The College of Glycation with Dr. Paul Reynolds

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology—explains how fasting is one of the most powerful and underutilized tools for resetting the glycation burden your body carries. He breaks down how the standard modern eating pattern of frequent, carbohydrate-rich meals drives near-constant glucose and insulin elevations that accelerate the formation of advanced glycation end products (AGEs). These permanent molecular modifications stiffen tissues, trigger inflammation through the RAGE receptor, and fuel the chronic diseases we associate with aging. Dr. Reynolds shows why this damage isn’t inevitable and how fasting interrupts the cycle at its root.He details the profound metabolic shifts that occur when you stop eating insulin drops, the body flips the “metabolic switch” to fat-burning and ketone production, and autophagy—the cellular recycling program—ramps up to clear out damaged, glycated proteins. Drawing on key research, he covers practical approaches including time-restricted eating, early time-restricted feeding, alternate-day fasting, extended fasts, and fasting-mimicking diets. You’ll also learn why how you break a fast matter and how these strategies improve insulin sensitivity, reduce oxidative stress, and enhance metabolic flexibility—independent of weight loss. Whether you’re new to fasting or looking to deepen your practice, this episode delivers a clear, science-backed roadmap for using one of the body’s own repair mechanisms to fight glycation and support long-term health.

Paul’s favorite yerba mate: https://unicity.link/121f260bfe  

Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  

For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  

Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

Your gums may be telling you something critical about your metabolic health. In this episode of the College of Glycation, Dr. Paul Reynolds explores the overlooked connection between gum disease, glycation, and systemic inflammation. He explains how Advanced Glycation End Products (AGEs) form and accumulate—and how periodontal disease doesn’t just result from metabolic dysfunction, but can actively drive it. From inflammatory signaling to insulin resistance, this episode reveals how the mouth plays a central role in whole-body health.

If you’re interested in metabolism, aging, or the deeper biochemical drivers of chronic disease, this episode offers a powerful new perspective on why oral health is far more than cosmetic—it’s metabolic.

Paul’s favorite yerba mate: https://unicity.link/121f260bfe  

Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  

For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  

Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation series, Dr. Paul Reynolds explores how advanced glycation end-products (AGEs) quietly disrupt the body’s hormonal systems. Moving beyond blood sugar alone, he explains how glycation damages key proteins involved in hormone production, transport, and signaling—affecting thyroid function, testosterone levels, insulin sensitivity, and fertility. Even when lab results appear normal, these molecular changes can impair how hormones actually function at the tissue level.

Dr. Reynolds connects the chemistry of glycation to real-world conditions like hypothyroidism, PCOS, infertility, and metabolic dysfunction, while introducing the RAGE pathway as a major driver of chronic inflammation and hormonal imbalance. This episode offers a deeper framework for understanding the link between diet, metabolic health, and endocrine function—and what you can do to reduce glycation and protect long-term health.

Paul’s favorite yerba mate: https://unicity.link/121f260bfe  

Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  

For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  

Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds explores a major blind spot in metabolic health: fructose. While most discussions around sugar focus on glucose and blood sugar levels, this episode reveals why fructose may be even more damaging. Dr. Reynolds explains how fructose is metabolized almost entirely in the liver, bypassing key regulatory systems and driving fat production, insulin resistance, and oxidative stress. More importantly, fructose is significantly more reactive in the glycation process—accelerating the formation of advanced glycation end-products (AGEs) that damage tissues and promote chronic disease.

Building on foundational glycation science, this episode uncovers how fructose not only glycates proteins faster than glucose but also generates highly reactive compounds like methylglyoxal, amplifying cellular damage. Dr. Reynolds challenges common assumptions about “healthy” sugars found in fruit juice and natural sweeteners, offering a clearer understanding of how modern dietary patterns contribute to long-term metabolic dysfunction.

Paul’s favorite yerba mate: https://unicity.link/121f260bfe  

Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  

For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  

Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds introduces the foundational science of glycation—one of the most important and underrecognized processes driving aging and chronic disease. He explains how glucose, while essential for energy, can also react with proteins in the body through a non-enzymatic process that gradually leads to the formation of advanced glycation end-products (AGEs). Using clear analogies and step-by-step explanations, Dr. Reynolds walks through how glycation begins, how it progresses, and why its effects accumulate silently over time in tissues like blood vessels, kidneys, nerves, and eyes.

This episode also explores the real-world implications of glycation in modern health, highlighting how lifestyle factors—such as diet, cooking methods, physical inactivity, and chronically elevated blood sugar—accelerate the process beyond what the body can manage. Dr. Reynolds outlines the body’s natural defense systems and, more importantly, the practical steps individuals can take to reduce glycation burden, improve metabolic health, and slow the long-term trajectory of aging and disease.

Paul’s favorite yerba mate: https://unicity.link/121f260bfe  

Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  

For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  

Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds explores one of the most important questions in metabolic health: Is glycation reversible? While some damage—especially in long-lived tissues like collagen—can persist for decades, this episode reveals that the body is far from helpless. Dr. Reynolds breaks down the science of how glycation forms, why certain stages are more reversible than others, and the built-in systems your body uses to defend against and clear this damage.

More importantly, he translates that science into practical strategies you can use right away. From improving blood sugar control and reducing dietary AGEs to leveraging fasting, exercise, and targeted supplementation, this episode reframes the goal—not as fully reversing damage, but as slowing its accumulation and changing your long-term health trajectory.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

In this episode of the College of Glycation, Dr. Paul Reynolds explores a growing concern among health-conscious individuals: whether even “healthy” foods may be contributing to glycation and long-term metabolic damage. Prompted by real audience questions, he unpacks the science of advanced glycation end products (AGEs) with a focus on those introduced through diet, revealing that the true driver of AGE content is often not the food itself—but how it’s prepared.

Drawing on decades of research, Dr. Reynolds explains how cooking methods like roasting and grilling dramatically increase AGE formation compared to lower-temperature, moisture-rich methods like boiling or steaming. He also breaks down how the body absorbs, processes, and clears dietary AGEs, and why metabolic health plays a central role in determining overall AGE burden. The episode delivers practical, evidence-based strategies to reduce glycation exposure—offering clarity and control to anyone looking to support long-term health and reduce inflammation at the molecular level.

Paul’s favorite yerba mate: https://unicity.link/121f260bfe  

Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  

For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  

Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds explores how glycation—long understood as a driver of aging and metabolic disease—may also underlie a range of specialized health conditions that often go unexplained. Moving beyond theory, he connects the biochemical process of advanced glycation end product (AGE) formation to real-world issues like frozen shoulder, vertigo, and MTHFR-related metabolic dysfunction. By breaking down how glycation alters long-lived proteins such as collagen, myelin, and vascular tissues, Dr. Reynolds reveals how a single molecular process can manifest across joints, nerves, and the inner ear.

Drawing on peer-reviewed research and clear physiological explanations, this episode reframes seemingly unrelated diagnoses through a unified metabolic lens. You’ll gain insight into how glycation and homocysteine-driven protein damage may work together to accelerate dysfunction, why these processes often go undetected in standard clinical testing, and what this means for long-term health. Whether you’re dealing with chronic joint pain, unexplained neurological symptoms, or genetic findings like MTHFR, this conversation offers a deeper understanding of the hidden biochemical patterns shaping your health.

Paul’s favorite yerba mate: https://unicity.link/121f260bfe  

Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  

For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  

Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)