The Charlotte Greenwood Show was a radio situation comedy in the United States. It was broadcast on ABC June 13 - September 5, 1944, and on NBC October 15, 1944 - January 6, 1946.

The program began as a summer replacement for The Bob Hope Show. Newspaper columnist Hedda Hopper reported, "The interesting thing is that she [Charlotte Greenwood] got the job on a couple of scripts written by her husband, Martin Broones, who's never before written for radio.

The 1944 version of the show had Greenwood in the role of a cub reporter who worked for a small newspaper while she harbored dreams of becoming a Hollywood star. When the program resurfaced in 1945, Greenwood's character had the responsibility of raising three children, teenagers Jack and Barbara and little Robert after her good friend died, making her executor of the estate. The setting was the mythical town of Lakeview. An old time radio reference commented that Greenwood's character "managed to be single, moral, and peppy.