The Diabuddies -Holistic Diabetes Management and Functional Medicine

The Diabuddies -Holistic Diabetes Management and Functional Medicine

By Dr. Grady Donohoe and Dr. Garrett PannoAlternative HealthHealth & FitnessNutrition
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The Diabuddies -Holistic Diabetes Management and Functional Medicine episodes

  • #9 THE DIAGNOSIS

    Join Dr. Grady and Garrett on this episode of The Diabuddies Podcast as they discuss their diagnosis stories, as well as conversations on Diabetic Ketoacidosis (DKA), fasting, and deeper conversations on identity, self-worth, and how one defines themself.

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    1 hr 5 min
  • #8 Carbohydrates

    Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

    In this episode, we discuss all things carbohydrates including glycemic index, glycemic load, simple vs complex carbs, fiber, fructose, and sugar alcohols. Most importantly, we talk about how to take this information into account when dosing insulin. We top it off with a segment on what #BurstMyBetaCells.

     

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    Resources/Links Discussed in the episode:

    Glycemicindex.com 

    1 hr 6 min
  • #7 The Importance of Tight Blood Sugar Control

    Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

    In this episode, we discuss why it is important for us to maintain good blood sugar control. We talk about the immediate benefits of good blood sugar levels such as sleep, mental and physical performance, and brainpower. We also get into the long-term considerations of maintaining tight blood sugar control like circulation, eyes, and kidney health. 

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    Resources/Links Discussed in the episode:

    “The Diabetes Control and Complications Trial (DCCT): Design and Methodologic Considerations for the Feasibility Phase.” Diabetes, vol. 35, no. 5, 1986, pp. 530–545., doi:10.2337/diab.35.5.530.

    Gaete, Ximena, et al. “Menstrual Cycle Irregularities and Their Relationship with HbA1c and Insulin Dose in Adolescents with Type 1 Diabetes Mellitus.” Fertility and Sterility, vol. 94, no. 5, 2010, pp. 1822–1826., doi:10.1016/j.fertnstert.2009.08.039.

    Huang, Chun-Jen, et al. “Prevalence and Incidence of Diagnosed Depression Disorders in Patients with Diabetes: a National Population-Based Cohort Study.” General Hospital Psychiatry, vol. 34, no. 3, 2012, pp. 242–248., doi:10.1016/j.genhosppsych.2011.12.011.

    King, Paromita, et al. “The UK Prospective Diabetes Study (UKPDS): Clinical and Therapeutic Implications for Type 2 Diabetes.” British Journal of Clinical Pharmacology, vol. 48, no. 5, 2001, pp. 643–648., doi:10.1046/j.1365-2125.1999.00092.x.

    1 hr 20 min
  • #6 Dysglycemia and Brain Health

    #6 Dysglycemia and Brain Health

    Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

    In this episode, Dr. Donohoe and Garrett discuss poor blood sugar control in the non-diabetic person and the importance of recognizing blood sugar instability. Along those lines, we talk about the role that dysglycemia has in the development of issues with brain function, from brain fog to Alzheimer’s.

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    Resources/Links Discussed in the episode:

    • Barbagallo, M., & Dominguez, L., (2014). Type 2 diabetes mellitus and Alzheimer’s disease. World Journal of Diabetes; 5(6): 889-893.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265876/
  • Janson J., Laedtke, T., Parisi, J.E., O’Brien, P., Petersen, R.C., & Butler, P.C., (2004). Increased risk of type 2 Diabetes in Alzheimer disease. Diabetes; 53(2): 474-481.
    • https://www.ncbi.nlm.nih.gov/pubmed/14747300
  • Arvanitakis, Z., Wilson, RS., Brienias, J.L., Evans, D.A., & Bennett, D.A., (2004). Diabetes mellitus and risk of ALzheimer disease and decline in cognitive function. Arch Neurol; 61(5): 661-666.
    • https://www.ncbi.nlm.nih.gov/pubmed/15148141
  • Wu, William, et al. “The Brain in the Age of Old: The Hippocampal Formation Is Targeted Differentially by Diseases of Late Life.” Annals of Neurology, vol. 64, no. 6, 2008, pp. 698–706., doi:10.1002/ana.21557.
  • Peixoto, Christina Alves, et al. “AMPK Activation: Role in the Signaling Pathways of Neuroinflammation and Neurodegeneration.” Experimental Neurology, vol. 298, 2017, pp. 31–41., doi:10.1016/j.expneurol.2017.08.013.
    • 54 min
  • #5 Management of Type 2 Diabetes

    Episode #5 Management of Type 2 Diabetes

    Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

    In this episode, Dr. Donohoe and Garrett discuss the management of Type 2 Diabetes and the mechanisms of how diet and exercise are such powerful tools when trying to achieve optimal blood glucose levels. We also get into sleep and stress management in regards to blood sugar.

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    Resources/Links Discussed in the episode:

    Richter, E.A., & Hargreaves, M., (2013). Exercise, GLUT4, and Skeletal Muscle Glucose Uptake. Physiological Reviews; 93(3):993-1017. https://www.physiology.org/doi/full/10.1152/physrev.00038.2012?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
  • Niu, Y., et al., (2017). Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner. BBA Molecular Basis of Disease; 1863(9):2372-2381 https://www.sciencedirect.com/science/article/pii/S092544391730220X?via%3Dihub
  • Yin, J., Xing, H., & Ye, J., (2008). Efficacy of Berberine in Patients with Type 2 Diabetes. Metabolism; 57(5): 712-717. https://www.ncbi.nlm.nih.gov/pubmed/18442638
    • Wang, H., Zhu, C., Ying, Y., Luo, L., Huang, D., & Luo, Z., (2018). Metformin and berberine, two versatile drugs in the treatment of common metabolic diseases. Oncotarget; 9(11): 10135-10146.
    https://www.ncbi.nlm.nih.gov/pubmed/29515798
  • De Souza, JFT., Dattilo, M., de Mello, MT., Tuflk, S.,&  Antunes, HKM (2017). High-Intensity Interval Training Attenuates Insulin Resistance Induced by Sleep Deprivation in Healthy Males. Front Physiol; 8: 992.
    • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725446/
  • Ahmed, A. Bakrudeen Ali, et al. “In Vitro Callus and in Vivo Leaf Extract of Gymnema Sylvestre Stimulate β-Cells Regeneration and Anti-Diabetic Activity in Wistar Rats.” Phytomedicine, vol. 17, no. 13, 2010, pp. 1033–1039., doi:10.1016/j.phymed.2010.03.019.
  • Al‐Romaiyan, Altaf, et al. “A Novel            Gymnema Sylvestre Extract Protects Pancreatic Beta‐Cells from Cytokine‐Induced Apoptosis.” Phytotherapy Research, 2019, doi:10.1002/ptr.6512.
  • Kuo, Daih-Huang, et al. “Body Weight Management Effect of Burdock (Arctium Lappa L.) Root Is Associated with the Activation of AMP-Activated Protein Kinase in Human HepG2 Cells.” Food Chemistry, vol. 134, no. 3, 2012, pp. 1320–1326., doi:10.1016/j.foodchem.2012.03.023.
  • Lan, Jiarong, et al. “Meta-Analysis of the Effect and Safety of Berberine in the Treatment of Type 2 Diabetes Mellitus, Hyperlipemia and Hypertension.” Journal of Ethnopharmacology, vol. 161, 2015, pp. 69–81., doi:10.1016/j.jep.2014.09.049.
  • Lee, Woo Je. “α-Lipoic Acid Increases Insulin Sensitivity by Activating AMPK in Skeletal Muscle.” Biochemical and Biophysical Research Communications, vol. 332, no. 3, 2005, pp. 885–891., doi:10.1016/j.bbrc.2005.05.035.
  • Magistrelli, Ashley, and Jo Carol Chezem. “Effect of Ground Cinnamon on Postprandial Blood Glucose Concentration in Normal-Weight and Obese Adults.” Journal of the Academy of Nutrition and Dietetics, vol. 112, no. 11, 2012, pp. 1806–1809., doi:10.1016/j.jand.2012.07.037.
  • Viollet, Benoit. “Targeting the AMPK Pathway for the Treatment of Type 2 Diabetes.” Frontiers in Bioscience, Volume, no. 14, 2009, p. 3380., doi:10.2741/3460.
  • Wei, Wei, et al. “A Clinical Study on the Short-Term Effect of Berberine in Comparison to Metformin on the Metabolic Characteristics of Women with Polycystic Ovary Syndrome.” European Journal of Endocrinology, vol. 166, no. 1, 2012, pp. 99–105., doi:10.1530/eje-11-0616.
    • 40 min
  • #4 What is Type 2 Diabetes?

    Episode 4: What is Type 2 Diabetes?

    Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

    • In this episode, we discuss what Type 2 Diabetes is and how it develops. We then get into various factors that contribute to the high blood sugar and insulin resistance involved in Type 2 Diabetes. We also go over the many organ systems that are affected by Type 2 Diabetes. We conclude by sharing a "Freedom Moment" that we recently had with our diabetes.

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    You can email us at [email protected]

     

    Resources/Links Discussed in the episode:

    • Shi, X., et al., (2016). Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis. Nutrition Journal; 15: 103. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192567/
  • Petersen, M.C., & Shulman, G.I., (2018). Mechanisms of Insulin Action and Insulin Resistance. Physiology Reviews; 98(4): 2133–2223. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170977/
  • Burhans, M.C., et al., (2018). Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus. Compr Physiol; 9(1): 1–58.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557583/
    • 39 min
  • #3 Management of Type 1 Diabetes

    Episode 3: Management of Type 1 Diabetes

    Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

    • In this episode, we discuss the management of Type 1 Diabetes which includes: shots vs pumps, the different types of insulin, CGMs and the importance of checking blood glucose frequently. We also get into the importance of sleep, diet, and exercise. To conclude, Garrett and Dr. Grady each share a challenge that they recently faced with their diabetes and how they were able to overcome it and what they learned from it. 

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    You can email us at [email protected]

    1 hr 1 min
  • #2 What is Type 1 Diabetes?

    Episode 2: What is Type 1 Diabetes?

    Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

    • In this episode, we discuss what Type 1 Diabetes is and how it develops. We also talk about insulin and how it works. To conclude, we go over the challenges that Type 1 Diabetics face and what really "Burst My Beta Cells".

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    You can email us at [email protected]

    Resources/Links Discussed in the episode:

    • Mincu, I., Ionescu-Tigoviste, C., (1980). Half-life and hypoglycemic effect of intravenous insulin in patients with diabetic ketoacidosis. Med Interne; 18(3): 287-292. https://www.ncbi.nlm.nih.gov/pubmed/6774410
    36 min
  • #1 Introduction

    Episode 1: Introduction

    Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

    PLEASE SUBSCRIBE TO THE PODCAST

    For more Diabuddies content follow us on The Diabuddies Podcast Facebook page.

    Twitter: @TheDiabuddies

    Instagram: @thediabuddiespodcast

    You can email us at [email protected]

     

    Resources/Links Discussed in the episode:

    • Gavrilova, O., et al., (2000). Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. The journal of clinical investigation; 105(3): 271–278. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC377444/
    28 min

About The Diabuddies -Holistic Diabetes Management and Functional Medicine

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Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about a holistic approach to blood sugar management, overall health, and how to take control of your health to gain the freedom to live…