Not all PCOS is created equal. In this solo episode of The Egg Factor, CHR’s Medical Director Dr. Norbert Gleicher dives into one of the most misunderstood—and frequently missed—diagnoses in reproductive medicine: lean PCOS with low androgens, also known as D-phenotype PCOS.

Often overlooked because these patients don’t fit the “typical” PCOS profile, women with D-phenotype are usually thin, have regular periods, and no obvious signs of excess androgens. But as they age—especially after 35—their androgen levels decline dramatically, quietly sabotaging their fertility. Many are prescribed inositol supplements that could actually make things worse.

Dr. Gleicher unpacks the science behind this phenotype, explains why standard protocols fall short, and offers guidance on how to recognize and treat this subtle but significant hormonal imbalance.

If you’ve been diagnosed with PCOS but don’t quite relate to the usual symptoms—or you’ve been told everything looks “normal” despite ongoing fertility struggles—this episode is a must-listen.

Available now on Spotify, Apple Podcasts, and all major podcast platforms.

Brought to you by the Center for Human Reproduction (CHR) on the Upper East Side of New York City. With over 40 years of experience and a history of innovation, CHR has been at the forefront of fertility care since the beginning. 

Our founder, Dr. Norbert Gleicher, reported the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes. At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

Website: www.thechr.com 

Facebook: https://www.facebook.com/chrnewyork 

Instagram: https://www.instagram.com/chrnewyork/ 

Linkedin:  https://www.linkedin.com/company/centerforhumanreproduction/ 

Pinterest: https://www.pinterest.com/CenterforHumanReproduction/ 

TikTok: https://www.tiktok.com/@chrnewyork

In this solo episode of The Egg Factor, Dr. Norbert Gleicher, Medical Director of CHR, unpacks the complex relationship between nutrition, inflammation, insulin resistance, and reproductive outcomes in women over 40. Drawing on decades of clinical and research experience, Dr. Gleicher dives into how specific micronutrients and metabolic factors influence egg quality, implantation, and miscarriage risk. 

Our founder, Dr. Norbert Gleicher, reported the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes. At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

Website: www.thechr.com 

Facebook: https://www.facebook.com/chrnewyork 

Instagram: https://www.instagram.com/chrnewyork/ 

Linkedin:  https://www.linkedin.com/company/centerforhumanreproduction/ 

Pinterest: https://www.pinterest.com/CenterforHumanReproduction/ 

TikTok: https://www.tiktok.com/@chrnewyork

We’ve all heard it: after 40, your chances of conceiving with your own eggs plummet. But is the data behind the so-called "fertility cliff" as clear-cut as it seems?

In this episode of The Egg Factor, CHR's Dr. Norbert Gleicher unpacks research, clinical experience, and patient outcomes to challenge the mainstream narrative. He explores how fertility statistics have been widely misinterpreted, why donor eggs are often recommended too quickly, and what ovarian potential really looks like in women over 40.

If you’ve been told your only option is egg donation—or you’re wondering whether age alone should determine your treatment path—this conversation is for you.

Listen now on Spotify, Apple Podcasts, or wherever you get your podcasts.

Brought to you by the Center for Human Reproduction (CHR) on the Upper East Side of New York City. With over 40 years of experience and a history of innovation, CHR has been at the forefront of fertility care since the beginning. 

Our founder, Dr. Norbert Gleicher, reported the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes. At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

Website: www.thechr.com 

Facebook: https://www.facebook.com/chrnewyork 

Instagram: https://www.instagram.com/chrnewyork/ 

Linkedin:  https://www.linkedin.com/company/centerforhumanreproduction/ 

Pinterest: https://www.pinterest.com/CenterforHumanReproduction/ 

TikTok: https://www.tiktok.com/@chrnewyork

We often hear about the biological clock—but what does “ovarian aging” really mean? In this episode of The Egg Factor, Dr. Norbert Gleicher and Dr. David Barad explain the science behind ovarian aging, how it differs from chronological age, and what it means for fertility—especially for women in their late 30s, 40s, or those diagnosed with low ovarian reserve.

Brought to you by the Center for Human Reproduction (CHR) on the Upper East Side of New York City. With over 40 years of experience and a history of innovation, CHR has been at the forefront of fertility care since the beginning. 

Our founder, Dr. Norbert Gleicher, reported the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes. At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

Website: www.thechr.com 

Facebook: https://www.facebook.com/chrnewyork 

Instagram: https://www.instagram.com/chrnewyork/ 

Linkedin:  https://www.linkedin.com/company/centerforhumanreproduction/ 

Pinterest: https://www.pinterest.com/CenterforHumanReproduction/ 

TikTok: https://www.tiktok.com/@chrnewyork

What really happens behind the microscope?

In this episode of The Egg Factor, Dr. Norbert Gleicher, Dr. David Barad, and world-renowned embryologist Dr. David Albertini take you inside the fertility lab to demystify some of the most misunderstood parts of the IVF process.

They break down:
-How embryos are graded—and what those grades actually mean
-What exactly about morphology is important
-The truth about PGT-A (and whether it improves your chances)
-How many times can you freeze a human embryo? 

Why CHR often works with embryos other clinics would discard

Whether you’re preparing for your first cycle or navigating a complicated fertility journey, this conversation will give you the tools to better understand your options—and advocate for the care you deserve.

Brought to you by the Center for Human Reproduction (CHR) on the Upper East Side of New York City. With over 40 years of experience and a history of innovation, CHR has been at the forefront of fertility care since the beginning. 

Our founder, Dr. Norbert Gleicher, reported the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes. At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

Website: www.thechr.com 

Facebook: https://www.facebook.com/chrnewyork 

Instagram: https://www.instagram.com/chrnewyork/ 

Linkedin:  https://www.linkedin.com/company/centerforhumanreproduction/ 

Pinterest: https://www.pinterest.com/CenterforHumanReproduction/ 

TikTok: https://www.tiktok.com/@chrnewyork

In this episode of The Egg Factor, Dr. Norbert Gleicher, Dr. David Barad, and Dr. David Albertini unpack one of the most controversial topics in reproductive medicine today: Three-Person IVF—also known as mitochondrial replacement therapy.

Together, they break down:

- What “three-parent embryos” actually are
- The science behind mitochondrial transfer
- Why this technique is currently banned by the FDA
- And the serious ethical and biological concerns it raises

While headlines might portray it as a breakthrough, CHR’s team sees it differently. Tune in for a grounded, science-based conversation about why this experimental method isn't the solution it's being marketed to be—and what real innovation in fertility care should look like.

Brought to you by the Center for Human Reproduction (CHR) on the Upper East Side of New York City. With over 40 years of experience and a history of innovation, CHR has been at the forefront of fertility care since the beginning. 

Our founder, Dr. Norbert Gleicher, reported the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes.
At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

Website: www.thechr.com 
Facebook: https://www.facebook.com/chrnewyork 
Instagram: https://www.instagram.com/chrnewyork/ 
Linkedin:  https://www.linkedin.com/company/centerforhumanreproduction/ 
Pinterest: https://www.pinterest.com/CenterforHumanReproduction/ 
TikTok: https://www.tiktok.com/@chrnewyork

In this listener-driven Q&A episode of The Egg Factor, CHR’s Dr. Norbert Gleicher and Dr. David Barad answer two critical questions from our patient community. First up: If you're doing a Day 3 frozen embryo transfer (FET) and had no choice—should you opt for a medicated or modified natural cycle? Then, the doctors tackle a question that weighs heavily on many: What are the most common chromosomal abnormalities seen in women 40 and older, and how do they impact fertility treatment?

Known for their candor and decades of clinical experience, Dr. Gleicher and Dr. Barad break down the science behind these decisions and offer guidance for navigating the complex path to parenthood later in life.

Brought to you by the Center for Human Reproduction (CHR) on the Upper East Side of New York City. With over 40 years of experience and a history of innovation, CHR has been at the forefront of fertility care since the beginning. 

Our founder, Dr. Norbert Gleicher, reported the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes. At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

Website: www.thechr.com 

Facebook: https://www.facebook.com/chrnewyork 

Instagram: https://www.instagram.com/chrnewyork/ 

Linkedin:  https://www.linkedin.com/company/centerforhumanreproduction/ 

Pinterest: https://www.pinterest.com/CenterforHumanReproduction/ 

TikTok: https://www.tiktok.com/@chrnewyork

With headlines swirling about legal threats to IVF and fertility treatment, many patients are left feeling anxious and uncertain. In this episode of The Egg Factor, Dr. Norbert Gleicher and Dr. David Barad break down the recent legislative developments—and what they actually mean for fertility care in the U.S.

Brought to you by the Center for Human Reproduction (CHR) on the Upper East Side of New York City. With over 40 years of experience and a history of innovation, CHR has been at the forefront of fertility care since the beginning. 

Our founder, Dr. Norbert Gleicher, performed the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes. At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

Website: www.thechr.com 

Facebook: https://www.facebook.com/chrnewyork 

Instagram: https://www.instagram.com/chrnewyork/ 

Linkedin:  https://www.linkedin.com/company/centerforhumanreproduction/ 

Pinterest: https://www.pinterest.com/CenterforHumanReproduction/ 

TikTok: https://www.tiktok.com/@chrnewyork

If you’ve been through multiple IVF cycles without answers—or you’re over 40 and feeling dismissed—this episode is for you.

In this candid conversation with Prima Pharmacy, Dr. Norbert Gleicher, Medical Director at the Center for Human Reproduction (CHR), breaks down what really matters in later-in-life fertility care. From the role of immune health and egg quality to anti-inflammatory diets and the truth about “unexplained infertility,” he shares the insights that have helped thousands of patients—especially those over 40—find success where others gave up.

Learn why nutrition matters months before your next cycle, how inflammation can impact implantation, and why CHR’s approach is different from 99% of fertility clinics.

Brought to you by the Center for Human Reproduction (CHR) & Prima Pharmacy. With over 40 years of experience and a history of innovation, CHR has been at the forefront of fertility care since the beginning. 

Our founder, Dr. Norbert Gleicher, reported the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes. At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

Website: www.thechr.com 

Facebook: https://www.facebook.com/chrnewyork 

Instagram: https://www.instagram.com/chrnewyork/ 

Linkedin:  https://www.linkedin.com/company/centerforhumanreproduction/ 

Pinterest: https://www.pinterest.com/CenterforHumanReproduction/ 

TikTok: https://www.tiktok.com/@chrnewyork

Prima Pharmacy: https://www.forprima.com/  

In this empowering episode of The Egg Factor, CHR's Dr. Norbert Gleicher and Dr. David Barad discuss why fertility care for women over 40 demands a completely different approach—and how CHR is leading the way. With a mean patient age of 44, CHR has the oldest IVF patient population of any clinic in the U.S., and possibly the world.

The doctors share what makes these patients—and their care—so unique, the protocols that have helped many achieve success after being told it was too late, and why age should never be the sole barrier to motherhood. Whether you're 35 or 45+, this episode is a must-listen for anyone who refuses to be defined by a number.

Brought to you by the Center for Human Reproduction (CHR) on the Upper East Side of New York City. With over 40 years of experience and a history of innovation, CHR has been at the forefront of fertility care since the beginning. 

Our founder, Dr. Norbert Gleicher, reported the first successful transvaginal egg retrieval in human history, helping to shape the future of IVF as we know it today. CHR is known for tackling some of the most challenging fertility cases—especially women over 40 and those with diminished ovarian reserve—by offering highly individualized, evidence-based care when others often turn patients away.

Our team has published more than 450 peer-reviewed research papers advancing reproductive medicine, reflecting our deep commitment not only to patient care but to the science that drives better outcomes. At CHR, you're never just a number. You're part of a community focused on giving you the personalized support, science, and hope you deserve.

Website: www.thechr.com 

Facebook: https://www.facebook.com/chrnewyork 

Instagram: https://www.instagram.com/chrnewyork/ 

Linkedin:  https://www.linkedin.com/company/centerforhumanreproduction/ 

Pinterest: https://www.pinterest.com/CenterforHumanReproduction/ 

TikTok: https://www.tiktok.com/@chrnewyork