In this episode, Dr. C tries to explain the complexity of the human genome. Problem is, nobody understands it because it is too complex! He compares the genome to a computer operating system, but this quickly gets eclipsed by what he calls the four-dimensional genome.

Show notes

Location: Mid-America Windmill Museum

Links and sources:

The Four-Dimensional Genome

The High-Tech Cell

Bolzer A, et al., Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes, PLoS Biol 3(5):e157, 2005.

Duncan AW, et al., The ploidy conveyor of mature hepatocytes as a source of genetic variation, Nature 467:707-710, 2010.

Baillie JK, et al., Somatic retrotransposition alters the genetic landscape of the human brain, Nature 479:534-537, 2011.

Xue S, Barna M, Specialized ribosomes: a new frontier in gene regulation and organismal biology, Nature Reviews Molecular Cell Biology 13:355–369, 2012.

Intro Music by Xihcsr