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Polyphenol consumption in adolescents is associated with better cardiovascular healthUniversity of Barcelona (Spain), October 24, 2022

The consumption of polyphenols in adolescents is associated with a better cardiovascular health, according to a collaborative research study which includes the University of Barcelona.

The study has been published in Scientific Reports. As part of the study, the researchers analyzed the amount of polyphenols in the urine of 1,326 adolescents that took part in the SI! Program (Integral Health) of 24 secondary education schools in Madrid and Barcelona.

Polyphenols are bioactive compounds with antioxidant and anti-inflammatory properties found in several plant-based foods, mainly in fruit, vegetables, nuts and olive oil. To date, there were few studies on the intake of polyphenols in children and adolescents.

“With the results of this study, we observed that a higher urinary polyphenol excretion is linearly associated with a higher cardiovascular health index in adolescents aged 11-14, specially in children. This cardiovascular health index is defined by the criteria established by the American Heart Association (AHA), which considers seven variables: body mass index, physical activity, smoking, diet, blood pressure, total cholesterol and blood glucose,” says Professor Rosa M Lamuela, director of the Institute for Research in Nutrition and Food Safety of the University of Barcelona

NAC supplements may benefit cardiovascular health: Human dataUniversity of Marburg (Germany), October 16, 2022Four weeks of supplementation with N-acetylcysteine (NAC) may reduce levels of homocysteine and improve blood pressure, says a new analysis of two randomized, double-blind, placebo-controlled trials.

A daily dose of 1.8 grams of NAC could lower homocysteine levels by about 12%, and may improve systolic and diastolic blood pressure, according to findings published in the American Journal of Clinical Nutrition .

Elevated levels of the amino acid homocysteine have been reported to increase the risk of cardiovascular disease. This has led some to point to the potential of the B-vitamins to reduce homocysteine levels and reduce the risk of CVD. B vitamins are cofactors for enzymes involved in homocysteine metabolism and therefore giving people vitamin B supplements is hypothesized to reduce homocysteine levels and therefore reduce cognitive impairment.

However, clinical trials including participants at risk of, or already suffering from, cardiovascular disease have produced null results, with some experts arguing that short term B vitamin supplementation should not be expected to reverse the long-term development of heart disease.

“Because recent analyses that controlled for confounders such as statins or folate fortification detected a benefit of folate/B-vitamins for stroke (22–24), homocysteine may conditionally be a therapeutic target,” wrote the authors of the new study, led by Prof Wulf Hildebrandt, formerly with the German Cancer Research Center and now at the University of Marburg (Germany).

“Therefore, an alternative agent for (more) effective homocysteine lowering may be desirable, especially for conditions in which B-vitamins are ineffective [e.g., in renal disease] or if a reduction in homocysteine of >25% is intended.”

There is a known link between homocysteine and NAC, and some studies have shown that NAC may reduce levels of the amino acid, but the data is somewhat mixed.

Results showed that NAC supplementation significant decreased homocysteine levels by an average of 11.7% (