The DeSci Podcast

Welcome to another episode of the DeSci Podcast. In this episode, Michael Gibson, co-founder and general partner of the 1517 fund, author of the new book ‘Paper Belt on Fire: How Renegade Investors Sparked a Revolt Against the University’ and one of the key people involved in launching the Thiel Fellowship in 2010 (where he helped Vitalik Buterin shape Ethereum), tells us about his vision of legacy institutions and how we can modernize them to encourage great global innovations once again.  

You can already get his excellent book, discussed in the episode, on Amazon: https://www.amazon.com/Paper-Belt-Fire-Fight-Progress-ebook/dp/B099FZR4C3 

Navigate through the topics discussed in this podcast using the timestamps below.

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⭐ Timestamps: 

0:00 Intro

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If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected] 

Special thanks to:  

Sebastian Brunemeier (Host): https://twitter.com/sebastian_gero  

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Let's connect:  

Website: https://bit.ly/3d6nh2C

Today we have a special one! In this episode, we have Vitalik Buterin as a guest, interviewed by Vincent Weisser. 

They discuss the intersection of science and cryptocurrency, focusing on the concept of "decentralized science."  Vitalik explains how decentralized technologies, such as cryptocurrency, can improve science and the institutions of science by allowing for more diverse funding and collaboration among people.

He also mentions specific tools, such as quadratic funding and decentralized autonomous organizations (DAOs), that can be used to fund and structure scientific projects.   He also highlights his current project, "Balvi", which is focused on addressing the COVID-19 situation and is funded by cryptocurrency.

There is undoubtedly much more to be found in this episode and we hope you enjoy this conversation between Vitalik Buterin and Vincent Weisser. Make sure to skip between the timestamps below to find your favorite topics and learn more about the discussed topics through all the linked resources below.

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Some of the resources discussed. 

- Vitaliks blog: https://vitalik.ca/

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Timestamps:  

00:00 - 00:37 Intro

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Let's connect:  

Website: https://bit.ly/3d6nh2CTwitter:

Welcome to another episode of the DeSci Podcast. In this episode, Stanley Bishop, AKA Science Stanley, data scientist and head of data science at LabDAO talks about AI, what it means to be a data scientist and how it intersects with decentralized approaches. We also talk about how this can be applied across individual health, collective health, the planets, genome sequencing and language models and what this could mean for the future of the organization and the future of work.  

Stanley Bishop also talks about LabDAO’s collaboration with "Research to the People" in order to build an integrated and traditional data marketplace where treatments can be shared between physicians so they can compare notes and figure out the best clinical path for their patients which can be impactful for patients that might have rare or complex conditions, New Atlantis DAO and its mission to provide a solution for climate change and many more.  

Navigate through the topics discussed in this podcast using the timestamps below.

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Timestamps:  

0:00 Intro

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If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]  

Special thanks to:  

Erin Magennis (Host): https://twitter.com/erinmagennis

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Let's connect:  

Website: https://bit.ly/3d6nh2C

Welcome to episode Nr. 7 of the DeSci Podcast! In this episode, Tyler Golato, Co-founder and CSO of Molecule DAO joins us as we discuss the problems of scientific research and funding and necessary changes that need to be made in the way funding is done.  

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Timestamps:   

0:40 Background story of Tyler Golato.

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If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]  

Special thanks to:  

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Let's connect:  

Website: https://bit.ly/3d6nh2C

Molecule - The future of medicine belongs to everyone

Welcome to episode Nr. 6 of "The DeSci Podcast"! In this episode, Patrick Malone, a physician-scientist turned investor at KDT Ventures where he invests in early-stage life science and healthcare, tells us about what drove his interest in investing in healthcare, what Tech-Bio is, and how it relates to the traditional understanding of Biotech. 

He also explains, why machine learning is effective in drug discovery, the biggest problem facing scientific research and funding models today, the future of scientific research, and much more. Patrick Malone argued that rewarding negative findings which help to discover what doesn’t work or what isn’t true in a previous research publication will greatly reduce the problem of reproducibility.   

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. 

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Timestamps:  

0:00 Intro

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If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]  

Special thanks to:   

Alex LaBossiere (Host): https://twitter.com/adlabossiere

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Let's connect:  

Website: https://bit.ly/3d6nh2C

Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 5 of the DeSci Podcast! In this Episode, Allison Duettmann, President and CEO of Foresight Institute tells us how she got into futurism, why people are so pessimistic about the future, how Foresight chose the most important things to work on, Allison's positive visions of the future for humanity, what are Tech Trees and more! We hope you enjoy!  

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Timestamps: 

0:00 - Nanobots & Cryonics

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Links mentioned:  

Balaji on Tech Trees: https://twitter.com/balajis/status/1456163613857570821?s=20&t=XP1sJ8gBEKNw-V7fPHsNpw

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Notable quotes from Allison: 

"I got interested in Technologies through a wish for a longer happier life for myself and for civilization."  

"Despite the fact that life has been improving pretty steadily over the last hundreds of thousands of years, our realization that it has been has not been steadily adjusting. Most of the time if you ask around people think that things are getting worse, that violence is increasing, and pretty substantial societal flaws are increasing and so I think it doesn't often match with the actual improvement in living conditions that many of us were fortunate enough to receive over the past few hundred thousand years."   

"A positive outlook I think starts with a gratitude for how far we've come and just realizing what our ancestors put forth and how much they paid forward for us to get to where we are."  

"Rather than having this more default vision on the future of what would the path be in which we all self-destruct (which is certainly a morbid fantasy) which is easier to think about and somehow weirdly more attractive to our human minds actually, rather asking the other question of what would it mean to actively put a foundation in place in which we could build wonderful worlds."  

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If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.  If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]  

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Let's connect:  

Website: https://bit.ly/3d6nh2C

Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 4 of the DeSci Podcast - Today we're exploring the decentralized science space together with Jack Scannell! Jack coined the term Eroom's Law, which notes that the cost of new drug approvals is rising exponentially, in contrast to Moore's law, which notes that the number of transistors on a microchip doubles about every two years, though the cost of computers is halved.  

In this podcast, Jack talks about how we can do better drug discovery, specifically, the tools and frameworks we can use to choose the right drug discovery model and feed that into investment decisions. His new paper in Nature Reviews Drug Discovery addresses exactly that: https://rdcu.be/cWTtO 

In this podcast, Jack argues that quality beats quantity when it comes to assays, but actually the best thing is quality AND quantity. So it's better to test a small number of therapeutic candidates in a really good model than it is to test a very large number of computer candidates selected from the same universe in a model of low validity - the best example of this is in antimicrobials discovered around 1930 by Gerhard Domagk. Jacks says that the model validity used in Germany in the 1930's is better than the model validity used in the early 90's.  

The technological barrier in drug R&D has shifted from chemistry to effectively the tools that tell you whether or not that chemistry is useful. It's not that we can't make compounds, we probably can in many cases make those compounds but what we can't do is we can't distinguish the ones that do something useful from the ones that don't. It's not that we can't identify targets, we can, but we can't tell the good ones from the bad ones - so the critical resource in drug R&D is probably the models, which Jack's paper calls "decision tools" that let you sift the good stuff from the bad stuff.   

Jack on what interested him about VitaDAO and Molecule: You create value not by making current markets a little bit more efficient, you create value by making markets exist where none existed before. Outside of a few well-ventured universities, universities are terribly under-ventured and also the people at those universities don't have the right tools to present their material in such a way that it could be ventured so it struck him that providing a low transaction cost, standardized platform to make an eBay for IP might be an extremely valuable thing to do because you could create markets where none existed before.

Important links mentioned in the episode:

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A huge thanks again to Sebastian and Jack for taking the time and for the valuable input - We hope you all can take something away from this episode on your DeSci journey.  If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]  

You'll also find all links to YouTube, Discord, Twitter and our website via the following link - https://linktr.ee/thedescipodcast

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Special thanks to:   

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Let's connect:  

Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 3 of the DeSci Podcast - Today we're exploring the decentralized science space together with our CEO of Molecule and Vincent Weisser, our Chief Ecosystem Officer!  

We're incredibly proud to finally speak in depth about our new project bio.xyz - Next to that, we are also digging into a lot of other interesting decentralized science topics. You can find all of them below, so you can skip around to find your favorite ones!   

Topics & Timestamps:  

00:00 - Intro  

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A huge thanks again to Vincent & Paul for taking the time and for the valuable input - We hope you all can take something away from this episode on your DeSci journey.  Feel free to skip around the timestamps to find your favorite topics and thanks again for tuning in!

You'll also find all links to YouTube, Discord, Twitter and our website on linktree here - https://linktr.ee/thedescipodcast

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Special thanks to:   

Alex LaBossiere (Host): https://twitter.com/adlabossiere

Find out more about bio.xyz here:  

Website: https://www.bio.xyz/

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Let's connect:  

Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 2 of the DeSci Podcast - Today we're exploring the decentralized science reformation together with no other than Balaji Srinivasan! We're incredibly proud to be joined by such a smart and well-known mind as a second guest on "The DeSci Podcast" show!    

Topics of this episode:  

Due to his nature, we're slipping in many other interesting topics while tackling those above! 💙  

Feel free to skip around the timestamps to find your favorite topics and thanks again for tuning in! Also, if you prefer listening to podcasts on audio apps, feel free to search for "How To DeSci" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps and the show-notes below.   

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]  

Special thanks to:   

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Timestamps:  

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Show-notes of the episode:   

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Let's connect:  

Welcome to the very first episode of "The DeSci Podcast" - On this show, we talk to the leaders of the decentralized science world about the future of biotech. Thanks for being here and enjoy the very first episode of this new podcast, brought to you by Molecule.  

In this first episode, we talk to Tim Peterson, Sebastian Brunemeier & Laurence Ion from  @VitaDAO  - VitaDAO is the first ever created BioDAO and just recently celebrated its first year anniversary. So we wanted to know - What where the challenges and learnings of this year? How does the future look like in this space and what even is VitaDAO and DeSci?   

Feel free to skip around the timestamps to find your favorite topic and thanks again for tuning in! Also, if you prefer listening to podcasts on audio apps, feel free to search for "How To DeSci" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links below.   

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at [email protected]  

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Thanks to today guests of todays show:   

Alex LaBossiere (Host): https://twitter.com/adlabossiere

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Timestamps: 

00:00 - Intro  

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Let's connect:  

Website: https://www.molecule.to/