In this episode of Functional Medicine Unlocked, Dr. Miiko Rowley sits down with Dr. Lawrence Kosinski, a Gastroenterologist and Medical Director of Jona Health, to break down what the gut microbiome actually is and why it matters for nearly every system in your body.
With over 35 years of clinical GI experience and 25,000+ colonoscopies performed, Dr. Kosinski explains how trillions of microorganisms living in your colon influence digestion, immunity, brain function, and even long term disease risk.
We cover what prebiotics, probiotics, and postbiotics mean, how short chain fatty acids like butyrate and propionate affect your gut lining, immune system, and even your own GLP1 production, and why symptoms like bloating, fatigue, and brain fog can trace back to an imbalanced microbiome even when standard tests come back normal.
Dr. Kosinski also shares how AI powered shotgun metagenomic testing is changing the way physicians assess and treat patients, and how tools like digital twins and personalized action plans are making this science usable in everyday clinical care.
Timestamps
0:00 Introduction: what is the gut microbiome
2:02 How the microbiome forms and why we need it
5:35 Prebiotics, probiotics, and postbiotics explained
7:58 Short chain fatty acids and the gut barrier
10:28 How gut health connects to brain fog, mood, and immunity
15:43 Why gut health is different for everyone
17:32 Why symptoms alone don't give a clear diagnosis
21:07 Real patient case: IBS vs IBD
23:32 A sneak peek at ViavAc, a new sensor based breath test
25:10 Inside advanced microbiome testing and AI analysis
30:29 Has microbiome testing outpaced the science?
32:26 Where conventional and functional medicine are aligning
36:21 Why this testing became part of Dr. Rowley's practice
38:20 The digital twin and personalized action plans
41:15 Why general AI chatbots fall short for gut health
44:45 Final thoughts: listen to your gut
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To learn more about Jona Health
visit: https://jona.health
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Lawrence Kosinski, MD
LinkedIn: https://www.linkedin.com/in/lawrence-kosinski-17308910/
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Miiko Rowley, MD | Medical Director, Kale Functional Medicine
Website: https://kalemd.com
LinkedIn: https://www.linkedin.com/in/miiko-richardson-rowley-md-abfm-ifmcp-357278a/
The Menopause Mentor: https://kalemd.com/master-your-menopause-journey/
Shop Supplements: https://shop.kalemd.com
Shop Labs: kale.wellproz.com/patient/home
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Disclaimer: The Dr. Miiko Rowley Show: Functional Medicine Unlocked is presented for entertainment and general informational purposes only and is not intended to constitute medical advice, diagnosis, treatment, or individualized clinical guidance. Please consult with your qualified healthcare professional regarding any questions or concerns about your health.