The Human 5.0 Project

By Ultimate Biohacker 10x

The Human 5.0 Project is the podcast where science meets self-optimization. Hosted by Ultimate Biohacker 10X, this show explores the real research, real data, and real dos

... more

Download on the App Store

Download on the App Store

Get it on Google Play

FAQs about The Human 5.0 Project:

How many episodes does The Human 5.0 Project have?

The podcast currently has 112 episodes available.

The Human 5.0 Project episodes:

February 13, 2026Biohacking Your Diet in 2026: AI + Genomics + Wearables—What Actually Works
Personalized Nutrition 2026: Biohacking With AI, Wearables & DNA (Signal vs Noise):
Unlock the 2026 edge in biohacking and personalized nutrition—without the hype. In this episode, we dive into why one-size-fits-all diets fail, explore metabolic flexibility, gut microbiome, genomics, and brain-body links. Get a no-BS breakdown of tools like CGMs, wearables, AI apps, and peptides, plus controversies around extremes and data overload. End with a free Monday start plan: protocols for stable energy, fat loss, gut health, and more.
Opening: The Edge of Personalized Nutrition
Disclaimer & Mission
Hook: One-Size-Fits-All is Dead
Definitions: Biohacking vs. Personalized Nutrition
Science: Why You Respond Differently
2026 Toolkit: Signal vs. Noise
Biohacker’s Pantry: Food-First Precision
Controversy Corner: Risks & Extremes
Monday Start Plan: Minimum Viable System
Close: Thesis & CTA

Educational only—not medical advice. Tailored for biohackers in hot spots like Fort Lauderdale? Hydration is key! Subscribe for more signal-over-noise health content. What's your top goal? Comment below!

🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.

#PersonalizedNutrition #Biohacking #Nutrition #MetabolicHealth #Longevity #Healthspan
#AI #Wearables #OuraRing #WHOOP #CGM #Glucose #BloodSugar #ContinuousGlucoseMonitor
#Genetics #Nutrigenomics #DNA #Microbiome #GutHealth #Viome #ZOE
#Supplements #Peptides #Nootropics #Sleep #HRV #Recovery #Exercise #WholeFoods
#HealthPodcast #ScienceBased #EvidenceBased #SignalVsNoise #UltimateBiohacker10X
...more
17min
February 12, 2026Brewing Up Brain Health-Can Coffee Prevent Alzheimer's?
Ground Truths: Coffee, Correlation, and the Quest to Prevent Dementia

Dive into the latest JAMA study linking caffeinated coffee and tea to a potential 18% lower dementia risk—but hold the hype! In this 30-minute episode of Ground Truths, we break down the science with a biohacker lens: from the massive 43-year cohort data on over 131,000 people, to the "massive grain of salt" warnings from Dr. Céline Gounder. We explore associations vs. causation, plausible mechanisms like adenosine blocking, and why decaf misses the mark. Plus, actionable takeaways on timing your caffeine, stacking it with proven prevention strategies (exercise, diet, hearing health), and avoiding the sleep paradox.
Is your morning brew a brain booster or just a marker of healthy habits? We zoom out to the boring winners that actually move the needle on dementia risk, affecting over 7 million Americans.
Open: Permission vs. Prevention
The Grain of Salt: Causation Caveats
Study Deep Dive: Design & Results
Mechanisms & Biohacks
Practical Steps & Prevention Stack
Outro: Build a Brain-Friendly Life
Sources: JAMA (2026 study), CBS News (Dr. Gounder), Alzheimer's Association. Educational content; consult a doctor for personal advice.

🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
#CoffeeAndBrainHealth #DementiaPrevention #CaffeineScience #Biohacking #JAMAStudy #AlzheimersRisk #TeaBenefits #EvidenceBasedHealth #PublicHealth #NoHypeScience#TheHuman5.0Project#Ultimatebiohacker10X
...more
12min
February 12, 2026Follistatin 344 Explained: Myostatin Inhibitor for Muscle Growth, Gene Therapy Results & Real Risks (2026 Update)
Myostatin Inhibitor Follistatin-344: Gene Therapy Breakthroughs, Peptide Hype, Side Effects & If It Actually Works

Tired of hitting your genetic muscle ceiling? In this deep dive, we break down Follistatin-344—the "myostatin brake release" everyone's talking about. From animal/primate studies showing massive hypertrophy to human trials in muscular dystrophy, gene therapy (AAV delivery) vs. gray-market peptides, Bryan Johnson/Minicircle experiments, mechanisms (myostatin + activin blockade), realistic gains, side effects (reproductive risks, immune issues, tendon lag), and why most online vials don't match the science.
No hype—just signal on whether this unlocks true muscle growth or stays in the lab.
Intro: The Genetic Ceiling & Myostatin Brake
Why Myostatin Matters (Belgian Blue Proof)
Follistatin Isoforms: FS-344 vs FS-315/288
Mechanism: How It Traps Myostatin & Activins
The Three Paths to Hypertrophy
Animal & Primate Research: Real Gains & Plateaus
Human Trials: Becker MD, sIBM & Safety Signals
Gene Therapy vs Peptide Vials: The Brutal Gap
Timeline, Stacking & Practical Reality
Side Effects, Risks & Unknowns
Sourcing Mess & Bigger Picture (Dystrophy > Vanity)
Rapid FAQ: Does It Work? Localized? Safe for Women?
Final Honest Assessment
Link to SLUPP-332 Podcast

If you've experimented with follistatin peptides or gene therapy, drop your experience (gains, sides, source) in the comments—no judgment, just signal.

🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.

#Follistatin344 #MyostatinInhibitor #MuscleGrowth #GeneTherapy #Biohacking #Follistatin #Myostatin #Longevity #BryanJohnson #PEDs #AntiAging #Human5.0Project #PeptideScience #BodybuildingScience #HealthOptimization#Ultimatebiohacker10x
...more
15min
February 11, 2026Erythritol Exposed: “Zero Sugar” Might Not Be Zero Risk (BBB + Stroke Signal)
Zero-Sugar, Real Consequences: Erythritol, Clotting, and Brain Vessel Function

You’re in the aisle making the “smart” swap: zero-sugar energy drinks, keto bars, sugar-free gum. Feels like a win… until the science starts whispering a different story.
In this episode, UltimateBiohacker10X breaks down why erythritol (a “natural” sugar alcohol used everywhere in keto/low-carb) is getting serious scrutiny—from cardiovascular event associations to a newer lab study showing direct impacts on brain microvascular endothelial cells (the cells that help form the blood–brain barrier).
This is educational only — not medical advice. If you have vascular risks, clotting history, diabetes/metabolic disease, migraines with aura, or take meds/supplements that affect clotting or blood pressure, talk to a qualified clinician before changing anything.
What we cover
Why erythritol got “safe” status + why that doesn’t equal “risk-free”
The 2023 signal: higher blood erythritol levels associated with major adverse cardiac events (heart attack, stroke, death)
The 2025 lab data: erythritol exposure linked with
Oxidative stress up
Nitric oxide down (less vasodilation)
Endothelin-1 up (more vasoconstriction)
t-PA release blunted (reduced fibrinolysis / “clot-busting” capacity)
Who may be highest risk (daily high-dose users / “keto stackers”)
Practical action steps: label scanning, dose awareness, and smarter swaps
“Vascular shields” lifestyle stack (sleep, zone 2, omega-3s, nitrates from greens/beets)
Action steps (no panic, just signal)
Scan labels: erythritol hides inside “sugar-free,” “keto,” and blends (monk fruit/stevia mixes).
Check your dose: occasional gum ≠ daily drinks + bars + candy. Cumulative exposure matters.
Consider alternatives: stevia/monk fruit/allulose have different profiles (and still need more data).
Train sweetness down: the simplest win is reducing the craving for constant sweetness.
💬 Comment “666FDA” + your topic of concern and I’ll add it to the next breakdown.

Sources to look up (by title)
“The artificial sweetener erythritol and cardiovascular event risk” (Nature Medicine, 2023)
“The non-nutritive sweetener erythritol adversely affects brain microvascular endothelial cell function…” (Journal of Applied Physiology, 2025)
World Health Organization guideline: “Use of non-sugar sweeteners” (May 15, 2023)
Cleveland Clinic summary on thrombosis/platelet reactivity (Aug 2024)
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
#Erythritol #ZeroSugar #Keto#BloodBrainBarrier #StrokeRisk #EndothelialHealth #CardiovascularHealth #SugarAlcohol #ArtificialSweeteners #NutritionScience #MetabolicHealth #Inflammation #OxidativeStress #NitricOxide #Thrombosis #HeartHealth #BrainHealth #Biohacking #Longevity #HumanPerformance #TheHuman50Project #UltimateBiohacker10X
...more
7min
February 10, 2026How to Test Your True Biological Age in 2026 – Epigenetic Clocks, Telomeres & Results Explained
Biological Age vs Chronological Age: The Real Tests That Tell You How Old You Actually Are

Ever wonder why two people the same age feel completely different? Your driver’s license is just a number—your cells have their own clock. In this episode, we break down chronological, genetic (intrinsic), and biological age, plus the top tests that reveal how fast you’re actually aging: telomere length, epigenetic clocks (Horvath, GrimAge, PhenoAge, DunedinPACE), TruDiagnostic, Elysium, GlycanAge, and more.
We cover:

How telomere shortening and DNA methylation drive aging
At-home testing: spit, finger prick, blood spot—what to expect
What your results mean (and the limitations)
Why these tests are game-changers for longevity, healthspan, and motivation
Intro: Your body’s real age
The three ages explained
Telomeres, methylation & epigenetics
The tests: which ones actually work
Interpreting results & red flags
Why you should care (and what to change)
Final thoughts & action plan
If you’ve run a biological age test, drop your results in the comments—what did it say, and what did you do about it?
Subscribe for more cutting-edge biohacking, longevity science, and optimization protocols. Hit the bell so you never miss an update.

🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.

#BiologicalAge #EpigeneticClock #AgingScience #ReverseAging #Telomeres #DNAMethylation #Longevity #Biohacking #Human5.0 #TruDiagnostic #GrimAge #DunedinPACE #HealthOptimization #AntiAging #Biohacker
...more
10min
February 09, 2026AMPK Activation Explained: Exercise + Fasting + mTOR Balance (2026 Guide)
Stop Chasing Hacks: AMPK + mTOR + Fasting + Exercise
Cold plunges are the headline… but AMPK is the real story. In this episode, UltimateBiohacker10X breaks down AMPK (your cell’s low-energy switch) in plain English, then shows how to activate it without living in an ice bath—using exercise, fasting/low glycogen, and recovery strategy.

We also add the missing piece most people ignore: mTOR—the “build mode” signal. The goal isn’t “AMPK forever” or “mTOR forever.” The goal is cycling stress → recovery → adaptation so you don’t become a metabolic hostage.

No hype. Just mechanisms + measurement, plus a clean 30-day framework so you can run one lane, track outcomes, and stop stacking chaos.

What you’ll learn:

What AMPK actually does (fuel use + efficiency mode)

Why exercise is the king AMPK trigger

How fasting can help (and how people misuse it)

AMPK vs mTOR: efficiency mode vs build mode (why balance = longevity)

Red flags you’re overdrafting recovery

A simple 30-day experiment framework (goal → baseline → measure → stop rule)
Open — Cold isn’t the point
Disclaimer + rules (foundations first)
AMPK explained like you’re human (low-battery mode)
Myth buster — more AMPK isn’t always better
Activator #1: Exercise (the cleanest AMPK trigger)
Activator #2: Fasting / low glycogen (powerful, easy to misuse)
AMPK vs mTOR (growth mode vs efficiency mode)
“Beyond basics” — research tools vs real life (don’t stack chaos)
Safety + red flags (overdrafting recovery)
30-day “run it clean” framework
Close — cycle stress + recovery, measure everything

🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
#AMPK #mTOR #Fasting #IntermittentFasting #ExerciseScience #Zone2 #HIIT #MetabolicHealth #FatOxidation #Mitochondria #Longevity #Autophagy #InsulinSensitivity #Biohacking #HealthOptimization #UltimateBiohacker10X #Recovery #StrengthTraining #MetabolicFlexibility #ColdExposure
...more
12min
February 09, 2026Cold Plunge Science 2026: AMPK, Brown Fat, Mitochondria & What Actually Changes
AMPK Explained Simply: How Cold Exposure Triggers Fat Burning, Glucose Uptake & “Cell Cleanup”

Cold exposure isn’t a masculinity contest — it’s a stimulus. And the real story is what happens inside your cells when energy demand spikes.

In this episode, UltimateBiohacker10X breaks down AMPK (5' AMP-activated protein kinase) in plain English: your body’s internal “low fuel” switch that shifts you from storage/build mode into use/repair mode. We connect AMPK to cold thermogenesis, brown fat (BAT), mitochondrial signaling, and give you safe, repeatable protocols (cold showers → cold walks → cold plunge) without the ego traps.

No hype. Just signal: how to use cold as an amplifier, what outcomes are realistic, and what to track so you don’t confuse vibes with results.

NOT medical advice. If you have heart rhythm issues, Raynaud’s, cold urticaria, fainting history, pregnancy, or uncontrolled BP—talk to a clinician and don’t do cold water exposure alone.

If you want Part 2: “AMPK Activators Beyond Cold (exercise, fasting, sleep)” comment AMPK2.

🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
Cold isn’t the point (open)
Disclaimer + safety rules (don’t be a hero)
AMPK explained like you’re human (fuel gauge / low power mode)
What actually flips AMPK on (energy demand triggers)
AMPK downstream effects (fuel partitioning + repair/efficiency)
Cold thermogenesis: what it is vs. what it isn’t
Brown fat (BAT) + why results vary person-to-person
Practical protocols (cold shower → cold walk → cold plunge)
How to measure results + stop rules (adult framework)
Close + next episode teaser

#AMPK #ColdThermogenesis #ColdExposure #IceBath #ColdPlunge #Biohacking #MetabolicHealth #FatLossScience #MetabolicFlexibility #BrownFat #Mitochondria #GlucoseControl #Autophagy #Recovery #PerformanceHealth #UltimateBiohacker10X #NoHype #HealthOptimization #WellnessScience #2026Biohacking#TheHuman5.0Project
...more
15min
February 08, 2026Peptides 2026: Evidence Ladder + Quality Red Flags (Don’t Get Played)Part2
Peptides Masterclass Part 2: Evidence Tiers + Purity Red Flags (No Hype)
People love peptide “stacks.” Reality loves baselines, evidence tiers, and stop rules.

Part 1(click here)

In Part 2 of the Peptides Masterclass, UltimateBiohacker10X breaks down the Evidence Ladder (Tier 1 human RCTs → Tier 2 small human/mechanistic → Tier 3 preclinical/early) and the Quality Red Flags that turn “biohacking” into expensive confusion.

We run the 5 peptide buckets people actually search:
Fat loss: GLP-1 context + AOD-9604 reality check
Injury/Recovery: BPC-157 + TB-500 (what we know vs what’s assumed)
Sleep/Brain: Selank, Semax, DSIP (mechanism ≠ outcome)
Longevity/Immune: TA1, MOTS-c, KPV (define longevity with metrics)
Skin/Hair: GHK-Cu + topical penetration reality (physics > marketing)

Rule #1 stays undefeated: foundations first. If you aren’t tracking baselines, you aren’t doing an experiment—you’re doing a vibe.
Educational only. Not medical advice. No dosing. No sourcing. Consult a qualified clinician for personalized decisions.

🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
Open — Evidence Ladder + “Don’t get played”
Evidence Ladder explained (Tier 1 / 2 / 3)
Bucket 1 — Fat loss (GLP-1s + AOD-9604 evidence + red flags)
Bucket 2 — Injury/Recovery (BPC-157 + TB-500 reality check)
Bucket 3 — Sleep/Brain (Selank, Semax, DSIP: what’s real vs wanted)
Bucket 4 — Longevity/Immune (TA1, MOTS-c, KPV: evidence ladder)
Bucket 5 — Skin/Hair (GHK-Cu + topical penetration reality)
Universal Quality Red Flags (purity, stacking, no baseline)
Close — pick one lane, measure, stop rules

#Peptides #Biohacking #Longevity #HealthOptimization #NoHype #EvidenceBased #Wellness #Recovery #SleepHacks #FatLoss #GLP1 #BPC157 #TB500 #Semax #Selank #DSIP #MOTSc #ThymosinAlpha1 #GHKCu #SkincareScience #AntiAging #FitnessScience #UltimateBiohacker10X #HumanPerformance #2026#TheHuman5.0Project
...more
12min
February 08, 2026Peptides in 2026: 5 Reasons People Use Them + A No-Hype Framework (Fat Loss, Recovery, Sleep, Longevity)
Peptides Masterclass (2026): The 5 Buckets + How to Run a Clean Experiment
Peptides are trending in 2026 for five reasons: fat loss, injury recovery, sleep/brain performance, longevity/inflammation, and skin/hair. In this no-hype masterclass, UltimateBiohacker10X breaks down what each bucket is trying to do, where evidence is stronger vs thinner, and the adult decision framework that keeps you from getting played:

✅ Foundations first
✅ Goal → baseline → measure → stop rule
✅ One lane at a time (no stacking chaos)
✅ Track outcomes, not vibes

Comment “PEPTIDES2” if you want Part 2: Evidence Ladder + Quality Red Flags.

DOWNLOAD: Peptide Dosing Guide
DOWNLOAD: Outline For The Episode/Peptide Masterclass (and how to follow it cohesively)
Open — 5 reasons people search peptides
Ground rules + disclaimer
Rule #1 — foundations first
Bucket 1 — fat loss (context + measurement)
Bucket 2 — injury/recovery (reality check + rehab first)
Bucket 3 — sleep/brain (hierarchy + tracking)
Bucket 4 — longevity/inflammation (scorecard thinking)
Bucket 5 — skin/hair (topical reality + SPF)
Decision framework (goal → baseline → measure → stop rule)
Peptides and when to use them
Close
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.

#Peptides #Biohacking #Longevity #FatLoss #Recovery #SleepOptimization #HRV #BodyComposition #AntiAging #UltimateBiohacker10X #Healthspan #FitnessScience#TheHuman5.0Project
...more
16min
February 07, 2026VIP Peptide 2026: What It Really Does for Inflammation, Gut Health & Anti-Aging (No Hype Guide)
In this 30-minute masterclass, UltimateBiohacker10X breaks down VIP (Vasoactive Intestinal Peptide): endogenous vs. aviptadil, mechanisms (vasodilation, anti-inflammatory), evidence from RCTs (COVID/ARDS trials), benefits (respiratory, neuroprotection, skincare), safety (BP drops, GI effects), and a no-BS decision framework. Plus: quality warnings and better alternatives like sleep/conditioning. No fluff—just signal for biohackers chasing real outcomes.
Open
Ground Rules
VIP 101
Mechanism
VIP vs Aviptadil
Plausible Uses
Safety
Decision Framework
Don’t Get Played
Alternatives
Close
Comment: What's your top inflammation hack? #VIPPeptide

🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if you're sourcing research peptides , peptidesphere.com has a curated selection of peptides and bioregulators with detailed info on quality and applications.
#VIPPeptide #Biohacking #AntiInflammatory #GutHealth #AntiAging #Neuroprotection #Peptides #Longevity #InflammationHacks #UltimateBiohacker10X #Health#TheHuman5.0Project
...more
10min

FAQs about The Human 5.0 Project:

How many episodes does The Human 5.0 Project have?

The podcast currently has 112 episodes available.