The Hormone Shift Show™ Podcast

By Leslie Duffy, RN

If you’re a woman in your 40s or 50s, wondering what fresh hell this is, you’re in the right place.

Welcome to The Hormone Shift Show™ Podcast, a podcast about “the shift,” for women in the shift.

H... more

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FAQs about The Hormone Shift Show™ Podcast:

How many episodes does The Hormone Shift Show™ Podcast have?

The podcast currently has 6 episodes available.

The Hormone Shift Show™ Podcast episodes:

September 04, 2025 5: 10 Things Women Over 40 Need to Know About Estrogen
“Estrogen decline in perimenopause is not steady. It’s a rollercoaster.” – Leslie Duffy
Do you feel like your body changed overnight? Maybe your weight won’t budge, your joints ache, your period is all over the place, or your moods swing like a rollercoaster? Chances are, estrogen is connected to your symptoms.
Most of us were never taught about what estrogen does in our bodies, and by the time we walk into our doctor’s office, it’s already causing chaos. Then, their jargon can leave you feeling lost, dismissed, or even foolish for not knowing what’s going on with your own body.
Today, I’m breaking down 10 things every woman over 40 needs to know about estrogen and, more importantly, what to do about it. You’ll learn what estrogen dominance is, how estrogen and progesterone work like a seesaw, why high stress makes estrogen dominance worse, and how estrogen works as your “juicy hormone” to keep your skin plump, your joints flexible, and your vaginal tissue healthy. We’re also digging into how estrogen affects your bones, metabolism, histamine response, and more, plus the steps you can take right now to start to optimize your hormone health.
By the end of this episode, you’ll be aware of red flags that may signal estrogen imbalance, which action steps to prioritize, and why estrogen matters for more than your cycle. It’s time to stop guessing, start tracking, and feel empowered in this season of life.
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Your Takeaways
The three types of estrogen and how they shift through our life stages
Why estrogen is the “juicy hormone” for skin, joints, and vaginal health
How estrogen supports collagen, bone strength, and flexibility
The rollercoaster nature of estrogen in perimenopause
Why estrogen detox is crucial

Check out the full show notes at https://leslieduffycoaching.com/5.

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Free Resources
Fireproof Your Hormones: A real-life approach to calming inflammation and supporting hormone health. Get Your Free Guide at https://stan.store/leslieduffycoaching/p/fireproof-your-hormones
Tracker + Symptom Checklist: Too many symptoms, not enough answers? Grab this free tracker + symptom checklist to start connecting the dots at https://idyllic-wind-45449.myflodesk.com/lj57cu63zk

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Articles
Effect of estrogens on skin aging and the potential role of SERMs https://pmc.ncbi.nlm.nih.gov/articles/PMC2685269
Estrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts https://pmc.ncbi.nlm.nih.gov/articles/PMC2685269
Phytoestrogens protect joints in collagen induced arthritis by increasing IgG glycosylation and reducing osteoclast activation https://www.sciencedirect.com/science/article/abs/pii/S1567576919328826

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Connect with Leslie
Connect with me and learn more at LeslieDuffyCoaching.com (https://leslieduffycoaching.com/)
Send me a message and follow me on Instagram @LeslieDuffyCoaching (https://www.instagram.com/leslieduffycoaching/)
Watch the video version of this episode on YouTube @TheHormoneShiftShow (https://www.youtube.com/@TheHormoneShiftShow)
I love hearing from listeners! Email your questions or topic requests to [email protected]
Check out Leslie’s favorite things: Amazon Storefront (https://www.amazon.com/shop/leslieduffycoaching)
...more
27min
August 28, 2025 4: How to Rewire Your Money Story in Midlife with Jeannie Dougherty
“Your money story is just that: a story. And you get to rewrite it.” - Jeannie Dougherty

If you’ve ever felt guilty about money, avoided checking your bank account, or wondered why you’re hustling so hard but never feel secure, you’re not alone. In midlife, financial stress doesn’t just live in your bank account; it lives in your body. It keeps you up at night, spikes your cortisol, fuels anxiety, and leaves you running on fumes no matter how hard you push.
In this episode, I sit down with bestselling author and certified money coach Jeannie Dougherty to unpack how your money story was formed and how to let it go in midlife. We talk about the hidden connections between money and health, why forgiveness (including forgiving yourself) is a key part of financial healing, and how to start rewiring your “money brain” so you can break free from old patterns.
Jeannie shares practical ways to uncover your money values, spot red flags in relationships, and shift from scarcity and shame into empowerment and alignment. If you’ve been white-knuckling your finances, manifesting without results, or constantly feeling blocked when it comes to money, this conversation will help you release the guilt, take back your power, and start creating financial and physical freedom.
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Your Takeaways
How family money stories shape your financial mindset
Why forgiveness of others and yourself is key to releasing financial shame
The difference between money mindset and rewiring your brain around money
What your spending patterns reveal about your core values
How health investments today create long-term freedom later
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Links & Resources
Check out the full show notes at https://leslieduffycoaching.com/how-to-rewire-your-money-story-in-midlife-with-jeannie-dougherty/
Book a Wellness Shift Strategy Call with Leslie - Your first step toward feeling clear, capable, and in control of your health again (https://calendly.com/leslieduffycoaching/wellness-shift-strategy-call)
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Connect with Leslie
Connect with me and learn more at LeslieDuffyCoaching.com (https://leslieduffycoaching.com/)
Send me a message and follow me on Instagram @LeslieDuffyCoaching (https://www.instagram.com/leslieduffycoaching/)
Watch the video version of this episode on YouTube @TheHormoneShiftShow (https://www.youtube.com/@TheHormoneShiftShow)
I love hearing from listeners! Email your questions or topic requests to [email protected]
Check out Leslie’s favorite things: Amazon Storefront (https://www.amazon.com/shop/leslieduffycoaching)
...more
58min
August 20, 2025 3: Why You're Anxious AF: How Hormone Shifts Can Hijack Your Calm in Perimenopause
“Anxiety in perimenopause isn’t about your husband or your job; it’s your hormones.” - Leslie Duffy
While it would be easy to think your increased anxiety or irritability is a result of your workload, your partner, or the state of the world, that might not be the case. Here’s the truth: in perimenopause, shifting estrogen and progesterone is remodeling your brain and making you more vulnerable to anxiety than ever before. Racing thoughts, poor sleep, heart palpitations, jaw tension, or even not wanting to spend time doing things you used to love can all be signs that your hormones, not your willpower, are causing a change.
Understanding the “why” behind your anxiety is the first step toward taking back your power. In this episode, I’m connecting the dots between what’s happening in your brain and what you’re feeling day to day. We’ll unpack how shifting estrogen and progesterone levels change your stress response, why your nervous system suddenly feels more sensitive, and the real reason your body is reacting like there’s danger even when you’re safe.
I’m sharing lifestyle interventions that actually work, the pivotal roles of sleep, nutrition, and movement, and when it might make sense to go deeper with functional testing for hormones, gut health, thyroid, or adrenals. You’ll leave this episode knowing that you’re not broken or crazy, and you can regain a sense of calm and control, even in the middle of the hormone shift.
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Your Takeaways
Why your anxiety might not be about your job or your partner
How fluctuating estrogen and progesterone disrupt calm and focus
Why anxiety feels bigger during midlife
Everyday practices that ease anxious symptoms
Tracking cycles, symptoms, and labs to bring clarity and control

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Links & Resources
FREE Tracker: Feeling Anxious AF? Grab this free tracker + symptom checklist to start connecting the dots.(https://idyllic-wind-45449.myflodesk.com/lj57cu63zk)
HeartMath (https://www.heartmath.com/)
Book a Wellness Shift Strategy Call with Leslie - Your first step toward feeling clear, capable, and in control of your health again (https://calendly.com/leslieduffycoaching/wellness-shift-strategy-call)

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Connect with Leslie
Connect with me and learn more at LeslieDuffyCoaching.com (https://leslieduffycoaching.com/)
Send me a message and follow me on Instagram @LeslieDuffyCoaching (https://www.instagram.com/leslieduffycoaching/)
Watch the video version of this episode on YouTube @TheHormoneShiftShow (https://www.youtube.com/@TheHormoneShiftShow)
I love hearing from listeners! Email your questions or topic requests to [email protected]
Check out Leslie’s favorite things: Amazon Storefront (https://www.amazon.com/shop/leslieduffycoaching)
...more
26min
August 13, 2025 2: How to Treat Yo'self Without Food
“Stress is the enemy of self-control, and your cravings are not about willpower.” – Leslie Duffy
If you’ve ever found yourself halfway through a bag of chips or surrounded by Oreo crumbs, wondering what just happened, you’re not alone. Your cravings aren’t a sign of low willpower or weakness; they’re driven by shifts in estrogen and dopamine, and amplified during perimenopause and menopause. That “treat yourself” moment of comfort is actually one of the ways your body is trying to self-regulate.
In this episode, I’m breaking down why your cravings feel so hard to resist and how you can take back control without relying on willpower or giving up the foods you love forever. We’ll talk about the dopamine–estrogen connection, the cues that trigger cravings, and how low dopamine can push you toward food, wine, shopping, or scrolling for that quick hit of feel-good. You’ll also learn how stress magnifies cravings, what emotions often hide underneath them, and how to start catching yourself in the moment so you can choose differently.
I’ll share my strategy for creating a plan to calm cravings, replace them with healthier dopamine boosts, and develop your own “treat yourself” menu that supports your body instead of sabotaging it. You’ll leave this episode with tools you can use today, and the relief of knowing this isn’t about discipline, it’s about working with your brain and hormones to create real change.

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Your Takeaways
How stress and hormones team up to fuel cravings
The cue–reward cycle and how to break it
Why food feels like comfort, connection, and survival
Awareness: your first weapon against cravings
Simple swaps and small wins to rewire your rewards

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Grab Leslie’s Resources
FREE PDF: Natural ways to increase dopamine levels (https://drive.google.com/file/d/1ygZxPSHEVRca7pb37Og8qaaGMR1py7vl/view?usp=sharing)
Mini-Course: CALM the Cravings [Use discount code: HSS15 for 15% off!] (https://stan.store/leslieduffycoaching/p/calm-the-cravings)
Book a Wellness Shift Strategy Call - Your first step toward feeling clear, capable, and in control of your health again (https://calendly.com/leslieduffycoaching/wellness-shift-strategy-call)

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Mentioned in this episode
Estradiol and the reward system in humans (https://www.sciencedirect.com/science/article/abs/pii/S2352154617302735)
Hormone sensitivity predicts the beneficial effects of transdermal estradiol on reward-seeking behaviors in perimenopausal women: A randomized controlled trial (https://pmc.ncbi.nlm.nih.gov/articles/PMC10568486/)

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Connect with Leslie
Connect with me and learn more at LeslieDuffyCoaching.com (https://leslieduffycoaching.com/)
Send me a message and follow me on Instagram @LeslieDuffyCoaching (https://www.instagram.com/leslieduffycoaching/)
Watch the video version of this episode on YouTube @TheHormoneShiftShow (https://www.youtube.com/@TheHormoneShiftShow)
Check out Leslie’s favorite things: Amazon Storefront (https://www.amazon.com/shop/leslieduffycoaching)
...more
27min
August 06, 2025 1: Why You’re Struggling To Lose Weight After 40 and How to Fix It
“You can’t lose weight if your life is a dumpster fire.” – Leslie Duffy

If you’ve been hitting the gym, counting the calories, and still can’t budge the numbers on the scale, here’s the truth: it’s probably not what you’re eating. In midlife, fluctuating estrogen levels make our bodies more sensitive to stress, and we can’t handle the stress response as well as we used to. Your overscheduled life, that coworker you can’t stand, or even the clothes that don’t fit right, can spike your blood sugar just like a candy bar would. The result? Higher cortisol, stubborn belly fat, crappy sleep, and sluggish digestion.
In this episode, I’m pulling back the curtain on how stress messes with your hormones in midlife and creates weight loss resistance, and why pushing yourself harder isn’t the answer. I’m also sharing my four-step CALM method to get out of fight-or-flight, lower cortisol, and put your body back in fat-burning, hormone-balancing mode. It’s time to start working with your body instead of against it.
If you’ve been doing everything right and still feel stuck, this episode will help you to connect the dots and finally break free.
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What You’ll Learn
Why stress is basically a Snickers bar — minus the fun
The three types of stress and how chronic stress affects your weight
How hormones like cortisol drive stress-related weight gain
The CALM Method for regulating your body, not just your habits
Why letting go, slowing down, and shifting your mindset can actually help you lose weight.
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Resources from Leslie
Get your Free Episode 1 Worksheet! (https://drive.google.com/file/d/1Ow6p1S0C8X5fvoJ0q0UUqEAT_HKoGskt/view?usp=drive_link)
Free PDF: The CALM Plate —Get your free printable resource (https://stan.store/leslieduffycoaching/p/the-calm-plate)
Mini-Course: CALM the Cravings [Discount code: HSS15] (https://stan.store/leslieduffycoaching/p/calm-the-cravings)
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Mentioned in this episode
Huberman Lab | Control Stress for Healthy Eating, Metabolism & Aging with Dr. Elissa Epel (https://youtu.be/ulHrUVV3Kq4)
Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation (https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP271539)
Can Meditation Slow Rate of Cellular Aging? Cognitive Stress, Mindfulness, and Telomeres (https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04414.x)
The Chain Mediating Effect of Negative Perfectionism on Procrastination: An Ego Depletion Perspective (https://www.mdpi.com/1660-4601/19/15/9355)
Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1 (https://pmc.ncbi.nlm.nih.gov/articles/PMC6341301/)
Impact of the Baltimore Experience Corps Trial on cortical and hippocampal volumes (https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2014.12.005)
Stress, cortisol, and obesity: a role for cortisol responsiveness in identifying individuals prone to obesity (https://pubmed.ncbi.nlm.nih.gov/27345309/)
Stress May Cause Excess Abdominal Fat In Otherwise Slender Women, Study Conducted At Yale Shows (https://www.sciencedaily.com/releases/2000/11/001120072314.htm)
The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging (https://www.sciencedirect.com/science/article/pii/S1568163720303020)
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Let's Stay Connected
Connect with me and learn more at LeslieDuffyCoaching.com (https://leslieduffycoaching.com/)
Send me a message and follow me on Instagram @LeslieDuffyCoaching (https://www.instagram.com/leslieduffycoaching/)
Watch the video version of this episode on YouTube @TheHormoneShiftShow (https://www.youtube.com/@TheHormoneShiftShow)
Check out Leslie’s favorite things: Amazon Storefront (https://www.amazon.com/shop/leslieduffycoaching)
...more
22min
August 01, 2025 Welcome to The Hormone Shift Show™ Podcast
“Midlife isn’t a crisis, it’s a turning point. Your comeback starts here.” – Leslie Duffy
If you’re a woman over 40 and you barely recognize yourself in the mirror… your energy’s in the tank, your emotions are all over the place, and you’re wondering what happened to the “you” you used to be, you’re not alone. And you’re not broken.
I’m Leslie Duffy, a registered nurse, life coach, and certified functional hormone specialist. After 20+ years of helping women reclaim their health, I created The Hormone Shift Show™ Podcast to give you the answers nobody else is talking about.
This is the strategy podcast for women ready to stop guessing and start feeling like themselves again. Here’s what you won’t get: endless to-do lists, restrictive diets, or morning routines that take 2 hours. Here’s what you will get: science-backed tools you can use right now to balance your hormones, regain your energy, and finally breathe again.
Your 40s and 50s aren’t the beginning of the end; they’re your window of health. What you do today shapes how you age and thrive for decades to come.
So if you’re tired of pushing through and ready to rewrite your next chapter, hit follow now.
Your comeback starts here.
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Connect with me and learn more at LeslieDuffyCoaching.com (https://leslieduffycoaching.com/)
Send me a message and follow me on Instagram @LeslieDuffyCoaching (https://www.instagram.com/leslieduffycoaching/)
Watch the video version of this episode on YouTube @TheHormoneShiftShow (https://www.youtube.com/@TheHormoneShiftShow)
...more
3min

FAQs about The Hormone Shift Show™ Podcast:

How many episodes does The Hormone Shift Show™ Podcast have?

The podcast currently has 6 episodes available.