On this episode of The Climate Biotech Podcast, we're sitting down with the legendary George Church. A pioneer in genomics and synthetic biology, George is known for his innovative visions for future tech — and for developing the foundational tools to get us there. 

This conversation spans a gamut of creative ideas including observing planetary metabolomes with satellites, cleaning up supply chains via total recycling, advancing inorganic synthetic biology using multiplex DNA libraries, and harnessing developmental biology to surpass current 3-D printing capabilities.

Tune in to hear George's unique perspective on how biotechnology can provide infinitely scalable and atomically precise solutions to our planet's most pressing issues.

(00:00) Introduction to the Climate Biotech Podcast
(02:26) Meet George Church: Early Life and Career
(04:23) The State of Synthetic Biology and Bioengineering
(06:13) Future -omes and Planetary Scale Biotech
(08:47) Writing Genomes and Climate Biotech
(10:22) Infinitely Scalable and Atomically Precise Biology
(20:38) Inorganic Synthetic Biology and New Frontiers
(23:26) Paul Reginato's Segment: Climate Relevant Problems
(36:13) Audience Q&A and Rapid Fire Questions
(41:17) Closing Remarks and Thank You

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How does a love for life and a deep passion for science fuel groundbreaking climate solutions? Join us as we spotlight Homeworld Founding Scientist Paul Reginato, who launched Homeworld Collective alongside Dan Goodwin to empower the climate biotech community.

Paul shares his journey, from starting as an aspiring young artist, to falling in love with biology as an undergraduate, to developing foundational in situ sequencing tech as a PhD researcher at MIT, to leading community roadmapping efforts for open problems in climate biotech. 

We explore how microbes can help in mitigating greenhouse gas emissions and how communicating open problems can empower innovation in a community.

(00:00) Introduction to the Climate Biotech Podcast
(00:43) Meet the Hosts: Dan Goodwin and Paul Reginato
(01:38) Paul Reginato's Journey: From Art to Biology
(02:45) The Intersection of Love and Science
(03:27) Founding Homeworld Collective
(07:32) The Grind of Scientific Research
(10:19) From PhD to Climate Biotech
(13:41) The Problem Statement Repository
(21:20) Connecting Funders with Science
(22:07) Exploring Climate Biotech Problems
(22:47) Biology and Mineral Interactions
(23:56) Innovations in Mining and Carbon Management
(26:54) Microbial Community Functions in Mineral Weathering
(28:25) Challenges in Carbon Capture
(30:40) Community-Centric Approach at Homeworld
(35:10) Rapid Fire Questions with Paul
(39:23) Advice for Aspiring Biologists
(40:49) Dreams for Homeworld Collective
(42:10) Conclusion and Contact Information

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How does a fear of scuba diving transform into a career involving ocean microbes? Braden Tierney, the co-founder and executive director of the Two Frontiers Project, shares his incredible journey from studying the human microbiome to pioneering climate biotechnology. With a dual degree in biology and economics from Duke University and a PhD from Harvard Medical School, Braden’s fascinating story is one of overcoming personal fears and merging diverse skills to create a unique niche in environmental microbiology. His enriching experiences, from internships at the Woods Hole Oceanographic Institution to postdoctoral work at Weill Cornell Medical College, underscore the importance of interdisciplinary collaboration in groundbreaking research.

Listen as Braden discusses the strides made by the Two Frontiers Project, a nonprofit exploring life’s diversity in extreme environments like oceans and space. Learn about their groundbreaking research on carbon sequestering cyanobacterium and coral technology, including the discovery of a novel strain, which thrives in high CO2 environments and may hold the key to effective carbon sequestration. This episode illuminates the challenges and triumphs of pioneering research, from early setbacks to successful collaborations that push the boundaries of science and sustainability. Braden's insights into the cultivation of a living microbial database and the development of coral health technologies reveal a roadmap to address planetary-scale challenges.

2FP's innovative strategies and tight-knit collaboration underscore the balance between academic research and practical deployment, aiming to solve medium-term climate problems. This episode serves as an educational and inspirational guide for anyone passionate about harnessing biotechnology for a sustainable future. 

(00:00) Introduction to the Climate Biotech Podcast
(00:36) Meet Braden Tierney: A Journey in Biology
(01:54) Early Fascination with Science
(03:27) Diving into Marine Biology
(05:18) The Importance of Side Projects
(05:57) Combining Skills for Unique Research
(07:53) Academic Journey and Mentorship
(13:26) Postdoctoral Adventures in Space Biology
(15:25) The Two Frontiers Project: Oceans and Space
(17:22) Challenges and Innovations in Microbial Research
(22:13) Challenges in Environmental Sampling
(25:58) The CO2 Story: Promising Isolates
(29:33) Coral Reef Health and Technology
(32:22) Future Expeditions and Climate Biotech
(35:54) Building Expertise for Climate Solutions
(37:52) Skills and Opportunities in Climate Biotech
(40:58) Conclusion and Call to Action

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How do upland trees contribute to the fight against climate change? Join us as we uncover the unexpected climate services of trees with Vince Gauci, an ecosystem scientist and biogeochemist at the University of Birmingham. 

In this episode of The Climate Biotech Podcast, we delve into the fascinating world of methane uptake by trees with ecosystem scientist and biogeochemist Vince Gauci. His groundbreaking research at the University of Birmingham offers new insights into the hidden roles that trees play in mitigating climate change. 

Throughout the episode, Vince's passion for ecosystem science and his dedication to addressing climate change are evident. His work underscores the importance of interdisciplinary approaches and integrating process-level research with large-scale modeling to provide a holistic understanding of ecosystem dynamics. This episode is packed with thought-provoking insights for researchers, policymakers, and environmental enthusiasts alike.

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Welcome to the Climate Biotech Podcast, where we explore critical challenges at the intersection of climate and biology.

Join us as we interview the most innovative voices in our sector, from scientists and entrepreneurs to policymakers and investors. Our guest today is Lisa Stein, American biologist who is a professor at the University of Alberta. Lisa shares her journey from growing up in the Rocky Mountains of Colorado to becoming a pioneering researcher in environmental science, discussing the intricacies of microbial processes and their impact on climate change. We delve into the complexities of greenhouse gases, including methane and nitrous oxide, and explore the potential of microbial and chemical solutions to mitigate their effects.

(00:00) Introduction to the Climate Biotech Podcast
(00:36) Meet Lisa Stein: A Leader in Methane and Nitrogen Cycles
(01:03) Lisa's Journey into Environmental Science
(01:34) Graduate Work and the Start of Microbial Research
(04:17) The Importance of Methane and Nitrous Oxide
(07:02) Challenges in Methane Removal
(08:16) Microbial and Chemical Solutions for Methane
(12:18) Understanding Redox Reactions
(15:21) Sources of Methane and Nitrous Oxide
(19:04) Linking Methane and Nitrous Oxide
(22:06) Soil Microbes and Greenhouse Gas Emissions
(24:08) The Role of Metals in Microbial Metabolism
(27:05) Ecological Interactions and Greenhouse Gas Mitigation
(31:15) Technological Approaches to Methane and Nitrous Oxide Reduction
(38:11) Audience Q&A: Methane, Nitrous Oxide, and Microbial Solutions

Tune in for an insightful conversation on the forefront of climate biotechnology, where cutting-edge research meets practical solutions.

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Welcome to The Climate Biotech Podcast hosted by Dan Goodwin. In our inaugural episode, we delve into an enlightening conversation with Brad Zamft, a project lead at Alphabet's Moonshot Factory. Brad shares his remarkable journey from a PhD in neuroscience, through various prestigious roles, to his current pioneering work in plant synthetic biology.

Tune in for an expert-level discussion aimed at identifying the most crucial problems in climate science and discovering innovative solutions to tackle them. This episode promises to inspire and inform anyone passionate about climate biotech and the future of sustainable agriculture.

(00:00) Introduction to the Homeworld Podcast
(01:13) Meet Brad Zamft: From PhD to Moonshot Factory
(01:51) Challenges in Plant Synthetic Biology
(03:57) Brad's Academic Journey and Personal Growth
(09:30) From Academia to Policy: The AAAS Fellowship
(19:59) The Importance of Genetically Engineering Plants
(24:36) Protoplast Transformation and Regeneration
(27:24) Innovative Methods in Plant Transformation
(28:25) State of the Art in Plant Engineering
(30:16) Challenges and Market Limitations
(30:58) Exploring Viral Vectors for Gene Editing
(33:14) Technical Hurdles in Organelle Targeting
(36:10) Metrics and Efficiency in Plant Transformation
(40:59) Future Directions and Open Questions
(46:25) Engaging the Community and Final Thoughts

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