By Research & Innovation
The podcast currently has 67 episodes available.
Asthma is one of the most common conditions - there are 8 million of us in the UK who suffer from it. t can range from the needing a quick puff on your inhaler if you exercise and there’s a lot of pollen about it, to serious, fatal attacks, there’s still a lot we don’t know. That’s what this interview with our respiratory physician Matthew Martin is all about.
One of the things we’re not sure about is to do with how people with inhalers use them - short version, we might doing it all wrong, then again we might not, this is research after all - and that’s what the second bit of the interview you’re about to hear covers.
More on the APEX trial: https://nottinghambrc.nihr.ac.uk/research/respiratory/airway-disease-theme
This bulletin intro was brought to you by Ian Kingsbury from East Genomics Nottingham University Hospitals NHS Trust. Keep listening for more team members introducing other episodes. If you're a clinical researcher at NUH or the University of Nottingham and want to be voice of the podcast contact us at R&[email protected].
#BioResource, #GLADstudy, #NIHR, #Chest drains, #PneumocystisPneumonia, #NottinghamUniversityHospitals
Links
East Genomics – https://www.eastgenomics.nhs.uk/
Join the world's largest study of anxiety & depression - https://gladstudy.org.uk/
PCP – If you are interested in contributing to the development of this research proposal, please contact Vikki Flemming, Consultant Clinical Scientist, Clinical Microbiology, [email protected]
Chest drain - So If you, or someone you care for, has had a chest drain fitted as part of their treatment, please email: [email protected]
BioResource – bioresource.nihr.ac.uk or [email protected]
This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&[email protected].
If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts or Spotify especially. It's For Science.
One of the fundamentals of clinical research is the ‘blind’ bit of the double-blind placebo controlled trial. If neither the researcher nor the participant know whether they’re getting placebo or the drug, it removes the chances that they’re unconsciously responding in the way they think they should.
The placebo effect can account for up to 30% of a difference, so it has to be dealt with.
But if you’re trialling a therapy where the patient will know what’s going on - like exercise for rehab, for example - it can’t be blind. So how do you get round that?
We spoke to clinical research physiotherapist Paul Matthews about the challenges he faced when he was studying exercise as part of rehab for broken ankles.
This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&[email protected].
If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.
The intro this week was from Harriet Anderson, who works in the Research and Innovation team at Nottingham University Hospitals NHS Trust. Keep listening for more team members introducing other episodes. If you're a clinical researcher at NUH or the University of Nottingham and want to be voice of the podcast contact us at R&[email protected].
Links
This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&[email protected].
If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts or Spotify especially. It's For Science.
You’d think that clinical researchers would welcome surprises - but they don’t. Even if the results are new and groundbreaking, they want their trials and studies to run in a predictable, controlled way,.
And that ability to deliver a total lack of surprise is one of the reasons that cancer research at Nottingham University Hospitals NHS Trust has made it into the top flight in the UK working with major pharmaceutical companies.
As well as clinical and scientific excellence, it’s about building up relationships with our partners so that we know we can deliver on recruiting patients, managing the pharmacy needs, and study set up.
The focus is particularly on chemo-free approach to lymphoma treatment, immunotherapy such as CAR T therapy, bispecific antibodies and using data analysis to target treatments.
I talked to Professor Mark Bishton, who’s a consultant haemotologist and the divisional co-lead for research and innovation into cancer and associated. As well as his own research, he’s responsible for delivering the trust’s studies in the specialty.
More information at https://www.nuh.nhs.uk/research-in-cancer
This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&[email protected].
If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.
Staff at the NIHR Nottingham Clinical Research Facility talk about the UCAB trial.
The facility worked with Swedish pharmaceutical Umecrime Cognition to study using a new molecule as a treatment for Primary Biliary Cholangitis (PBC) for patients with severe symptoms of fatigue and cognitive impairment.
Quick takeaways -
• one of only two UK locations for first stage drug trial
• kept to tight, complex timelines
• exceeded recruitment targets by building on existing relationships
• patients praised care and treatment
The NIHR Nottingham Clinical Research Facility (CRF) was one of just two centres worldwide – and the only UK facility – to conduct the first part of a clinical study.
We were picked because of our expertise in liver disease.
We hosted five patients on a purpose-built inpatient ward within the CRF, to confirm the correct dose of the molecule. During their seven-day stay, our team of research nurses and physicians assessed and cared for the patients around the clock.
Nottingham CRF has 18 adult and five paediatric inpatient beds dedicated for research, alongside our dedicated outpatient and specialist clinics. In total, there is over 3,400m² of clinical space at our CRF. The PBC study was a randomised, double-blinded and placebo controlled two-part study to evaluate the pharmacokinetics, safety and tolerability, and preliminary efficacy of two dose levels of the new drug.
There’s more about it at https://nottinghamcrf.nihr.ac.uk/facilities/case-studies
Follow us on Twitter: @NottmBRC
Follow us on Instagram: @NottmHealthScience
Follow us on Facebook: https://www.facebook.com/ResearchNottingham
Watch a video explainer about clinical trials: https://youtu.be/SWS4FCSMWAQ
Read more at https://www.nottinghamresearch.org/get-involved and https://www.nuh.nhs.uk/take-part-in-a-trial and https://www.nuh.nhs.uk/researchvolunteers
Email us at [email protected]
Contacts for his episode:
Bulletin 9 - developing treatments for cystic fibrosis, depression, alcoholic liver disease and eczema
In this episode:
We pick up on presentations from the NIHR Nottingham BRC conference, from:
Our YouTube channel: @NottinghamClinicalResearch
This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&[email protected].
If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.
In this bulletin:
https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3942-nearly-1m-for-pioneering-gene-therapy-formulation-for-bone-graft-augmentation
https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3949-can-innovative-surgery-cut-mortality-after-major-trauma-injuries
In this bulletin:
If you want to stay up to day with the clinical research podcast, you can find us on iTunes, Spotify, Google and where-ever you normally get your podcasts. The more shows are rated and reviewed, the easier it is for search engines to find us, so if you can subscribe and rate and review us, you'll be doing it for science.
This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&[email protected], or visit nuh.nhs.uk/research for more information.
If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially.
The podcast currently has 67 episodes available.