For the fifth time in program post-season history Mississippi State starts NCAA Tournament play in the Tallahassee Regional. The previous four trips have produced championships in 2007 and 2018, with both clubs advancing ultimately to the College World Series. The Diamond Dogs face runaway CAA champs Northeastern, while #9 national seed Florida State faces Bethune-Cookman. The regional is paired with the Corvallis tournament and #8 seed Oregon State.

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