By Dr. Alfred Granite

Dr. Granite's newsletter explores the CRISPR-Cas9 technology, tracing its accidental discovery in bacteria to its potential for revolutionizing healthcare. It emphasizes the rigorous scientific process behind CRISPR's development, contrasting it with politically motivated endeavors. The newsletter highlights the FDA's approval of Casgevy and Lyfgenia, the first CRISPR-based treatments for sickle cell disease, while also acknowledging challenges like chemotherapy requirements and high costs. Dr. Granite points to resources that help explain the complex technology, emphasizing its role in future genetic medicine, using videos and podcasts for easier understanding. The article also explores LUCA, the Last Universal Common Ancestor, as a way to highlight genetics and the fundamental building blocks of life and the possibilities for AI to discover new uses.

Newsletter: https://the-human-condition.beehiiv.com 

By Dr. Alfred Granite

This document highlights the dangers of ultra-processed foods (UPFs) and their correlation with the rise of chronic illnesses. UPFs are factory-made products with extracted ingredients and additives, and examples include packaged snacks, sugary drinks, and processed meats. The document emphasizes that UPFs are calorie-dense, lack essential nutrients, and are designed to be addictive, leading to overconsumption and weight gain. It cites studies linking high UPF consumption to increased mortality, type 2 diabetes, cardiovascular disease, and other health issues. The author suggests strategies for reducing UPF intake, such as cooking at home, choosing whole foods, and reading nutrition labels. The document then proposes legislative solutions like regulating the promotion of unhealthy foods and setting strong dietary guidelines.

Newsletter: https://the-human-condition.beehiiv.com

By Dr. Alfred Granite

Dr. Granite explores the evolution of healthcare, tracing it from ancient agricultural societies to the present. He introduces hyper-personalized medicine, a revolutionary approach tailoring treatments to individuals based on their genetics, lifestyle, and environment. This approach utilizes advanced technologies like CRISPR and wearable devices to provide more effective and precise care. The article also discusses the application of personalized medicine in elite sports, focusing on training optimization, injury prevention, and nutrition. Finally, it highlights the importance of integrating lifestyle and environmental factors for achieving optimal health outcomes, emphasizing the role of diet, exercise, sleep, and environmental pollutants.

Newsletter: https://the-human-condition.beehiiv.com

By Dr. Alfred Granite

Dr. Granite's analysis reveals significant flaws in the American healthcare system, contrasting it unfavorably with systems in other developed nations. Key issues highlighted include exorbitant costs, limited access, poor health outcomes, and excessive administrative complexity. The text also explores the problematic influence of Big Pharma and the FDA's reliance on industry funding, hindering the approval of potentially beneficial, yet non-patentable, treatments. Proposed solutions range from immediate measures like increased price transparency and expanded coverage to more sweeping reforms, including government oversight of the FDA and Big Pharma, to improve affordability and equity. Ultimately, the author advocates for systemic change to achieve better health outcomes and reduce the financial burden on American citizens.

Newsletter: https://the-human-condition.beehiiv.com

By Dr. Alfred Granite

This edition of The Human Condition explores the shift from symptom-based medicine (Medicine 2.0) to root-cause-focused, preventative care (Medicine 3.0). It highlights plasmapheresis as a promising longevity treatment and delves into emerging therapies like hyperbaric oxygen, ozone, hormone, and peptide therapies, emphasizing their potential in anti-aging and healthspan improvement. Advocating for these advances, the author predicts greater future accessibility and encourages readers to prioritize understanding and addressing the root causes of illness. 

https://the-human-condition.beehiiv.com/p/plasmapheresis-and-new-wellness-therapies

By Dr. Alfred Granite

This podcast that discusses the alarming rise in chronic diseases among American older adults and now children, attributing it primarily to poor diet and a lack of physical activity. The author connects this to the widespread consumption of ultra-processed foods and the historical shift in human diets from hunter-gatherer patterns to an abundance of readily available, often unhealthy, options. The piece also touches upon the controversial views of Robert F. Kennedy Jr. on vaccines and fluoride, while emphasizing the importance of a balanced diet like the Mediterranean or ketogenic diets, and the need to understand the nutritional value of food sources, particularly emphasizing the importance of natural, unprocessed foods. 

https://the-human-condition.beehiiv.com/p/where-are-we-going

By Dr. Alfred Granite

1. Peripheral Neuropathy (PN): Explanation of the condition, its symptoms, causes, and stages. ​
2. Personal Experience: The author's personal account of living with PN and the impact it had on their life. ​
3. Treatment and Management: Discussion on various treatments and lifestyle changes that can help manage PN, including diet, supplements, and physical therapies. ​
4. Diet and Nutrition: Emphasis on the importance of consuming high-quality fats and avoiding trans fats for nerve health. ​
5. Peptides and Supplements: Information on specific peptides and supplements that can aid in nerve regeneration. ​
6. Red/Near-Red Light Therapy: Recommendation of red light therapy for stimulating nerve regeneration and details on a specific product. ​
7. Misconceptions about Fats: Clarification on the misconceptions about saturated fats and the dangers of trans fats. ​

Link: https://the-human-condition.beehiiv.com/p/peripheripheral-neuropathy

 By Dr. Alfred Granite

This podcast discusses the link between metabolic dysfunction and chronic diseases, arguing that poor diet and environmental toxins stemming from technological advancements are major contributing factors. Dr. Granite highlights the detrimental effects of trans fats and the role of mitochondrial dysfunction in various illnesses. He advocates for the use of artificial intelligence to address both healthcare challenges and environmental problems caused by human activity, suggesting AI can improve diagnostics, treatment, and efficiency while mitigating the negative consequences of technological progress. 

This chapter also includes a podcast featuring Professor Thomas Seyfried on a new treatment for cancer without chemotherapy or radiation and another one featuring Dr. Loyd Minor, dean of Stanford Medical School on AI’s future role in healthcare and medical education. Ultimately, he promotes a proactive and holistic approach to health and wellness, incorporating both lifestyle modifications and technological solutions.
 
Read THE HUMAN CONDITION newsletter:
https://the-human-condition.beehiiv.com/the-big-picture

By Dr. Alfred Granite

This chapter provides a comprehensive overview of Alzheimer's disease, exploring its history, underlying biology, and current and emerging treatments. Key features discussed include the role of amyloid plaques and neurofibrillary tangles, genetic factors like the APOE gene, and the development of new blood tests for diagnosis. The text also emphasizes nutritional approaches, advocating for low-carbohydrate diets and the use of ketones, coconut oil, and MCT oil to combat insulin resistance and improve brain function.

There is also an important video featuring Dr. Dale Bredesen, one of today's leadinding authorities on Alzheimer's who advocates a NEW individualized functional approach that has slowed and even reversed progression in hundreds of people.

Newsletter: https://the-human-condition.beehiiv.com

By Dr. Alfred Granite

This podcast delves into the escalating global diabetes epidemic, clarifying the differences between type 1 and type 2 diabetes. Type 2 diabetes, the most common form, arises primarily from insulin resistance, driven by modern diet and lifestyle factors. This episode explores the connection between insulin resistance and various age-related diseases, including neurodegenerative conditions, and highlights the potential role of an evolutionary dietary mismatch in their development. Practical dietary recommendations to combat insulin resistance are discussed, focusing on the benefits of whole foods while minimizing processed carbohydrates, sugar, and unhealthy fats. Finally, the Sardinian lifestyle is presented as a model for longevity, emphasizing a diet rich in healthy fats and an active, community-centered way of life. 

Newsletter: https://the-human-condition.beehiiv.com