s revolutionary synthetic biology approach12:54 Earli’s mission to transform cancer detection and diagnostics17:30 Overcoming major challenges and achieving breakthroughs in diagnostics accuracy21:54 The emotional and scientific legacy of Dr. Gambhir and its impact on Earli’s vision26:28 Earli’s innovative approach to bridging diagnostics and therapeutics30:05 The business potential of Earli’s platform for cancer and other diseases33:04 Cyriac’s advice on taking the road less traveled as an entrepreneur35:41 OutroThe Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

Part 3 of 4: My guest today is Cyriac Roeding, founder, investor, and CEO of Earli, a company on a mission to transform cancer into a manageable condition. Using innovative gene therapy approaches, Earli’s technology forces cancer cells to produce a synthetic, non-human biomarker—overcoming the limitations of relying on naturally occurring biomarkers that cancer may or may not provide. 
Cyriac is a serial entrepreneur and investor who has created ventures at the intersection of physical and digital worlds. He has invested in startups like OpenAI and served as CEO of Shopkick, which was acquired for $250 million. His current focus, Earli, has raised nearly $60 million from top investors. Cyriac's journey from launching his first startup at 15 to being named a World Economic Forum Tech Pioneer showcases his valuable insights into building successful startups.
In this episode, you’ll hear about:

• Launching Shopkick during the 2008 financial crisis and securing funding against the odds
• Partnering with Best Buy, Macy’s, and Target to pioneer in-store rewards using ultrasound technology
• Overcoming GPS limitations with innovative hardware solutions
• Switching from retail tech to life sciences, with a focus on AI and engineering
• Cyriac’s vision for digital clinical trials to accelerate drug development

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!
Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Cyriac Roeding, at these links: https://www.linkedin.com/in/cyriacroeding/https://www.earli.com/ https://www.joinrewind.com/ 
Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ 

Enriched Notes:

Topics Mentioned:Earli: https://www.earli.com/ Kleiner Perkins: https://en.wikipedia.org/wiki/Kleiner_Perkins Shopkick: https://en.wikipedia.org/wiki/Shopkick AI in Drug Development & Clinical Trials: https://www.earli.com/post/how-ai-is-powering-earlis-missionBiotech Startup Support: https://www.excedr.com/resources-category/biotech-startup-support
People Mentioned:John Doerr: https://www.linkedin.com/in/john-doerr-03248211/Steve Jobs: https://en.wikipedia.org/wiki/Steve_JobsReid Hoffman: https://www.linkedin.com/in/reidhoffman/Aaron Emigh: https://www.linkedin.com/in/aaronemigh/Alexis Rask: https://www.linkedin.com/in/aleinoff/
Timestamps:00:00 Intro01:58 Joining Kleiner Perkins as an entrepreneur-in-residence05:43 Developing the idea for Shopkick08:20 Securing Best Buy as a partner and navigating retailer challenges11:11 Using ultrasound technology to solve GPS limitations for in-store tracking13:25 Partnering with major brands and scaling Shopkick to profitability16:25 Transitioning to life sciences and shifting focus to biology and AI20:18 Exploring the potential of digital clinical trials24:05 The intersection of biology, engineering, and software as the next frontier27:57 Cyriac’s vision for the future of drug development31:30 OutroThe Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success.
🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸
🔗 Get your unique referral link here: refer.excedr.com/ZTHETY. 
Part 2 of 4: My guest today is Cyriac Roeding, founder, investor, and CEO of Earli, a company on a mission to transform cancer into a manageable condition. Using innovative gene therapy approaches, Earli’s technology forces cancer cells to produce a synthetic, non-human biomarker—overcoming the limitations of relying on naturally occurring biomarkers that cancer may or may not provide. 
Cyriac is a serial entrepreneur and investor who has created ventures at the intersection of physical and digital worlds. He has invested in startups like OpenAI and served as CEO of Shopkick, which was acquired for $250 million. His current focus, Earli, has raised nearly $60 million from top investors. Cyriac's journey from launching his first startup at 15 to being named a World Economic Forum Tech Pioneer showcases his valuable insights into building successful startups.
In this episode, you’ll hear about:

• How Cyriac's early fascination with technology manifested through building a digital clock from scratch
• The transformative experience in Tokyo that served as a "reset button," exposing him to radical cultural differences
• His strategic career progression from Roland Berger to McKinsey
• The pivotal move from a failing mobile auction business to pioneering "mobile marketing" 
• The challenging transition to CBS Mobile, where starting from zero employees allowed him to leapfrog competitors by implementing innovative features 
  
  

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!
LinksSubscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Cyriac Roeding, at these links: https://www.linkedin.com/in/cyriacroeding/https://www.earli.com/ https://www.joinrewind.com/ 
Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/

Enriched Notes: 

Topics Mentioned:Earli Inc https://www.earli.com/ Roland Berger https://en.wikipedia.org/wiki/Roland_Berger_(company) McKinsey https://en.wikipedia.org/wiki/McKinsey_%26_Company CBS https://en.wikipedia.org/wiki/CBS 
People Mentioned:Chris Burggraeve https://www.linkedin.com/in/chrisburggraeve/ David Katz https://www.linkedin.com/in/davidakatz1/ Nancy Tellem https://www.linkedin.com/in/nancy-tellem-5a3b8311/ 
Timestamps:00:00 Introduction and recap of previous episode with Cyriac Roeding02:06 Cyriac's experience moving to Japan and cultural observations03:58 Early technology interests: building digital clocks and programming robots07:44 Discussion on trial and error in business and innovation09:21 First job experiences at Roland Berger consulting in Tokyo and Munich12:14 Journey to McKinsey and writing "The Secrets of Software Success"14:09 First visit to Silicon Valley and falling in love with the entrepreneurial spirit16:20 Starting a mobile technology company during the dot-com era20:26 Success with Coca-Cola mobile marketing campaign and company profitability22:01 Moving to CBS and initial challenges in Los Angeles25:06 Building CBS Mobile strategy and innovative mobile initiatives27:06 World travels observing mobile phone usage across different cultures29:52 OutroThe Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success.
🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸
🔗 Get your unique referral link here: refer.excedr.com/ZTHETY. 
Part 1 of 4: My guest today is Cyriac Roeding, founder, investor, and CEO of Earli, a company on a mission to transform cancer into a manageable condition. Using innovative gene therapy approaches, Earli’s technology forces cancer cells to produce a synthetic, non-human biomarker—overcoming the limitations of relying on naturally occurring biomarkers that cancer may or may not provide. 
Cyriac is a serial entrepreneur and investor who has created ventures at the intersection of physical and digital worlds. He has invested in startups like OpenAI and served as CEO of Shopkick, which was acquired for $250 million. His current focus, Earli, has raised nearly $60 million from top investors. Cyriac's journey from launching his first startup at 15 to being named a World Economic Forum Tech Pioneer showcases his valuable insights into building successful startups.
In this episode, you’ll hear about:

• How Cyriac's entrepreneurial journey began at age 8 selling at flea markets, leading to selling his first computer program at 15 to a newspaper company
• His transformative exchange year in Texas at age 16 and how it allowed Cyriac to reset his identity
• How his graduation event transformed his school into a beach with Coca-Cola sponsorship and TV coverage
• How he created and hosted a late-night radio show, balancing academic demands with creative pursuits
• How his experience studying in Japan revealed valuable lessons about cultural perspectives
  
  

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!

Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Cyriac Roeding, at these links: https://www.linkedin.com/in/cyriacroeding/https://www.earli.com/ https://www.joinrewind.com/ 
Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ 
Enriched Notes:

Topics Mentioned:Earli Inc https://www.earli.com/ Karlsruhe Institute of Technology https://www.kit.edu/english/index.php 
People Mentioned:Marc Benioff https://www.linkedin.com/in/marcbenioff/ 

Timestamps:
00:00 Intro03:06 Early life in Germany and first entrepreneurial experiences at local flea markets05:03 First job experience at a newspaper company and selling software at age 1508:59 Exchange student experience in Texas and transformation from German school life10:52 Life with host families in Texas and personal growth14:29 Return to Germany and fresh start at a new school16:31 Early business ventures, teaching computer skills and running a company at 1720:14 High school graduation and organizing a Coca-Cola sponsored beach event21:37 University decisions and pursuing industrial engineering at Karlsruhe Institute of Technology26:54 Journey to studying in Japan and securing a scholarship30:44 Cultural lessons in Japan: experiencing different value systems and problem-solving approaches36:30 Outro
The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

🧬 The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success.
🔬 Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸
🔗 Get your unique referral link here: refer.excedr.com/ZTHETY. 
Part 4 of 4: In this episode, Jon Chee hosts Kate Neville, PhD, Partner at Marshall Gerstein—a law firm with over 60 years of expertise in delivering sophisticated intellectual property advice and legal services to leading businesses, research institutions, universities, and entrepreneurs worldwide.
Kate is an accomplished attorney with a doctoral background in microbiology and immunology who specializes in global patent prosecution and strategic management. She has over a decade of experience, and works with a wide range of clients, from biotech startups to big pharma to non-profits. 
Kate has been recognized as a "World's Leading Patent Practitioner" by IAM magazine since 2013, an Illinois Super Lawyer since 2018, and is included in The Best Lawyers in America© for Patent Law.
In this episode, you’ll hear about:

• Why securing a patent is only the first step in IP protection
• Weighing litigation versus licensing to safeguard your IP
• Leveraging technology transfer and academic collaborations for innovation
• Driving innovation through incremental advancements in your IP portfolio
• Kate’s journey from scientist to partner, with insightful advice for those navigating career transitions

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!
Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Kate Neville, at these links: https://www.linkedin.com/in/kate-neville-phd/ https://www.marshallip.com/ 
Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ 
Enriched Notes:

Topics Mentioned:Marshall Gerstein: https://www.marshallip.com/IP Enforcement Strategies: https://www.wipo.int/en/web/ip-enforcement/IP Strategies for Biotechs: https://www.excedr.com/resources/intellectual-property-strategy-for-biotechsIP Rights to Understand: https://www.excedr.com/resources/intellectual-property-rights-for-biotechsIntellectual Property 101: https://www.excedr.com/resources/intellectual-property-guideTech Transfer 101: https://www.excedr.com/blog/what-is-tech-transferPatent Licensing 101: https://www.excedr.com/resources/how-patent-licensing-worksGuide to Life Sciences Licensing: https://www.excedr.com/blog/life-sciences-licensing-agreements-guideBiotech Startup Support: https://www.excedr.com/resources-category/biotech-startup-support
Timestamps:00:00 Intro02:04 The challenges of enforcing IP protections03:46 Balancing litigation and licensing as a business decision07:13 Technology transfer breakdown and how to secure your next big idea09:07 Exploring shelved pharma compounds as IP opportunities11:29 Avoiding common IP pitfalls for biotech startups14:10 The value of fresh perspectives in biotech entrepreneurship16:35 Challenges of transitioning from the bench to law practice20:52 Insights into life as a partner in an IP law firm23:09 2-year vision at Marshall Gerstein26:42 Closing questions and advice for biotech founders29:47 OutroThe Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

🧬The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success.
🔬Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸
🔗Get your unique referral link here: refer.excedr.com/ZTHETY. 
Part 3 of 4: In this episode, Jon Chee hosts Kate Neville, PhD, Partner at Marshall Gerstein—a law firm with over 60 years of expertise in delivering sophisticated intellectual property advice and legal services to leading businesses, research institutions, universities, and entrepreneurs worldwide.
Kate is an accomplished attorney with a doctoral background in microbiology and immunology who specializes in global patent prosecution and strategic management. She has over a decade of experience, and works with a wide range of clients, from biotech startups to big pharma to non-profits. 
Kate has been recognized as a "World's Leading Patent Practitioner" by IAM magazine since 2013, an Illinois Super Lawyer since 2018, and is included in The Best Lawyers in America© for Patent Law.
In this episode, you’ll hear about:

• Building a strong foundation for your IP and the importance of well-crafted provisional applications.
• Aligning scientific advancements with proactive patent strategies to maximize long-term value.
• The critical timing for startups to address IP concerns, from tech transfer to scaling operations.
• The nuances of international patenting and strategic decisions on global protections.
• Practical tips for founders on prioritizing IP investments to strengthen their company and attract investors.
  
  

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening!
Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Kate Neville, at these links: https://www.linkedin.com/in/kate-neville-phd/ https://www.marshallip.com/ 

Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ 
Enriched Notes:

Topics Mentioned:Marshall Gerstein: https://www.marshallip.com/Intellectual Property 101: https://www.excedr.com/resources/intellectual-property-guideHow to Protect Your IP in the Life Sciences: https://www.excedr.com/resources/how-to-protect-your-intellectual-propertyIP Strategy for Biotechs: https://www.excedr.com/resources/intellectual-property-strategy-for-biotechsUnderstanding IP Rights for Biotechs: https://www.excedr.com/resources/intellectual-property-rights-for-biotechsPatent Licensing 101: https://www.excedr.com/resources/how-patent-licensing-worksResources for Biotech Startups: https://www.excedr.com/resources/
Timestamps:00:00 Intro
02:09 How to approach intellectual property (IP) as a biotech startup05:06 When to start thinking about your IP portfolio and strategy08:52 How much time does it take to protect your IP, and what are the phases?11:26 Some best practices for global IP protections14:07 Importance of patents to investors, and the timing behind raising capital15:54 How does IP strategy differ from company to company?17:37 Patent offices’ outlook on broad platform protections22:18 Thought process behind picking which IP to hold or sell25:01 Fundamental aspects of a solid IP strategy29:08 OutroThe Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

🧬The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success.
🔬Know someone in need of lab equipment? Join Excedr’s referral program: Give your friends $1,000 and earn $1,000 for every qualified referral! 💸
🔗Get your unique referral link here: refer.excedr.com/ZTHETY. 
Part 2 of 4: Jon Chee hosts Kate Neville, Partner at Marshall Gerstein—a law firm with over 60 years of expertise in delivering sophisticated intellectual property advice and legal services to leading businesses, research institutions, universities, and entrepreneurs worldwide.
Kate, an accomplished attorney with a doctoral background in microbiology and immunology, specializes in global patent prosecution and strategic management. With over a decade of experience, she works with biotech startups, big pharma, and non-profits. Kate has been recognized as a "World's Leading Patent Practitioner" by IAM magazine since 2013, an Illinois Super Lawyer since 2018, and is included in The Best Lawyers in America© for Patent Law.
Join us this week to hear about:

• Kate's transition from patent agent to lawyer, highlighting challenges of pursuing a law degree while working full-time
• The culture shock scientists face in law school, adjusting to ambiguity and lack of definitive answers
• The extensive reading required in law school compared to scientific literature, requiring a different approach
• The collegial culture at Kate's law firm, fostering an environment where former scientists can thrive
• How patent law work provides exposure to diverse scientific fields, offering continuous learning opportunities

Please enjoy Jon’s conversation with Kate Neville.
Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994
Find Our Guest, Kate Neville, at these links: https://www.linkedin.com/in/kate-neville-phd/ https://www.marshallip.com/ 
Find Our Host, Jon Chee, at these links: https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/ 
Enriched Notes:

Topics Mentioned:Marshall, Gerstein & Borun https://www.marshallip.com/ 
Business Entities & Their Differences https://www.excedr.com/resources/what-are-the-differences-between-business-entities Intellectual Property 101: Types & Uses https://www.excedr.com/resources/intellectual-property-guide How to Protect Your Intellectual Property in the Life Sciences https://www.excedr.com/resources/how-to-protect-your-intellectual-property 
Timestamps:00:00 Intro02:24 Kate discusses taking the patent bar and transitioning from patent agent to pursuing law school04:14 Experience of working full-time while attending law school at night06:56 Challenges scientists face when transitioning to law school, particularly dealing with ambiguity09:28 Discussion about the different types of reading required in law school versus scientific papers12:20 Kate describes her law firm's culture and what made her stay throughout her career16:02 Benefits of having broad scientific knowledge and crossdisciplinary experience18:49 Working with scientist clients and keeping up with evolving technologies20:05 OutroThe Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.