What if we could treat depression, anxiety, or chronic pain by tuning the brain, just as precisely as a pacemaker regulates the heart?

Jacques Carolan, Program Director at the UK’s ARIA (Advanced Research and Invention Agency), joins us to talk about the next wave of precision neurotechnology; new tools that let us see and influence brain activity with far greater accuracy. We explore how ultrasound might gently stimulate mood circuits without surgery, how gene therapies could switch off seizures before they start, and how “living electrodes” could one day repair damaged brain tissue.

Jacques also explains ARIA’s bold approach to funding high-risk science, what he’s learned from patient engagement, and why he believes the next decade will transform how we understand and care for the brain.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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What if chronic diseases, from Alzheimer’s to autoimmune conditions, share a hidden cause: lingering infections deep within our tissues?

Microbiologist Amy Proal, co-founder of the PolyBio Research Foundation, joins host Allison Duettmann to discuss how persistent pathogens could drive inflammation, aging, and many chronic illnesses, and why our current “autoimmunity” model might be missing the root cause.

They explore PolyBio’s groundbreaking work collecting rarely studied tissue samples, the link between viruses and Alzheimer’s, the rise of long COVID, and simple tools, like clean indoor air, that could prevent future pandemics. Amy also outlines an optimistic vision: strengthening, not suppressing, the immune system to build a healthier, more resilient civilization.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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In this episode, Ken Liu joins the podcast to explore how science fiction serves as our modern mythology. We discuss his new techno-thriller "All That We See or Seem", the concept of egolets (AI capturing facets of our identity), the noematograph (AI as a camera for thought), and the role of collective dreaming in making us more human.

Ken also reflects on Frankenstein, Philip K. Dick, the challenge of translation, and why technology is “the mind made tangible.”

Ken's new book is now available to buy: https://www.amazon.com/All-That-Seem-Julia-Novel/dp/1668083175/ref=sr_1_1?crid=YQBXYV3NPYRQ&dib=eyJ2IjoiMSJ9.qZEp-FJsQjZ1DeI_1aU9dUCHVQLskKq0l80APpXt8lY._8ZY1FJprDwz6sXFyMqa538OZaQZx-_KzsBkHjRww1g&dib_tag=se&keywords=ken+liu+all+that+we+see+or+seem&qid=1758810447&sprefix=ken+liu+all%2Caps%2C326&sr=8-1

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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In this episode of the Existential Hope Podcast, Beatrice Erkers is joined by David Duvenaud, Associate Professor at the University of Toronto and former researcher at Anthropic.

We discuss David’s work on post-AGI civilizational equilibria and the widely discussed paper Gradual Disempowerment. David reflects on why liberalism may not hold up in a world where humans are no longer needed, how UBI could be Goodharted into absurdity, and what it would take to design institutions that protect humans even when incentives don’t.

We also cover:

- Forecasting the long-term future using LLMs trained on historical data

- Robin Hanson’s idea of futarchy (governance by prediction markets)

- Asymmetrical but beneficial relationships between humans and AI

- Uploading, cultural legacies, and the possibility of “worthy successors”

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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What does a genuinely positive future with AI look like? While dystopian visions are common, the most valuable—and scarcest—resource we have is a concrete, hopeful vision for where we're headed.In this episode, we're joined by Nathan Labenz, host of the popular Cognitive Revolution podcast, to explore the tangible possibilities of a beneficial AI-driven world.

Nathan shares his insights on everything from the near-term transformations in education and healthcare—like AI-driven antibiotic discovery and personalized learning—to the grand, long-term visions of curing all diseases and becoming a multi-planetary species.

We dive deep into crucial concepts like Eric Drexler's "comprehensive AI services" as a model for safety through narrowness, the transformative power of self-driving cars, and how we can collectively raise our ambitions to build the future we actually want.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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For years, the conversation about the long-term future has been dominated by a crucial question: how do we avoid extinction? But what if ensuring our survival is only half the battle? In this episode, Beatrice is joined by Fin Moorhouse, a researcher at Forethought and co-author with Will MacAskill of the Better Futures series, to make the case for focusing on the other half: flourishing. Or as we'd like to say in this podcast: Existential Hope!

Fin challenges the idea that a great future will emerge automatically if we just avoid the worst-case scenarios. Using the analogy of a grand sailing expedition, he explores the complexities of navigating towards a truly optimal world, questioning whether our current moral compass is enough to guide us.

The conversation dives into the concept of "moral catastrophes"—profound ethical failings, like industrial animal farming, that could persist even in technologically advanced futures. Fin also tackles the complex challenges posed by digital minds, from the risk of accidental suffering to the creation of "willing servants." He argues for the power of "moral trade" as a tool to build a more pluralistic and prosperous world, and explains why we should aim for a "Viatopia"—a stable and self-sustaining state that makes a great future highly likely.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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Is code just a technical skill for engineers, or is it a deeply humanistic art form capable of expanding our minds? In this episode, host Beatrice Erkers is joined by scientist, author, and Coder-in-Residence at Lux Capital, Sam Arbsman, to explore the profound ideas in his new book, The Magic of Code.

Sam reframes our relationship with computing, arguing that code is one of history's most powerful "tools for thought," standing alongside the alphabet and paper in its ability to augment human intellect. He delves into the fascinating history of this idea, from Don Swanson's concept of "undiscovered public knowledge" in scientific literature to the modern potential of AI to connect disparate ideas and accelerate discovery.

The conversation also explores the democratization of creation through "vibe coding," the power of thinking of an app as a "home-cooked meal," and the critical importance of humility as our technological systems become too complex for any single person to fully understand—a theme from his previous book, Overcomplicated. Sam connects these ideas to the ever-changing nature of knowledge itself, drawing from his first book, The Half-Life of Facts.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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The tech industry we read about every day accounts for only 2% of the global economy. So what about the other 98%? In this episode, host Beatrice Erkers talks to hacker, inventor, and author Pablos Holman about his new book, Deep Future, and why it’s time to look beyond software to solve the world’s biggest problems.

Pablos argues that for decades, our brightest minds have been focused on apps and ads while ignoring the fundamental industries that civilization depends on: energy, manufacturing, shipping, and food. He makes the case for "deep tech"—everything but software—and explains why now is the perfect moment to deploy our "software toolkit" to reinvent these stagnant, trillion-dollar sectors.

From computer-controlled sailing ships and factory-built nuclear reactors buried a mile underground, to the simple genius of a better milk jug that can double a farmer's income, Pablos shares mind-bending examples of technology that truly matters. He also offers a grounded take on AI, explaining why computational modeling for disease control is more impactful than AGI hype, and delivers a powerful vision for a future where energy abundance ends global conflict and automation frees humanity to focus on what makes us thrive: care, community, and connection.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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What if we could build an AI that doesn't just answer questions, but makes fundamental scientific discoveries on its own? That's the mission of Future House, and in this episode, host Allison Duettmann sits down with its co-founder, Andrew White.

Andrew shares the incredible journey that led him from chemical engineering to the forefront of the AI for Science revolution. He gives us a look under the hood at Future House's flock of specialized AI agents, like Crow, Finch, and Owl, and reveals how they recently accomplished in just three weeks what could have taken years: identifying an existing drug as a potential new treatment for a common cause of blindness.

But the conversation doesn't stop at the successes. Andrew offers a sharp critique of the current methods for evaluating AI, explaining what’s wrong with benchmarks like "Humanity's Last Exam" and why the ultimate test is real-world discovery. He also makes a compelling case for completely reinventing the slow and inefficient scientific publishing system for an era where machines are both the producers and consumers of research.

Andrew is also fundraising for the Frontiers Society at IPAM to advance this work. If you’d like to support, you can donate here: IPAM Donation Page.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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As AI systems become more capable and autonomous, staying in control of what they do is increasingly difficult. But the AI we need to solve problems like cancer doesn't have to be one we can no longer steer.

In this episode, we talk with Anthony Aguirre, cosmologist and co-founder of the Future of Life Institute, about how we can design AI to amplify human capability rather than substitute for it.

We cover:

• The economic driver Anthony sees behind AGI: largely not scientific breakthroughs, but capturing a share of the global labor market
• What "Tool AI" means to Anthony as an alternative to AGI, and why he thinks it can deliver most of what we want without replacing people
• Whether Tool AI is stable: the tension between staying in control of AI and the ease of completing tasks
• How legal liability for AI agents could quietly steer the industry toward more controllable systems
• Two concrete ideas for transformative AI tools we could build today to improve democracy and the information landscape

This episode is part of our AI Pathways series, where we explore the choices we can still make about how AI gets built.

Chapters:

0:00 Cold open

0:43 Why we should build detailed scenarios of alternative AI futures

4:42 Turning abstract AI philosophies into concrete futures: the value of scenario building

6:42 AI as a tool vs. AI as a replacement: the case for keeping humans in control

13:27 Is Tool AI a stable long-term path, or will it drift toward AGI?

16:03 Why the AI industry is heading towards replacing humans, and how to shift that

23:41 What should AI replace, and what should stay human?

29:20 How AI liability law could force a shift toward safer, controllable systems

35:16 Tool AI vs. comprehensive AI services: two visions for a safer AI future

39:50 Two AI tools we could build today: large-scale deliberation and the epistemic stack

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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Hosted on Acast. See acast.com/privacy for more information.