Dan Shipper is the co-founder and CEO of Every, a media company built around writing, software, and AI. With a tiny team, they put out a daily newsletter, build products, and run a consulting arm, all while staying weird and experimental. Dan’s one of the most thoughtful writers on how AI is reshaping creativity, business, and what it means to build.

Alex Konrad is the founder of Upstarts, a newsletter about the next breakout companies before they break out. He spent over a decade at Forbes, where he wrote 15+ cover stories, co-created the Cloud 100 list, and led Midas List coverage of the top VCs in the world.

Together, they discuss and debate building sustainable media businesses today, using AI to amplify creativity, and why legacy playbooks no longer apply.

In this conversation, you’ll learn:
1. Why being weird is often a competitive advantage
2. How thinking like a product person (and not just a writer) shapes everything they publish
3. The surprisingly tactical ways they protect time for original thinking
4. Why Upstarts and Every both resisted the pressure to “build the platform” too soon
5. How Every runs multiple AI products and a daily newsletter with only 15 people
6. Why they both believe your business model is a creative decision
7. Their thinking around independent journalism as a “tech-enabled service,” not content
8. How AI tools like Claude, Cora, and ChatGPT actually fit into their creative process
9. How to avoid burnout when your business is also your identity
10. How to stay joyful and experimental when everyone else is optimizing

Where to find Dan:
Newsletter: every.to
X: @danshipper

Where to find Alex:
Newsletter: https://www.upstartsmedia.com
X: @alexrkonrad

Where to find TheGP:
Newsletter:  https://thegeneralpartnership.substack.com/
X: @thegp

Referenced in this episode:

• MrBeast: https://www.youtube.com/@MrBeast
• The Pragmatic Engineer: https://www.pragmaticengineer.com
• Stratechery by Ben Thompson: https://stratechery.com/
• Lenny’s Newsletter: https://www.lennysnewsletter.com/
• Tom Brady quote: “Winners focus on winning. Losers focus on winners.”
• Acquired Podcast: https://www.acquired.fm/
• Claude: https://claude.ai
• ChatGPT: https://chatgpt.com 
• War and Peace by Leo Tolstoy
• The writer Maggie Nelson
• Spiral by Every: https://spiral.computer
• Cora by Every: https://cora.computer
• Think Week (Bill Gates’s famous retreat)
• Documentary: WeWork: Or the Making and Breaking of a $47 Billion Unicorn 

Christina Farr, longtime healthtech journalist and now advisor, investor, and editor-in-chief of Second Opinion Media, sits down with Siddhartha Mukherjee, Pulitzer Prize–winning author of "The Emperor of All Maladies," oncologist, and founder of Manas AI.

In this expansive conversation, they explore the current and future role of AI in medicine. Sid offers a typology for how LLMs are showing up in clinical practice and scientific discovery, while Chrissy pushes on what AI can’t yet replicate: intuition, empathy and institutional memory. They discuss whether AI will replace the “intelligentsia,” what it gets right and wrong about diagnostics and drug discovery, and how clinicians can stay relevant by staying creative. This is a thoughtful, urgent discussion between two people who are both deeply familiar with the systems of medicine.

In this conversation, you’ll learn:
1. A six-part framework for how AI is transforming healthcare and science
2. How ambient scribes, LLMs, and generative chemistry are reshaping workflows
3. The difference between simulated empathy and real human care
4. What LLMs still miss: texture, taste, and tacit knowledge
5. How AI might (or might not) generate revolutionary scientific insights
6. Why the future belongs to clinicians who generate new knowledge, not just apply it

Where to find Chrissy:
LinkedIn: https://www.linkedin.com/in/christinafarr/
X: https://x.com/chrissyfar
Substack: https://secondopinion.media/

Where to find Sid:
LinkedIn: https://www.linkedin.com/in/siddhartha-mukherjee-19b6b8126/
The New Yorker: https://www.newyorker.com/contributors/siddhartha-mukherjee
Books: The Emperor of All Maladies, The Gene, The Song of the Cell

Where to find TheGP: 

• LinkedIn: https://www.linkedin.com/company/the-general-partnership
• X: https://x.com/thegp
• Substack: https://thegeneralpartnership.substack.com/

Referenced in this episode:
• Manas AI: https://www.manasai.co
• Richard Feynman’s “Cargo Cult Science” lecture: https://calteches.library.caltech.edu/51/2/CargoCult.htm
• Thomas Kuhn’s The Structure of Scientific Revolutions: https://www.amazon.com/Structure-Scientific-Revolutions-50th-Anniversary-ebook/dp/B007USH7J2/
• Karl Popper’s theory of falsifiability: https://www.simplypsychology.org/karl-popper.html
• Stephen Jay Gould’s “The Median Isn’t the Message”: https://journalofethics.ama-assn.org/article/median-isnt-message/2013-01
• David Fajgenbaum’s Chasing My Cure: https://chasingmycure.com/

Katie Dill, Head of Design at Stripe, and Randy Hunt, Head of Design at Notion, sit down to swap stories in the first episode of The General Podcast. This is a conversation between two of the most thoughtful design leaders in tech, covering everything from building taste into products to maintaining creative conviction inside fast-scaling orgs. They discuss how to protect what makes design great, what designers uniquely bring to the table in the age of AI, and why sometimes you just have to pick mint chip and go.

In this conversation, you’ll learn:

1. Why beautiful, well-crafted products matter - especially in the age of AI
2. The case for “fewer memos, more demos” and how Stripe operationalizes quality
3. How Notion fosters taste through founder collaboration and radical transparency
4. A dead-simple metaphor for decision-making: picking one flavor of ice cream
5. The enduring value of the auteur in design and how to scale conviction
6. Why prototyping trumps PowerPoints
7. How both teams use design rituals to stay connected

Where to find Katie: 

• LinkedIn: https://www.linkedin.com/in/katie-dill-79168b3
• X: https://x.com/lil_dill

Where to find Randy: 

• LinkedIn: https://www.linkedin.com/in/randyjhunt/
• X: https://x.com/randyjhunt

Where to find TheGP: 

• LinkedIn: https://www.linkedin.com/company/the-general-partnership
• X: https://x.com/thegp
• Substack: https://thegeneralpartnership.substack.com/

What is The General Podcast?