In this episode of the Dementia Researcher Podcast, guest host Dr Fiona McLean is joined by Dr Josh Harvey (University of Exeter), Dr Sarah Marzi (King’s College London), Dr Alexi Nott (Imperial College London), and Dr Sam Washer (Wellcome Trust Sanger Institute) to discuss the role of epigenetics in Alzheimer’s and dementia research.

The episode offers a broad exploration of epigenetics in neurodegenerative diseases, highlighting how gene regulation beyond DNA sequences is advancing our understanding of Alzheimer’s and related conditions. It covers the impact of environmental and lifestyle factors on disease development, as well as emerging research techniques and technologies that could inform future diagnostic and therapeutic approaches.

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Key Topics:

• The fundamentals of epigenetics and its distinction from traditional genetics.

• How epigenetic research is shaping our understanding of Alzheimer's disease.

• The role of environmental factors in influencing epigenetic changes.

• New technologies and their application in epigenetic studies.

• The potential for epigenetics in developing future diagnostics and therapies for neurodegenerative diseases.

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Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk

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This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

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