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Component of citrus fruits found to block the formation of kidney cysts

University of London and Kingston University, UK October 3, 2022

A study published in British Journal of Pharmacology has identified that a component of grapefruit and other citrus fruits, naringenin, successfully blocks the formation of kidney cysts.

Known as polycystic kidney disease, this is an inherited disorder which leads to the loss of kidney function, high blood pressure and the need for dialysis. Few treatment options are currently available.

The team of scientists from University of London and Kingston University London used a simple, single-celled amoeba to identify that naringenin regulates the PKD2 protein responsible for polycystic kidney disease and as a result, blocks formation of cysts.

To test how this discovery could apply in treatments, the team used a mammalian kidney cell-line, and triggered the formation of cysts in these cells. They were then able to block the formation of the cysts by adding naringenin and saw that when levels of the PKD2 protein were reduced in the kidney cells, so was the block in cyst formation, confirming that the effect was connected.

“Indeed, this study provides a good example of how chemicals identified in plants can help us develop new drugs for the treatment of disease,” added Professor Debbie Baines from St George’s, University of London.

Medical cannabis treats cancer and boosts the immune system, say scientists after reviewing more than 100 studiesRostock University Medical Center (Germany), October 1, 2022

A review of over 100 studies has shown that cannabis really is medicinal. Indeed, scientific analysis has shown that the cannabinoid compounds found in marijuana can stop cancer cells from dividing and spreading — and can even cut off blood supply to tumors. The researchers say that their findings prove that cannabis can be used as a cancer treatment. Does that mean plants will finally start getting recognized for their medicinal powers? One can only hope.

A team of German researchers, led by Professor Burkhard Hinz, have concluded that cannabis compounds can fight cancer. The scientists, say that an array of cannabinoids have medicinal value.

Professor Hinz and his team have shown that over 100 different studies have indicated cannabis has the ability to treat cancer.

“In this context accumulating data from preclinical models suggest that cannabinoids elicit anti-cancer effects on several levels of cancer progression,” Hinz explained.

“Clinical studies are now urgently needed to investigate the impact of cannabinoids on cancer growth and progression in patients,” he added.

Older adults living unhealthy lifestyles twice as likely to end up in a nursing homeOlder adults who lead an unhealthy lifestyle are twice as likely to end up needing a nursing home in comparison to their more active peers, a new study reveals.

Researchers at the University of Sydney found smoking, physical activity, sitting, and sleep quality to have a strong link to nursing home admission rates. Surprisingly, diet quality did not display the same connection.

Smokers were 55 percent more likely than non-smokers to end up needing nursing care. For the study, which is the first of its kind, researchers looked at data on more than 127,000 Australians who took part in a large study on healthy aging between 2006 and 2009. Study authors followed up with these patients for 11 years on average.

The team divided them into the three risk groups based on five lifestyle factors: smoking, physical activity, sitting, sleep quality, and diet quality.

One quarter of participants (24%) ended up in the lowest ri