The Biotech Startups Podcast

The Biotech Startups Podcast

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The Biotech Startups Podcast episodes

  • 🧬 Care Before You Share: Sales, Science & the PhD Ultra-Marathon | Mike Stadnisky Rerelease (Part 1/3)
    🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.
    As a TBSP listener, you can get exclusive perks through Excedr's partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners
    "I always joke — I got my MBA from my dad before I ever even considered what the heck I wanted to do with it."
    In this episode of The Biotech Startups Podcast, Jon Chee sits down with Mike Stadnisky, Managing Director of Thielsen Capital — a seed-stage life science tools syndicate. Before Thielsen, Mike was CEO of Phytonix (acquired by Thermo Fisher) and FlowJo (acquired by BD Life Sciences), and has taught at MIT Sloan. In Part 1, Mike traces his path from growing up with a chemical engineer father who gave him early exposure to business strategy, to studying biochemistry at Clemson, to working as a Red Bull Student Brand Manager — a role that shaped his enduring "care before you share" philosophy: meeting people where they are, not where it's convenient. He carried that mindset into grad school at UVA, where he joined Michael Brown's lab to study NK cells and innate immunity, fell in love with flow cytometry, and had his first (tearful) encounter with FlowJo.
    Key Topics Covered:
    • Business at the Dinner Table: How his chemical engineer father gave him an early, unfiltered business education
    • Red Bull Brand Manager: Lessons in authentic connection and meeting people in their "moment of need"
    • Biochemistry at Clemson: How a high school biology-chemistry program and Gattaca locked in his life science path
    • Choosing Brown's Lab at UVA: Why lab culture matters as much as the science, and how small labs mirror startups
    • NK Cells & Flow Cytometry: His PhD research focus and the origin story of a tools obsession that defined his career
    • The PhD as an Ultra-Marathon: Why sustainable effort beats sprinting, and how grad school stress-tests you for every business ahead

    If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.
    Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994 Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4 YouTube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ 
    Find our guest, Mike Stadnisky at these links:LinkedIn: https://www.linkedin.com/in/mikestadnisky/ Website: https://www.thielsencapital.com/ 
    Find our host, Jon Chee, at these links:LinkedIn: https://www.linkedin.com/in/jonchee/ 
    Learn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com 
    Intro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin

    Resources & Articles:What Is Flow Cytometry & How Do Flow Cytometers Work?: https://www.excedr.com/blog/what-is-flow-cytometry-how-do-flow-cytometers-work How to Break Into Biotech BD as a PhD Student: https://www.excedr.com/blog/how-to-break-into-biotech-bd-as-a-phd-student How to Spin Out of Academia & Into a Startup: https://www.excedr.com/resources/how-to-spin-out-of-academia-and-into-a-startup Why Some Biotech Startups Struggle to Scale: https://www.excedr.com/resources/why-some-biotech-startups-struggle-to-scale Gattaca (1997): https://www.imdb.com/title/tt0119177/ Hidden Talents of Natural Killers: NK Cells in Innate and Adaptive Immunity (EMBO Reports): https://pmc.ncbi.nlm.nih.gov/articles/PMC2759738/ How Experts Practice Better Than the Rest — Deliberate Practice & the 10,000 Hour Rule: https://jamesclear.com/deliberate-practice-strategy 


    Companies, Universities, & People Mentioned:

    Companies & Universities:Thielsen Capital: https://www.thielsencapital.com FlowJo: https://www.flowjo.com BD Life Sciences: https://www.bd.com Thermo Fisher Scientific: https://www.thermofisher.com Red Bull: https://www.redbull.com/us-en Clemson University: https://www.clemson.edu University of Virginia: https://www.virginia.edu MIT Sloan School of Management: https://mitsloan.mit.edu 
    People:Michael Brown, Ph.D. (Professor of Medicine – Nephrology, UVA; Principal Investigator, Brown Lab): https://med.virginia.edu/faculty/faculty-listing/mgb4n/

    Timestamps:00:00 Intro02:28 Growing Up at the Intersection of Business and Science07:52 The Science Obsession: Chemistry Textbooks and Secret Knowledge10:13 Biochemistry at Clemson: Earning the Hard Course16:09 Becoming a Red Bull Student Brand Manager on Campus18:31 Care Before You Share: Selling to Engineers at Midnight24:46 Leaving Red Bull Behind: The Pull Back to the Lab31:16 Michael Brown's Lab at UVA: NK Cells and Lab Culture39:12 Falling in Love with Flow Cytometry and Crying Over FlowJo41:31 The PhD as an Ultra-Marathon: Finding Your Sustainable Pace48:45 The Lab as a Startup: Skin in the Game Science49:55 Outro

    The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.
    51 min
  • 🧬 AI & Capital Efficiency: Building a Lab-Free Biotech | Caitlyn Krebs (Part 4/4)
    🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.
    As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.

    "Trust yourself, trust your instincts, and also the relationships and partnerships that you build along the way — because at the end of the day, it's all about the people."

    In this episode of The Biotech Startups Podcast, we dive into how Nalu Bio CEO and co-founder Caitlyn Krebs is harnessing AI and the largely untapped endocannabinoid system (ECS) to build the first nonhormonal therapeutic for the two hundred million women living with endometriosis, while running an ultra-lean company with no lab, no university royalties, and a fully outsourced CRO/CMO model. She explains why CB1 and CB2 GPCRs are among pharma’s most druggable targets, how Nalu’s platform has sped drug development by 5x while doubling phase one success rates, and why the ECS may be medicine’s most overlooked frontier amid a women’s health landscape still dominated by opioids, chemical menopause, and invasive surgery.


    Key topics covered:

    • Capital Efficiency in Biotech: Why your next value inflection point matters more than a two-year runway
    • Founding Nalu Bio: How two VC cofounders built a lean, lab-free CRO/CMO-driven company from day one
    • The Endocannabinoid System: Why CB1 and CB2 GPCRs are among pharma's most druggable — and most ignored — targets
    • Endometriosis & the Unmet Need: The brutal reality of treating 200 million women with opioids, hormones, and surgery
    • AI-Driven Drug Discovery: 5x faster development, 2x better phase one success rates — before a molecule is ever made
    • Pipeline vs. Platform: Feeding the engine while bringing your drug assets to market
    • Global CRO Strategy: Picking the best partners worldwide for speed, quality, and cost efficiency
    • IP Strategy: Why Nalu guards its platform as a trade secret — not a patent
    • Women's Health as an Investment: $100 billion in exits over 25 years — women are not a niche market

    If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.


    Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ 
    Find our guest, Caitlyn Krebs at these links: LinkedIn: https://www.linkedin.com/in/caitlynkrebs/Website: https://www.nalubio.com/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/jonchee
    Learn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com
    Intro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin 

    Resources & Articles:The Endocannabinoid System: Essential and Mysterious https://www.health.harvard.edu/blog/the-endocannabinoid-system-essential-and-mysterious-202108112569Review of the Endocannabinoid System – NIH/PMC https://pmc.ncbi.nlm.nih.gov/articles/PMC7855189/CB1 & CB2 Receptor Pharmacology – NIH/PMChttps://pmc.ncbi.nlm.nih.gov/articles/PMC5812699/Endometriosis Treatment Options – Franciscan Healthhttps://www.franciscanhealth.org/community/blog/endometriosis-treatment-optionsThe Four Stages of Endometriosis – CCRM Fertility https://www.ccrmivf.com/blog/four-stages-of-endometriosis/The Role of AI in Biotech and AI-Driven Drug Discovery https://cbdw.ai/the-role-of-ai-in-biotech-and-ai-driven-drug-discovery/AI in Pharma and Biotech: R&D Case Studies & Trends https://intuitionlabs.ai/articles/ai-pharma-biotech-drug-discovery-case-studies

    Companies, Universities, & People mentioned:BlueStar Genomics: https://spirolab.com/project/bluestar-genomics/Rock Health: https://rockhealth.comNVIDIA Inception Program: https://www.nvidia.com/en-us/startups/Silicon Valley Bank (SVB): https://www.svb.comFounders Fund: https://foundersfund.com
    Phyllis Whiteley: https://www.linkedin.com/in/phyllis-whiteley-phd-b5821317Ken Mackie: https://www.linkedin.com/in/ken-mackie-2602057


    Timestamps: 00:00 Intro02:24 Capital Efficiency and Getting to the Next Inflection Point05:39 The Origin of Nalu Bio and the Endocannabinoid System07:32 Co-founding Nalu Bio with Phyllis and Randall08:07 Early Days: Building the Team and Technology10:08 Endometriosis: The Market, the Problem, and the Patients17:05 Balancing Pipeline vs. Platform Development18:57 Business Model: Licensing Assets at Phase Two20:53 Company Structure: CROs, CMOs, and Capital Efficiency22:37 Choosing CRO Partners by Region and Size25:38 From Platform-Building to the Clinic: Nalu Bio's Evolution27:14 IP Strategy: Patents vs. Trade Secrets31:10 Looking Ahead: Phase Two, Pharma Partnerships, and AI34:47 Shout-Outs and Closing Advice37:55 Outro

    The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.
    42 min
  • 🧬 Small Community, Long Journey: The Power of Relationships in Biotech | Caitlyn Krebs (Part 3/4)
    🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.
    As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.
    "You just don't know where these people will play a role in your life, but also, you don't know who they know. Business is a small community, and the journey's long."

    In this episode of The Biotech Startups Podcast, Caitlyn Krebs traces her path from a gut-punch company shutdown on maternity leave — which unexpectedly forged a key cofounder relationship — through the digital health boom at Rock Health, to her role as COO at Neurotrack, where an eye-tracking Alzheimer's test launched to 137 countries within days and led to selling cognitive risk scores to Japanese life insurers as the only woman in the room. She closes out her pre-Nalu journey at BlueStar Genomics, where hard lessons in capital discipline and the dangers of scope creep shaped the focused, founder-ready mindset she brings to building Nalu Bio today.

    Key Topics Covered:

    • Turning Adversity into Opportunity: How a shutdown on maternity leave sparked an unexpected cofounder relationship
    • VC Mindset at Rock Health: What VCs really look for — team, traction, market size, and the D2C trap
    • Neurotrack & Cognitive Health: Going global in days with an eye-tracking Alzheimer's test and selling risk scores to Japanese life insurers
    • Cross-Cultural Enterprise Sales: Holding her ground in high-stakes negotiations in Japan as the only woman in the room
    • Capital Discipline & Focus: Why staying in your lane — and resisting the urge to do it all — is a startup superpower


    If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.
    Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ 
    Find our guest, Caitlyn Krebs at these links: LinkedIn: https://www.linkedin.com/in/caitlynkrebs/Website: https://www.nalubio.com/
     Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/jonchee
    Learn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com
    Intro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin 

    Resources & Articles:Eye Tracking as a Tool for Alzheimer's Detection https://www.tobii.com/resource-center/learn-articles/4-methods-to-assess-alzheimers-with-eye-trackingIs D2C in HealthTech a Viable Business Model? https://healthtechd2c.substack.com/p/is-d2c-in-healthtech-a-viable-businessHealthTech Business Models Explained: The Case for B2B2C https://htdhealth.com/insights/healthtech-business-models-explained-benefits-of-b2b2c/A Guide to the Venture Capitalist Decision-Making Process https://www.excedr.com/resources/guide-to-the-venture-capitalist-decision-making-process VC Funding 101 https://www.excedr.com/blog/vc-funding-101 

    Companies, Universities, & People mentioned:Rock Health: https://rockhealth.comNeurotrack: https://www.neurotrack.comGRAIL: https://grail.com

    Timestamps: 00:00 Intro02:20 Lessons from Tethys: Reimbursement Risk and Commercialization Challenges04:29 Shutting Down on Maternity Leave and Turning a Wind‑Down into a Cofounder Relationship08:28 Long‑Game Relationship Building and Why You Don’t Burn Bridges10:26 Selling “Your Baby”: Finding a New Home for Tethys’ Technology12:28 Entering the Digital Health Boom at Rock Health14:38 How VCs Evaluate Startups: Team, Traction, Market, and Business Model17:02 The D2C Pendulum and Emerging Women’s Health Channels19:40 Joining Neurotrack: Eye‑Tracking to Detect Early Cognitive Decline22:31 Launching a Web‑Based Alzheimer’s Risk Test in 137 Countries and D2C Lessons24:09 Selling Cognitive Risk Scores to Japanese Life Insurers as a Female Executive34:18 Epigenetics and Early Cancer Detection at BlueStar Genomics, Focus, and Capital Discipline37:05 Outro

    The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.
    39 min
  • 🧬 The Hidden Skills Scientists Need to Build Real Companies | Caitlyn Krebs (Part 2/4)
    🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.
    As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.

    "If you are capable of acquiring knowledge, of applying the knowledge, and you like it, you can succeed. It doesn't matter what it is."

    In this episode of The Biotech Startups Podcast, Caitlyn Krebs
    , co-founder and CEO of Nalu Bio, traces her path from building the Bay Area's biotech ecosystem to operating at the cutting edge of science and business. She shares how launching BayBioNEST taught her what it really takes—beyond great science—to build durable companies, before diving into her time at Entelos, where she helped pioneer virtual patients and digital twins nearly twenty years before AI became a buzzword, and unpacks what BD actually means in biotech, from navigating black-box skepticism to running "bake-off" pilots that let the data speak for itself. The conversation then shifts to Tethys Bioscience, where Caitlyn helped bring a prediabetes diagnostic to market—winning over physicians, employers, and major payers like Aetna, United, and Cigna—only to watch a single Medicare/CMS misstep shutter a well-funded company, and what every founder can learn from that hard-won experience.


    Key topics covered:
    • Building BayBioNEST: Launching a scrappy pre-accelerator to give academic scientists the business skills they never learned at the bench.
    • Pioneering virtual patients: Building biological models and digital twins decades before AI hype to reshape drug development.
    • What BD really is in biotech: Structuring deals, overcoming skepticism, and using “bake-off” pilots so the science sells itself.
    • Selling prediabetes diagnostics: Winning physicians and employers over to a predictive test for an under-recognized disease.
    • The power and peril of reimbursement: How one Medicare/CMS call can wipe out strong data, major payers, and massive funding.

    If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.

    Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ 
    Find our guest, Caitlyn Krebs at these links: LinkedIn: https://www.linkedin.com/in/caitlynkrebs/Website: https://www.nalubio.com/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/jonchee
    Learn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com
    Intro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin 

    Resources & Articles:What Is Business Development in Biotech & Pharma? https://chivanta.com/what-is-business-development-biotech-pharma/What Is Quantitative Systems Pharmacology (QSP) Modeling? https://www.news-medical.net/life-sciences/What-is-Quantitative-Systems-Pharmacology-(QSP)-Modeling.aspxHow CMS/Medicare Reimbursement Works for Diagnostic Lab Tests https://www.fiercebiotech.com/medical-devices/diagnostics-companies-strike-back-at-cms-lab-test-ruleTop Biotech Accelerators and Incubators in 2026 https://www.peony.ink/blog/top-10-biotech-startup-acceleratorsQuantitative Systems Pharmacology (QSP) Modeling – University of Florida Course Overviewhttps://onlinepc.pharmacy.ufl.edu/programs/courses/quantitative-systems-pharmacology-qsp-modeling/US Medicare Sets Reimbursement Price for PromarkerD — A Case Study in Diagnostic Reimbursementhttps://biotechdispatch.com.au/news/us-medicare-sets-reimbursement-price-for-promarkerd-paving-way-for-major-commercial-rollout

    Companies, Universities, & People mentioned:Entelos: https://mtec-sc.org/life-sciences/entelosPfizer: https://www.pfizer.comAetna: https://www.aetna.comUnitedHealthcare: https://www.uhc.comCigna: https://www.cigna.comGeorge Rathmann: https://en.wikipedia.org/wiki/George_Rathmann
    Timestamps: 00:00 Intro02:16 Fundraising and Running BayBio's Membership Organization02:30 Launching BayBioNEST: A Pre-Accelerator for Academic Scientists06:55 The Rise of Biotech Incubators and Early Ecosystem Building09:50 Transitioning from Ecosystem Builder to Operator10:36 Entelos: Pioneering Virtual Patients and Digital Twins11:52 What Business Development (BD) Really Means in Biotech15:44 The "Bake-Off" Strategy: Letting the Models Speak for Themselves18:51 Moving On: The Pull Toward a Product Company19:36 Joining Tethys Bioscience and Selling Prediabetes Diagnostics21:52 Mapping the Healthcare Ecosystem: Patients, Physicians, and Employers22:52 The Medicare/CMS Misstep That Shut Down a $200M Company23:32 Outro

    The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.
    25 min
  • 🧬Unconventional Career Moves in Biotech: Finding a Path to Leadership | Caitlyn Krebs (Part 1/4)
    🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.
    As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.


    “There are many different ways to get into leadership roles in biotech — there is not one door.”

    In this episode of The Biotech Startups Podcast, Caitlyn Krebs, co-founder and CEO of Nalu Bio, traces her journey from tagging endangered sea turtles on the Big Island of Hawaii to leading an AI-powered company designing novel cannabinoid-inspired small molecules for pain, inflammation, endometriosis, and metabolic disease. She reflects on being humbled at Brown University, where she fell in love with data analysis while studying leptin and early obesity science, then recounts jumping into the Bay Area’s dot-com boom as the third employee at a startup before, at just 27, taking the helm of BayBio and managing a 26-person board of biotech leaders—along the way crossing paths with a 20-year-old Stanford dropout named Elizabeth Holmes.

    Key topics covered:
    • Growing Up in Hawaii: Tagging endangered sea turtles and discovering a lifelong passion for science
    • Brown University & Early Humility: Getting humbled at an Ivy, doubling down on orgo, and falling in love with data
    • From .com to Biotech: Jumping into a dot-com startup and learning entrepreneurship the hard way
    • Running BayBio at 27: Leading a biotech trade group and a 26-person board long before most peers managed a team
    • Board Management Lessons: Keeping board meetings focused, aligning motivations, and leveling up with modern tools like Zeck


    If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.

    Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ 
    Find our guest, Caitlyn Krebs at these links: LinkedIn: https://www.linkedin.com/in/caitlynkrebs/Website: https://www.nalubio.com/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/jonchee
    Learn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com
    Intro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin 

    Resources & Articles:Hawaiian Green Sea Turtle Conservation: https://www.fisheries.noaa.gov/species/green-turtleThe Endocannabinoid System Explained: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576607/Endometriosis: A Chronically Underserved Condition: https://www.who.int/news-room/fact-sheets/detail/endometriosisOrganic chemistry explained: https://www.britannica.com/science/organic-chemistryThe Dot-Com Boom and Its Legacy on Silicon Valley: https://www.investopedia.com/terms/d/dotcom-bubble.aspAI-Powered Drug Discovery in Biotech: https://www.nature.com/articles/s41587-023-01693-z​Companies, Universities, & People mentioned:Brown University: https://www.brown.edu/Zeck: https://www.zeck.app/
    John C. Martin: https://www.gilead.com/news/news-details/2021/gilead-sciences-comments-on-the-passing-of-john-c-martin-phdElizabeth Holmes: https://www.linkedin.com/in/elizabeth-holmes-bb7326238Edward Norton: https://fortune.com/2024/04/29/zeck-cofounded-by-edward-norton-raises-7-million-board-meetings-software/

    Timestamps: 00:00 Intro05:02 Growing Up on the Big Island of Hawaii06:37 Tagging Endangered Hawaiian Green Sea Turtles08:01 Choosing Brown University Over the West Coast10:26 Culture Shock: From Hawaii to Providence14:01 Undergraduate Lab Experience and Falling in Love with Data17:09 Moving to San Francisco During the Dot-Com Boom18:40 Joining Zedo as a Third Employee and Learning Entrepreneurship21:46 Managing Engineers for the First Time24:14 Transitioning Into the Biotech World via BayBio26:18 Becoming President of BayBio at 2728:38 Key Lessons and Pitfalls in Board Management31:59 Using Zeck to Streamline Board Meetings33:52 Outro

    The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.
    36 min
  • 🧬 The Founder Identity Trap: Navigating the Hidden Mental Cost of Leadership | Nicole Paulk (Part 4/4)
    🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.
    As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.

    "Not wrapping your entire self-worth up in whether or not your company works — that is a learned skill."

    In this episode of The Biotech Startups Podcast, Siren Biotechnology CEO & Founder, Nicole Paulk unpacks why being a first-time female technical academic founder CEO — "the worst possible thing you could be" — was actually the best CEO training imaginable. She breaks down how her scrappy academic mindset stretched a $6M seed round across three and a half years, why going all-in on unglamorous CMC optimization was Siren Biotechnology's most important early decision, and why capital efficiency is a company-defining mindset, not just a financial strategy. Nicole also opens up about the loneliness of the founder CEO role, the toxic culture of "competitive complaining" at industry meetups, and the profound weight of Siren's recent FDA IND clearance — and what it means to be on the verge of dosing the very first brain cancer patient at UCSF.


    Key topics covered:
    • Academic Founders as CEOs: Why scrappy scientists make the best capital-efficient startup builders
    • Stretching Capital: How Siren's $6M seed lasted three and a half years — and why a long runway forces better science
    • CMC as a Competitive Advantage: Why early investment in unglamorous manufacturing optimization can make or break your company
    • Founder Mental Health & Loneliness: The risks of tying your identity to your company and why "competitive complaining" is toxic for the industry
    • Siren's FDA IND Milestone: The profound weight of becoming clinical-stage and nearing the first brain cancer patient dose

    If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.

    Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ 
    Find our guest, Nicole Paulk at these links: LinkedIn: https://www.linkedin.com/in/nicolepaulk/Website: https://sirenbiotechnology.com/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/jonchee
    Learn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com
    Intro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin 
    Resources & Articles:Lean Startup Principles for Founders:https://hbr.org/2013/05/why-the-lean-start-up-changes-everythingIND (Investigational New Drug) Application Basics:https://www.fda.gov/drugs/types-applications/investigational-new-drug-ind-applicationFounder Burnout and Mental Health in Startups:https://www.ycombinator.com/library/6i-how-to-deal-with-founder-depression
    Companies, Universities, & People mentioned:Silicon Valley Bank (SVB): https://www.svb.comFounders Fund: https://foundersfund.com
    Timestamps: 00:00 Intro02:24 Why Being a First-Time Female Academic Founder CEO Is the Best CEO Training09:59 Making a Small Seed Round Last: How $6M Stretched Three and a Half Years11:00 The Case for Capital Efficiency and Thoughtful Science16:23 The Problem with Founder "Bitch-Fest" Meetups19:16 A Better Model: Solution-Focused Founder Gatherings22:11 The Loneliness of the Founder CEO and Mental Health23:54 Knowing When to Dial It Up and Dial It Back26:23 Building Community Without Competitive Complaining29:54 Advice to Her 21-Year-Old Self: Follow the Weird Little Sprites33:04 Shoutouts and Gratitude34:20 Siren's FDA IND Clearance and the First Patient on the Horizon38:40 Outro

    The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.
    43 min
  • 🧬 Let the Science Lead: Building Successful Biotechnology | Nicole Paulk (Part 3/4)
    🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.
    As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.

    "Just that ability to have pure, unfettered, unbothered, and undistracted time to just really go hard and let the science take you where it will. I think that could be transformative."

    In this episode of The Biotech Startups Podcast, Nicole Paulk recounts her unlikely evolution from frustrated academic to biotech founder — driven by years of watching gene therapy companies wastefully rebuild the same tech stack from scratch, a pandemic lockout that barred her from her own UCSF lab, and a sneaky incorporation scheme that was less grand vision, more workaround to get back to the bench. She shares how a frantic three-day cancer grant, a fever-dreamed logo, and a Best Startup win at UCSF's entrepreneurship course led to a $6,000,000 Founders Fund seed with no board attached, and how Siren's unconventional early bet on unglamorous CMC manufacturing optimization — paired with years of deliberate stealth — became the company's most powerful and defensible competitive advantage.

    Key Topics Covered:

    • The Gene Therapy Tech Stack Problem: Every AAV company rebuilding the same wheel — and the bold idea that sparked Siren
    • Founding Siren: How a pandemic lockout, a brain tumor grant, and a sneaky incorporation gave birth to a biotech company
    • Founders Fund & the Boardless Seed: $6M, no board, no permission needed — and why Nicole thinks more startups should start this way
    • The Unglamorous CMC Bet: Going all-in on manufacturing optimization from day one — boring on purpose, defensible forever
    • Stealth, IP, and Operating in an Accelerating World: Why the old rules on patents and publishing are dead — and what founders should do instead

    If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.

    Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ 
    Find our guest, Nicole Paulk at these links: LinkedIn: https://www.linkedin.com/in/nicolepaulk/Website: https://sirenbiotechnology.com/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/jonchee
    Learn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com
    Intro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin 
    Resources & Articles:AAV Gene Therapy Overview: https://pmc.ncbi.nlm.nih.gov/articles/PMC5548848/AAV as a Clinical Gene Therapy Vector: https://www.nature.com/articles/s41392-024-01780-wWhat Is AAV Gene Therapy?: https://www.creative-diagnostics.com/what-is-aav-gene-therapy.htmViral Vectors in Gene & Cell Therapy (AAV included): https://patienteducation.asgct.org/understanding-cell-gene-therapy/viral-vectorsThe Age of AAV in Gene Therapy: https://wyss.harvard.edu/news/gene-therapy-the-age-of-aav/CMC Requirements for Gene and Cell Therapy INDs: https://pacificbiolabs.com/gene-therapy-cmc-requirements/

    Companies, Universities, & People mentioned:Founders Fund: https://foundersfund.comBayer (Collaborator incubator context): https://www.bayer.comNIH (National Institutes of Health): https://www.nih.gov/
    Jennifer Doudna: https://www.linkedin.com/in/jennifer-doudna-79b63527/ Scott Nolan: https://www.linkedin.com/in/scottpnolan/ 
    Timestamps: 00:00 Intro02:19 Frustrations with Gene Therapy's "Reinvent the Wheel" Problem03:41 The Vision for a Universal AAV Gene Therapy07:00 Ballooning Costs and the Perverse Incentives of the Gene Therapy Market09:31 The UCSF Brain Tumor Gift and a Frantic Three-Day Two-Pager11:55 COVID Shuts Down the Lab: Industry vs. Academia as Essential Workers12:27 Incorporating Siren as a Sneaky Way to Get Back to Work14:16 UCSF Entrepreneurship Course, Winning Best Startup, and Landing Founders Fund16:02 The Freedom of $6M with No Board: Moving Fast and Doing Better Science24:15 Going All-In on CMC: The Unglamorous but Smart Early Move28:41 Staying Stealth: When to Come Out and When to Stay Hidden34:49 The Future of Biotech: Small, Nimble, and Focused Teams37:33 Outro

    The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.
    39 min
  • 🧬 The Dark Side of Postdoc Culture Nobody Talks About | Nicole Paulk (Part 2/4)
    🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.
    As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.

    "Your life doesn't have to be scripted. Really cool things can happen in an unscripted life if you're open to opportunity and willing to take risks and do cool stuff."

    In this episode of The Biotech Startups Podcast, we continue founder, CEO, and president of Siren Biotechnology, Nicole Paulk's journey from small-town farm kid to pioneering gene therapy scientist. Nicole recounts how a Craigslist ad landed her in the lab of one of the most celebrated stem cell scientists in the country, Markus Grompe — blissfully unaware of his fame, she spent months calling him "Marky Mark," planting whoopee cushions under his chair, and filling donut holes with Sriracha, only to discover he was the stem cell adviser to the President of the United States. She reflects on her PhD years as the "golden, pure, best days" of her scientific life, then contrasts that with the culture shock of Stanford's relentless postdoc hustle, a world of constant CV-optimization and pressure to pursue academia at all costs. Nicole shares how landing a coveted K01 grant gave her the credentials to walk through any university door she wanted, eventually bringing her to UCSF just nine months before COVID would turn everything upside down.

    Key topics covered:
    • The Craigslist Lab Discovery: How one unscripted career move led Nicole to one of the most celebrated stem cell labs in the country
    • Working With Markus Grompe: Pranks, camaraderie, and world-class science in a lab that had culture before culture was a thing
    • PhD vs. Postdoc: Free-spirited curiosity versus the relentless CV-optimization grind of Stanford
    • Academic Pressure & Identity: Why postdoc culture pushes trainees toward academia at all costs — and why that needs to change
    • From Stanford to UCSF: A K01 grant, a bold leap to UCSF, and then COVID hits


    If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.

    Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ 
    Find our guest, Nicole Paulk at these links: LinkedIn: https://www.linkedin.com/in/nicolepaulk/Website: https://sirenbiotechnology.com/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/jonchee
    Learn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com
    Intro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin 
    Resources & Articles:AAV (Adeno-Associated Virus) Gene Therapy: https://en.wikipedia.org/wiki/Adeno-associated_virusStem Cell Research in the 2000s: https://www.ebsco.com/research-starters/history/stem-cell-research-2000sThe Oregon Stem Cell Center at OHSU: https://www.ohsu.edu/stem-cell-centerNIH K01 Mentored Research Scientist Development Award: https://grants.nih.gov/grants/guide/pa-files/PA-24-176.htmlPhD vs. Postdoc: Mental Health & Pressure in Academia: https://pmc.ncbi.nlm.nih.gov/articles/PMC11693439/COVID-19's Impact on Academic Research Labs: https://www.nature.com/articles/d41586-021-00663-2
    Companies, Universities, & People mentioned:OHSU (Oregon Health & Science University): https://www.ohsu.eduStanford University: https://www.stanford.eduUCSF (University of California, San Francisco): https://www.ucsf.edu
    Markus Grompe: https://www.linkedin.com/in/markus-grompe-m-d-66211273/ Mark A. Kay: https://www.linkedin.com/in/mark-kay-md-phd-41a7313/ 

    Timestamps: 00:00 Intro02:21 Finding a Lab Job on Craigslist and Landing at OHSU05:31 Discovering Markus Grompe Was Famous (All Along)07:01 Whoopee Cushions, Sriracha Donuts, and "Marky Mark"10:01 Joining Grompe's Lab and the Golden Days of the PhD13:06 Life Advice: You Don't Have to Script Your Journey15:46 Transitioning from PhD to Postdoc at Stanford19:11 Stanford's Hustle Culture: Loved It and Hated It21:21 The Pressure of the Postdoc: Finding a Real Plan22:31 Academia's "Professor or Failure" Mentality24:26 Earning the K01 Grant and Moving to UCSF25:51 COVID Shuts Down the Lab — and Sparks the Founding of Siren26:12 Outro

    The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.
    28 min
  • 🧬 2 Identity Crises, 1 Mission: From Broken Shoulder to Biotech Career | Nicole Paulk (Part 1/4)
    🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.
    As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.

    “No one’s going to come and save you. You have to save yourself.”

    In this episode of The Biotech Startups Podcast, we sit down with Nicole Paulk
    , founder, CEO, and president of SIREN Biotechnology, a company pioneering universal AAV immunogene therapy to fight solid tumor cancers. Nicole takes us back to her roots — a scrappy, off-the-grid upbringing in the Pacific Northwest where a lumberjack dad raised her like a son and sports were everything, until recurring shoulder injuries ended her collegiate volleyball career at 18 and triggered her first identity crisis. She walks us through the hustle that followed; swim lessons, kickboxing classes, deli shifts, and crabbing in Puget Sound just to survive, and how she stumbled into science not out of passion, but out of a need for a paycheck at a small ag school. A summer treating patients in Kenya and Tanzania convinced her that clinical medicine wasn't her path, and one offhand comment from her chemistry professor set the entire trajectory of her scientific career in motion.
    Key topics covered:

    • Farm Kid to Founder: Growing up off-the-grid in the Pacific Northwest forged the grit and competitiveness Nicole brings to every aspect of her life and leadership
    • Identity Crisis at 18: How recurring shoulder injuries ended her collegiate volleyball career and forced a complete rethinking of who she was
    • Hustling Through College: Swim lessons, kickboxing classes, deli shifts, and crabbing just to make rent and stay enrolled
    • Summer in Africa: Three and a half months treating patients in Kenya and Tanzania revealed she wasn't cut out for clinical medicine
    • A Career-Defining Pivot: One offhand suggestion from her chemistry professor, Dr. Anya Johansen, redirected Nicole from med school to a PhD in virology

    If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.

    Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ 
    Find our guest, Nicole Paulk at these links: LinkedIn: https://www.linkedin.com/in/nicolepaulk/Website: https://sirenbiotechnology.com/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/jonchee
    Learn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com
    Intro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin 
    Resources & Articles:What Is AAV Gene Therapy?: https://www.askbio.com/aav-gene-therapy/Ebola & Marburg Hemorrhagic Fever Viruses: https://www.cfsph.iastate.edu/Factsheets/pdfs/viral_hemorrhagic_fever_filovirus.pdfAAV Capsids That Evade Neutralizing Antibodies: https://www.cgtlive.com/view/maura-aav-capsids-evade-neutralizing-antibodiesAAV as a Vector for Gene Therapy (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC5548848/Volunteer Medical Work in Africa: https://idi.mak.ac.ug/opportunities/main/volunteer/​Companies, Universities, & People mentioned:Western Washington University: https://www.wwu.eduCentral Washington University: https://www.cwu.eduUniversity of Washington: https://www.washington.eduOregon Health & Science University (OHSU): https://www.ohsu.eduUCSF Department of Biochemistry & Biophysics: https://biophysics.ucsf.eduStanford Division of Human Gene Therapy: https://med.stanford.edu/genetherapy.htmlBill & Melinda Gates Foundation: https://www.gatesfoundation.org
    Timestamps: 00:00 Intro03:50 Nicole's Hippie Farm Kid Upbringing in the Pacific Northwest05:36 Sports-Centered Childhood and Lessons in Competing Solo vs. as a Team08:19 Small Town Grit: Community, Self-Reliance, and the Value of Hard Work14:00 Choosing a College Based on What She Could Afford15:49 Volleyball Career Ends at 18: Shoulder Injuries and an Identity Crisis16:56 Surviving on Odd Jobs: Swim Lessons, Kickboxing, and Deli Shifts19:29 Crabbing in Puget Sound and Transferring to an Ag School20:45 Falling Into Science for a Paycheck, Not Passion24:36 Dream of Becoming an Infectious Disease Doctor26:06 The Letter-Writing Campaign to Fund a Summer in Africa29:10 Kenya and Tanzania Change Everything: Realizing Medicine Isn't the Path31:06 A Chemistry Professor's Offhand Comment Redirects Her Toward a PhD32:13 Outro

    The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.
    34 min
  • 🧬 The Competitive Threat Reshaping US Drug Discovery Strategy | Richard Yu (Part 4/4)
    🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.
    As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.

    "The only way through is through. You have to actually go through some of this stuff."

    In this episode of The Biotech Startups Podcast, co-founder and CEO of Abalone Bio, Richard Yu reflects on how processing grief after losing his co-founder, Gustavo Pesce, brought clarity and renewed focus — stripping away the inessential and driving him forward at Abalone Bio. He unpacks the strategic thinking behind the pipeline, from developing CB2 agonist antibodies that reverse fibrosis and reduce neuropathy, to deciding which programs to partner versus develop internally based on value inflection points. Richard also reflects on hitting his 400th VC rejection, why the West Coast's frontier mentality fuels entrepreneurial resilience, how the rise of China's biotech ecosystem is pushing US startups toward novel targets as a competitive moat, and how AI has transformed once-impossible problems — from protein folding to natural language — into solved challenges that are fundamentally reshaping drug discovery.

    Key topics covered:

    • Processing Grief & Finding Clarity: How Gustavo's passing reframed Richard's perspective on mortality, gratitude, and what truly matters
    • Pipeline Strategy: Using value inflection points to decide what to partner versus build internally
    • VC Resilience: 400 rejections and why the West Coast frontier mentality keeps founders going
    • US vs. China Biotech Landscape: How China's biotech rise is forcing US startups to bet on novel targets
    • AI & the Future of Drug Discovery: How AI turned yesterday's impossible problems into today's solved ones, and what's next for Abalone Bio

    If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.
    Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ 
    Find our guest, Richard Yu at these links: LinkedIn: https://www.linkedin.com/in/richard-c-yu/Website: https://www.abalonebio.com/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/jonchee
    Learn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.com
    Intro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin 
    Resources & Articles:Range: How Generalists Triumph in a Specialized World https://www.goodreads.com/book/show/52390465-rangeWaking Up App (Sam Harris): https://www.wakingup.comInternal Family Systems (IFS): https://www.psychologytoday.com/us/therapy-types/internal-family-systems-therapyEnneagram of Personality: https://en.wikipedia.org/wiki/Enneagram_of_PersonalityGPCR Drug Discovery & Novel Targets: https://www.nature.com/articles/nrd.2017.178The Pharma Patent Cliff (2026–2030): https://www.drugpatentwatch.com/blog/the-data-driven-guide-to-winning-the-2026-patent-cliff/​Companies, Universities, & People mentioned:Y Combinator: https://www.ycombinator.com/QB3: https://qb3.org/
    Gustavo Pesce - in memoriam https://www.abalonebio.com/about​David Epstein https://www.linkedin.com/in/david-epstein-5a37ba25Sam Harris https://www.wakingup.com/about​Lindsay Briner https://www.linkedin.com/in/lindsaybrinerJay Wilson https://www.linkedin.com/in/jay-wilson-202224377
    Timestamps: 00:00 Intro02:22 Resilience, Perseverance, and the "I Will Not Quit" Mentality05:19 Pipeline Strategy: When to Partner vs. Develop Internally07:17 Navigating the Rise of China in Biotech and the Case for Novel Targets11:35 Abalone Bio's One-to-Five Year Vision16:53 The Entrepreneurial "Sickness": Why Founders Keep Starting Companies17:43 West Coast Frontier Mentality vs. East Coast Agricultural Mindset20:47 Authenticity in Fundraising: Seeking vs. Filtering23:35 The Value of Experience in a Youth-Obsessed Silicon Valley Culture26:28 Shout-Outs: Family, Co-Founder Gustavo Pesce, and Key Mentors30:45 Portfolio Construction Thinking in Life Sciences32:37 The Power of Breadth: How Diverse Experiences Drive Success34:32 Outro
    The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.
    38 min

About The Biotech Startups Podcast

From the publisher's feed

The Biotech Startups Podcast by Excedr features weekly conversations with founders, scientists, and investors driving biotech innovation. Host Jon Chee dives into the challenges of building biotech…

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