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Fewer cases of melanoma among people taking vitamin D supplements

University of Eastern Finland, January 10, 2023

Fewer cases of melanoma were observed among regular users of vitamin D supplements than among non-users, a new study finds. People taking vitamin D supplements regularly also had a considerably lower risk of skin cancer, according to estimates by experienced dermatologists. The study, conducted in collaboration between the University of Eastern Finland and Kuopio University Hospital and published in Melanoma Research, included nearly 500 people with an increased risk of skin cancer. 498 adult patients estimated to have an increased risk of a skin cancer, such as basal cell carcinoma, squamous cell carcinoma or melanoma, were recruited at the dermatological outpatient clinic of Kuopio University Hospital. Experienced dermatologists at the University of Eastern Finland carefully analysed the patients’ background information and medical history and examined their skin. The dermatologists also classified the patients into different skin cancer risk classes, namely low risk, moderate risk and high risk. Based on their use of oral vitamin D supplements, the patients were divided into three groups: non-users, occasional users and regular users. Serum calcidiol levels were analysed in half of the patients and found to correspond to their self-reported use of vitamin D.A key finding of the study is that there were considerably fewer cases of melanoma among regular users of vitamin D than among non-users, and that the skin cancer risk classification of regular users was considerably better than non-users’. Logistic regression analysis showed that the risk for melanoma among regular users was considerably reduced, more than halved, compared to non-users.The findings suggest that even occasional users of vitamin D may have a lower risk for melanoma than non-users. Other relatively recent studies, too, have provided evidence of the benefits of vitamin D in melanoma, such as of the association of vitamin D with a less aggressive melanoma.

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Diabetics should pay attention to vitamin C

University of Otago (New Zealand), January 9 2023.

Research reported in Nutrients suggests that low intake and serum levels of vitamin C may be particularly risky for adults with diabetes. The study analyzed data from 25,206 men and 26,944 women who participated in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. Four hundred twenty-eight individuals had type 1 diabetes and 6,807 had type 2 diabetes. At the beginning of the study, 38% of the people had an intake of vitamin C that was below the estimated average requirement (EAR), which worsened to 46.5% by 2017-2018. Individuals whose intake of vitamin C was lower than the EAR had a 20% higher risk of type 2 diabetes compared with an intake above the EAR, and those who did not use vitamin C supplements had a 28% greater risk than vitamin C supplement users. Low and deficient serum vitamin C levels were associated with fewer years of life in comparison with normal vitamin levels. Compared with an adequate intake of vitamin C, the risk of mortality through 2019 among type 2 diabetics was 25% greater for those with a very low intake of the vitamin. Deficient serum levels of the vitamin were associated with an 84% greater mortality risk compared with adequate levels. Not supplementing with vitamin C was associated with a 25% greater mortality risk among people with type 1 diabetes, a 20% greater risk among those with type 2 diabetes and a 24% greater risk among nondiabetics compared with supplementation. “Observation of declining vitamin C intake and deleterious consequences of low serum vitamin C in US adults with diabetes suggests encouragement of vitamin C intake, including vitamin C supplementation of 500–1000 mg/day, may be beneficial for