Ready to learn about the secret compounds, molecules, nootropics, and stacks that Big Pharma doesn’t want you to know about? This episode is packed with the exact dopamine-boosting compounds, stacks, and biohacking protocols that top performers are using to supercharge human performance, brain optimization, and long-term resilience. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Lucas Aoun, Australia’s leading biohacker and founder of Ergogenic Health. Known for his fearless, data-driven experimentation, Lucas specializes in nootropics, dopamine modulation, mitochondria, and functional medicine. He’s spent over a decade testing underground compounds, natural molecules, and hormone-based strategies to achieve elite-level brain and body performance. 

Together, they explore Russian-developed enhancers like Bromantane and ITPP, and reveal how these rare compounds impact dopamine regulation, neuroplasticity, and mental drive. You’ll learn how to upregulate tyrosine hydroxylase (your brain’s dopamine switch), build targeted stacks for motivation and confidence, and avoid the common supplements that quietly kill your ambition. 

They also dive into the connection between dopamine and testosterone, explaining how to rewire hormonal feedback loops to reclaim masculinity, energy, and purpose. From libido hacks and prolactin suppression to stacking dopamine with GABA and acetylcholine, this episode gives you a complete system for motivation mastery. 

Other key topics include the dangers of chronic ashwagandha use, sleep optimization for dopamine recovery, the truth about adaptogens and cold therapy, ketosis, fasting, DHT science, ciproheptadine microdosing, and why mitochondrial support is essential for long-term performance and metabolism. 

You’ll Learn: 

• The #1 Russian compound for explosive dopamine and drive 

• Why most “calming” supplements destroy your ambition 

• How dopamine and DHT shape masculinity and performance 

• Advanced biohacks for sleep, motivation, libido, and mood 

• The truth about serotonin dominance and how to escape it 

• Which functional medicine tools enhance brain energy and metabolism 

• How to build your own dopamine protocol using proven nootropics 

• Why mitochondrial health is the hidden key to motivation and mood 

This is essential listening for anyone serious about biohacking, brain optimization, hormone hacking, nootropics, functional medicine, emotional resilience, and building a state of unstoppable energy. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

 Thank you to our sponsors!  

• OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY.  
• Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  
• LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE. 

 Resources:  

• Lucas’s Website: https://www.boostyourbiology.com/ 

• Lucas’s YouTube: https://www.youtube.com/c/boostyourbiology 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Tags:  

dopamine boosters, russian nootropics, bromantane benefits, biohacking dopamine, boost motivation naturally, dopamine stack, lucas aoun podcast, dave asprey dopamine, nootropics for energy, secret russian compounds, brain optimization, biohacking supplements, increase dopamine levels, functional medicine hacks, hormone optimization, dopamine and testosterone, neuroplasticity hacks, superhuman energy, underground nootropics, dopamine protocols 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Getting 50 grams of protein per meal may be the single most underrated biohacking protein strategy for muscle growth, metabolism, and longevity. In this episode, you’ll discover why animal protein vs vegan is not a fair match biologically, how hitting the leucine threshold activates mTOR for longevity, and why muscle is the most overlooked organ of aging. This is must-listen content for anyone optimizing human performance, hacking metabolism, or reversing muscle loss with food. 

Host Dave Asprey is joined by Dr. Gabrielle Lyon, a pioneer in Muscle-Centric Medicine®, functional medicine expert, and top authority on clinical nutrition for longevity. Trained by protein researcher Dr. Donald Layman, she brings decades of expertise on how to use high-protein diets, amino acid science, and functional medicine to radically improve healthspan and brain optimization. Dr. Lyon works with everyone from special operators to aging patients, making her one of the most trusted voices in anti-aging diet strategies. 

Watch this channel on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

You’ll learn: 

• Why 50g of protein per meal matters more than total daily intake 

• How mTOR and longevity are misunderstood in mainstream nutrition 

• Why protein vs plant protein debates ignore hard biological data 

• How leucine thresholds determine muscle activation 

• Why fasting and protein cycling beats low-protein veganism 

• How ketosis and protein intake impact metabolic health 

• Why many on a vegan diet experience sleep issues, hormone crashes, and reduced resilience 

• How functional medicine podcasts like this one reveal the truth about aging and muscle loss 

• What happens clinically when patients switch to a high-protein diet 

• How to use supplements, nootropics, and protein hacks to enhance neuroplasticity, mitochondrial energy, and total body performance 

If you’ve ever asked “what’s the best protein for muscle growth?” or “how does protein affect metabolism in aging?”, this episode gives you evidence-based answers from the front lines of clinical nutrition. 

This channel is a must-listen for anyone serious about hacking their biology, upgrading cognitive performance, and using unconventional tools to create lasting transformation. Whether you’re tracking HRV, optimizing for deep sleep, or working toward metabolic resilience, these conversations deliver insights you won’t hear anywhere else. 

 Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

 Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

 Thank you to our sponsors!  

• 40 Years of Zen | Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 
• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.  
• Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. 

 Resources:   

• Gabrielle’s Website: https://drgabriellelyon.com/ 

• Gabrielle’s IG: https://www.instagram.com/drgabriellelyon/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 0:00 Trailer 

• 0:51 Protein Controversy  

• 2:38 Leucine 

• 6:00 mTOR, Methionine, and Protein Synthesis 

• 9:00 Vegan vs. Carnivore 

• 16:00 Optimizing Protein Intake & Aging 

• 22:00 Carbohydrates, Hormones, and Female Health 

• 28:00 Environmental Impact & Food Sourcing 

• 34:00 Debunking Plant-Based Documentaries 

• 40:00 Key Takeaways & Closing 

Keywords: protein vs plant protein, 50 grams of protein, biohacking protein, mTOR and longevity, animal protein vs vegan, leucine threshold, Gabrielle Lyon, muscle-centric medicine, best protein for muscle growth, anti-aging diet, muscle as organ of longevity, fasting and protein, ketosis and protein, vegan diet risks, optimizing metabolism, high-protein diet, functional medicine podcast, Dave Asprey protein, aging and muscle loss, clinical nutrition for longevity 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode reveals how military-grade sound frequencies can rapidly shift your mental state, enhance neuroplasticity, and accelerate brain optimization. You’ll learn how to hack your nervous system using real-time biometric data, how frequency compositions are changing functional medicine, and why sound is emerging as one of the most powerful tools for human performance and longevity. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey is joined by Rev. Michael Beckwith, founder of the internationally renowned Agape International Spiritual Center and one of the most respected voices in spiritual transformation and human potential. With over four decades of teaching, Michael has impacted millions through his work in consciousness, meditation, and high-performance inner development. Joining him is Henry Penix, founder of SOAAK Technologies, a cutting-edge frequency healing platform trusted by clinicians, elite performers, and even the US Air Force. Together, they explore how sound can rewire brainwaves, reduce anxiety, support sleep optimization, and create measurable changes in metabolism, mood, and mindset. 

 You’ll learn: 

• How the Air Force is using frequency tech to support mental recovery and cognitive performance 

• What makes SOAAK’s custom sound compositions biologically effective 

• How sound impacts mitochondria, mood, and brainwave coherence 

• The link between sound healing, neuroplasticity, and high-performance states 

• Why hydration, supplements, and biohacking stacks boost sound-based protocols 

• The surprising connection between prayer, frequency, and emotional regulation 

• How to integrate sound biohacks with fasting, ketosis, sleep tools, and nootropics 

• Why this tech pairs with cold therapy, Danger Coffee, and smarter not harder principles 

This channel is a must-listen for anyone serious about hacking their biology, upgrading cognitive performance, and using unconventional tools to create lasting transformation. Whether you’re tracking HRV, optimizing for deep sleep, or working toward metabolic resilience, these conversations deliver insights you won’t hear anywhere else.  

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

 Thank you to our sponsors!  

• Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.  
• Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order.  
• ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order 

 Resources:  

• SOAAK Website: https://www.soaak.com/dave 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 0:00 — Trailer 

• 1:00 — Intro 

• 2:42 — Humor & Frequency 

• 5:20 — Soak App Origins 

• 8:15 — Biometrics & Sound Delivery 

• 10:40 — Inner Alignment & Brain Mapping 

• 13:46 — Beckwith’s Results 

• 19:44 — Sound & Biohacking 

• 23:32 — Mood & Sleep Shifts 

• 24:53 — Supplements & Water Synergy 

• 26:25 — Emotional Congruence 

• 29:49 — Frequency & Sexuality 

• 32:43 — Military & Medicine 

• 35:32 — Light, Sound & Quantum Effects 

• 40:34 — Analog vs. Digital Sound 

• 48:45 — Spiritual Experiences 

• 53:14 — Conclusion & CTA 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You’ve been lied to about how long it takes to change a habit. This episode reveals a powerful, science-backed method to rewire your brain in just 63 seconds—without relying on willpower. You’ll discover how to use the 63-second window to interrupt destructive thought loops and how true habit change requires 63-day habit formation, not the popularized 21-day myth. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Caroline Leaf, a cognitive neuroscientist and best-selling author known for her groundbreaking work on the mind-brain connection. With over four decades of experience, Dr. Leaf has helped millions better understand the differences between the mind vs brain, how to harness intuition and neurobiology, and how to apply science-based tools for healing trauma with neuroscience. Her newest work, Help in a Hurry, builds on her bestselling book Cleaning Up Your Mental Mess, offering real-time tools to regain mental control during moments of emotional chaos. 

 You’ll learn: 

• Why the 21-day habit myth persists and what the neuroscience actually shows 

• How to use the 63-second window to stop toxic thoughts from wiring into your brain 

• What happens during the 63-day habit formation cycle and how to stay on track 

• The difference between the subconscious vs unconscious mind 

• How to rewire your brain for better emotional regulation and decision-making 

• The power of forgiveness and how it relates to quantum entanglement 

• Caroline Leaf’s mental mess strategies to overcome triggers in real time 

• Why the free will neuroscience debate matters for your mental sovereignty 

• How to interpret intuitive “blips” through a neuroscience lens 

• Tools for using neuroplasticity to heal trauma, manage emotions, and boost clarity 

This episode is a must-listen for anyone interested in brain optimization, biohacking, human performance, mental resilience, and smarter-not-harder strategies for personal growth. Whether you’re focused on fasting, cold therapy, nootropics, sleep optimization, or upgrading your mitochondria, these mental frameworks will amplify your results. 

 Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

 Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Thank you to our sponsors!  

• Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order 
• IGNITON | Save 10% at https://endlss.io/sl/igniton/daveasprey 

Resources:  

• Order Caroline’s New Book ‘Help in a Hurry’ - https://a.co/d/6O9RaJB 

• Caroline's Website: https://drleaf.com/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

 Timestamps: 

• 0:00 Trailer 

• 0:54 Intro 

• 1:12 63-Second Habit Rule 

• 5:14 21 vs 63 Days 

• 9:20 Habits vs Trauma 

• 14:19 Healing & Spiritual Insight 

• 17:43 Free Will & Mind-Brain Link 

• 19:11 Conscious vs Subconscious 

• 26:02 Intuition & Memory 

• 33:15 AI & Consciousness 

• 37:56 Death & Energy 

• 51:21 Forgiveness & Entanglement 

• 55:14 Self-Regulation Tools 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What is Herbal Ecstasy—and why does it matter? This might be one of the most insane episodes we’ve ever recorded, and we had to bring it back because the story is too wild, too relevant, and too packed with real lessons in biohacking, brain optimization, and supplement hacking to miss. 

Host Dave Asprey sits down with Shaahin Cheyene, the renegade teenage entrepreneur who built a billion-dollar supplement empire before he could legally drink. As the creator of Herbal Ecstasy, Shaahin hacked natural compounds into high-performance nootropics that boosted energy, neuroplasticity, and metabolism—long before biohacking was a movement. He faced seven federal investigations, never spent a day in jail, and went on to pioneer the vaporizer industry and dominate Amazon with advanced supplement marketing. 

 This episode explores how Shaahin reverse-engineered functional medicine principles, used ancient plant medicine to upgrade human performance, and scaled a controversial brand using raw hustle and hacking tactics. You’ll hear how Herbal Ecstasy worked, why it was banned, and what it teaches us about supplements, mitochondrial function, dopamine regulation, and the dark politics behind wellness innovation. 

 You’ll learn: 

• Why Herbal Ecstasy became a billion-dollar underground supplement 

• How Shaahin used nootropics and adaptogens to hack energy, focus, and neuroplasticity 

• What his clash with the FDA reveals about supplement regulation and functional medicine 

• How dopamine, mitochondria, and metabolism drive human performance 

• The difference between hacking systems vs conforming to broken ones 

• How storytelling, podcasting, and controversial supplements build legacy brands 

Whether you’re optimizing your sleep, hacking your brain, experimenting with ketosis or fasting, or upgrading your stack with supplements that actually work—this channel delivers strategies, cautionary tales, and insight you won’t find anywhere else. lt is essential listening for anyone serious about biohacking, brain optimization, supplements, mitochondria, metabolism, functional medicine, nootropics, longevity, dopamine, cold therapy, sleep optimization, emotional regulation, neuroplasticity, fasting, podcasting, RFK-era health freedom, ketosis, entrepreneurship, and building influence smarter not harder—with or without Danger Coffee. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Thank you to our sponsors!  

Resources:  

• Shaahin’s Website: https://www.shaahincheyenne.com/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 0:00 — Trailer 

• 0:45 — Intro and guest setup 

• 4:39 — Escaping Iran and early hustle 

• 8:26 — Birth of Herbal Ecstasy 

• 14:21 — Explosive growth and legal heat 

• 25:06 — Lessons on money and business 

• 31:17 — Inventing the digital vaporizer 

• 40:03 — Hacking success on Amazon 

• 41:59 — Nootropics and the Limitless pill 

• 46:38 — Martial arts and mental resilience 

• 55:44 — Podcasting, media, and influence 

• 1:07:09 — Where to find Shaahin and closing thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You’re leaving brainpower on the table, and this episode shows you how to reclaim it. Learn how to boost cognitive performance by 25% without relying on pills, stimulants, or gimmicks. Host Dave Asprey sits down with global finance expert and cross-cultural thinker Richard Conrad to explore how your cultural programming shapes your biology, metabolism, neuroplasticity, and even your ability to reach peak human performance. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Richard is the author of Culture Hacks and has spent over 30 years living and working across Japan, China, and the U.S. He’s a master of decoding hidden mental frameworks that influence perception, longevity, and decision-making. This is a must-listen if you care about brain optimization, functional medicine, and living smarter, not harder. 

Together, they break down why different cultures process truth, time, and identity so differently and how these filters influence your beliefs about supplements, fasting, cold therapy, sleep optimization, and more. You’ll also learn why Americans are biologically wired for linear logic, how agrarian versus warrior cultures shaped meditation and nervous system regulation, and how to train your mitochondria to perform like a samurai’s. 

You’ll Learn: 

• Why your culture shapes how your brain processes reality 

• How to shift from linear to systems thinking for better neuroplasticity 

• The connection between meditation styles, nervous system wiring, and mitochondria 

• How to apply ancient frameworks to modern biohacking and human performance 

• Why longevity without financial planning is a broken strategy 

• How to avoid cognitive bias by decoding relative versus absolute truth 

This channel is packed with biohacking wisdom, from nootropics and ketosis to Danger Coffee, financial resilience, and how your beliefs about aging could be accelerating it. Whether you’re focused on hacking your brain, upgrading your metabolism, or extending your longevity, this is one of the most unique mind-expanding channels around. It is essential listening for anyone passionate about biohacking longevity, functional aging, mitochondrial testing, and next-gen human optimization. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Thank you to our sponsors!  

• Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.  
• OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. 
• Generation Lab | Go to https://generationlab.com/, use code DAVE20 for $20 off, and see what your body’s really doing behind the surface. 

Resources:  

• Order Richard’s Book “Culture Hacks”: https://a.co/d/9122Q25 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 01:10 Intro 

• 03:15 Middle East Perception Gap 

• 06:53 China’s Strategy & Trade 

• 09:53 Japan vs China Mindsets 

• 14:28 Logic: East vs West 

• 18:23 Cultural Tools for Life 

• 24:23 Global Population Crash 

• 30:18 Shifting Economic Power 

• 55:33 Smart Finance Principles 

• 01:09:28 Real Estate & Policy 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This may be the most cutting-edge life extension technology you’ll hear about for decades. You’ll discover how mitochondrial transfusion, rejuvenation, and repair could reverse biological aging, supercharge your metabolism, and radically extend healthspan—all by upgrading the cellular energy systems that power every function in your body. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with inventor and tech entrepreneur Tom Benson, founder of Mitrix. After launching three successful Silicon Valley companies, Benson shifted focus to one of the most promising frontiers in science: mitochondrial bioreactors designed to regrow your own autologous mitochondria. This isn’t theory—it’s a near-future anti-aging technology poised to transform functional medicine, personalized medicine, and the global conversation around aging reversal. 

They explore how mitochondrial DNA mismatches affect aging, why mitochondria act like cellular AI cores, and how dysfunction in these ancient organelles contributes to neurodegenerative disease, metabolic decline, and cognitive disorders. You’ll learn how restoring mitochondria could enhance everything from stem cell therapy and nootropics to ketosis, fasting, cold therapy, and even sleep optimization. 

 You’ll Learn: 

• Why mitochondria may be the real control centers of human biology 

• How mitochondrial transfusion could revolutionize longevity and functional medicine 

• The connection between mitochondrial dysfunction and Parkinson’s, autism, and ALS 

• Why brain optimization and neuroplasticity depend on cellular energy 

• How stem cell-derived mitochondria compare to nootropics and NAD 

• What happens when mitochondrial DNA and nuclear DNA are mismatched 

• Why early aging might start with your egg cells’ mitochondrial computing 

• How mitochondrial health influences metabolism, ketosis, and fat storage 

• Why stress, toxins, and pharmaceuticals like statins wreck mitochondrial function 

• What it takes to scale mitochondrial bioreactors for widespread human use 

• How mitochondrial hacking could improve immune function, sleep, and resilience 

• Why the future of biohacking might begin with testing and upgrading your mitochondria 

This episode is essential listening for anyone passionate about biohacking longevity, functional aging, mitochondrial testing, and next-gen human optimization. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Thank you to our sponsors!  

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.  

-Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order. 

Resources:  

• Mitrix Website: https://www.mitrix.bio/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 01:42 Intro 

• 04:33 Mitochondrial DNA & Performance 

• 08:49 Challenges in Mitochondrial Therapy 

• 13:31 Future Applications 

• 19:07 Mitochondria & Longevity 

• 20:19 Traditional Medicine 

• 28:50 Space Exploration 

• 29:35 Human Fragility 

• 30:19 Aging Revisited 

• 32:52 Experimental Research 

• 36:04 Ethics & Risks 

• 41:24 Mental Health Links 

• 46:28 Treatment Breakthroughs 

• 51:01 Personal Longevity Hacks 

• 54:30 Wrap-Up & Contact 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if one spray could upgrade your brain, protect your mitochondria, and outperform IV therapy and liposomal supplements? In this episode, you’ll discover the breakthrough science behind topical glutathione delivery that uses your skin’s water channels to raise intracellular glutathione levels in just 60 seconds. Learn how this powerful antioxidant works at the cellular level to reduce oxidative stress, support mitochondrial function, and drive real improvements in brain health, emotional resilience, and human performance. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Nayan Patel, a world-leading pharmacist and formulator who pioneered this next-gen delivery method. With over two decades of clinical work in functional medicine, Nayan has helped reshape how we think about glutathione benefits, systemic detox, and performance optimization. His research shows that topical delivery bypasses traditional fat-based absorption, achieving higher brain uptake and faster results than IVs or capsules. 

 You’ll learn: 

• Why glutathione for longevity is foundational to biohacking 

• How it protects against cellular inflammation and improves TBI recovery issues 

• Why pairing glutathione with NAD+, vitamin C, or pharmaceutical nicotine creates a powerful synergy 

• How it preserves NAD+, supports sirtuins, and enhances ATP production 

• When to use glutathione as an immune booster for resilience and recovery 

This conversation also reveals the truth behind liposomal supplements, how your age affects glutathione absorption, and why this molecule is critical for anyone using nootropics, in ketosis, or pushing metabolic limits. 

This episode is essential listening for anyone into biohacking, cold therapy, functional medicine, or RFK-style medical freedom. You’ll walk away with practical tools to boost nitric oxide naturally, prevent dysfunction, and optimize your biology whether you’re on a carnivore diet or just looking for an edge. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Resources:  

• Auro Wellness Website: Use code ‘dave10’ at checkout https://aurowellness.com/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 00:20 Intro 

• 01:12 Water Channel Delivery Explained 

• 02:25 What Makes Glutathione Special 

• 05:04 Why IVs and Liposomes Fail 

• 06:29 Measuring Glutathione in the Brain 

• 10:42 Key Benefits and Use Cases 

• 20:49 Emotional Resilience Effects 

• 23:54 Sensitivity and Response 

• 24:55 Best Timing for Use 

• 25:53 Workout Performance Boost 

• 26:47 Brain Health and TBI Support 

• 28:22 Best Stack Combinations 

• 29:32 Nicotine + Glutathione Synergy 

• 33:18 Longevity, Sirtuins, and Genes 

• 40:36 Glutathione as Immune Booster 

• 43:15 Peptides and Next-Gen Hacks 

• 45:29 Dosing Tips and Wrap-Up 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you care about longevity, brain optimization, sexual performance, or metabolism, this molecule changes everything. Host Dave Asprey sits down with nitric oxide pioneer Dr. Nathan Bryan to reveal why this overlooked molecule controls your blood flow, mitochondrial energy, neuroplasticity, insulin response, and even your libido. You’ll learn how nitric oxide acts as a master switch for human performance and why the medical system has ignored it for decades. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Dr. Nathan Bryan is a world-renowned expert in nitric oxide biochemistry with over 20 years of clinical research, multiple patents, and collaborations with Nobel Prize-winning scientists. His groundbreaking work forms the foundation for modern functional medicine protocols targeting blood flow, metabolism, cognitive enhancement, and mitochondrial upgrades. 

You’ll learn: 

• How nitric oxide drives mitochondria, metabolism, and human performance 

• Why most nitric oxide supplements fail and how to spot real ones 

• The critical role nitric oxide plays in brain optimization, libido, and insulin signaling 

• How poor oral health, statins, and PPIs can kill nitric oxide production 

• What nitric oxide has to do with sleep optimization, aging, and disease prevention 

• How to stack nitric oxide with fasting, ketosis, nootropics, red light, and supplements 

• Why “Smarter Not Harder” starts with nitric oxide fueled upgrades 

This episode is essential listening for anyone into biohacking, cold therapy, functional medicine, or RFK-style medical freedom. You’ll walk away with practical tools to boost nitric oxide naturally, prevent dysfunction, and optimize your biology whether you’re on a carnivore diet or just looking for an edge. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Get Nitric Oxide products for 10% off with code ‘Dave’: https://bit.ly/Nitric-Oxide-Product 

SPONSORS: 

• Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. 
• Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

Resources:  

• Nathan’s Website: https://www.n1o1.com 

• Nathan’s YouTube: https://www.youtube.com/channel/UCtftGy8e0r9DO8ActcyGi4w 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 01:03 Intro 

• 01:15 Why Medicine Ignores Nitric Oxide 

• 01:59 What Nitric Oxide Does in the Body 

• 04:46 How the Body Makes Nitric Oxide 

• 07:12 Diet’s Impact on NO Levels 

• 13:28 Why Most NO Supplements Fail 

• 19:32 Personalized Biohacking with NO 

• 22:33 How Medicine Misses the Mark 

• 30:40 Oral Health and Nitric Oxide 

• 31:30 Mouthwash Kills Your Microbiome 

• 32:28 The Problem with Fluoride 

• 33:25 Better Toothpaste for NO 

• 33:49 NO’s Role in Energy and Healing 

• 34:17 Blood Pressure and NO 

• 35:29 NO and Sexual Performance 

• 37:09 NO and COVID Recovery 

• 40:50 Brain Fog and NO Deficiency 

• 49:01 Carnivore, Sugar, and NO 

• 50:11 Why You Still Need NO Supplements 

• 54:19 Final Takeaways 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Supercharge your mitochondria, slash inflammation, and boost energy with one of the most overlooked hacks in human performance. This episode reveals how just 15 minutes of oxygen-based exercise can radically improve metabolism, brain optimization, and even reverse chronic conditions, without expensive gear or endless protocols. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Brad Pitzele, founder of One Thousand Roads and creator of the LEO System, an affordable and science-backed way to do Exercise With Oxygen Therapy (EWOT) at home. After nearly dying from autoimmune illness and failed functional medicine treatments, Brad used this oxygen-based biohacking tool to fully reboot his health. His story and system offer breakthrough potential for anyone facing fatigue, inflammation, or looking to upgrade energy, resilience, and longevity. 

 You’ll learn: 

• How EWOT works differently from hyperbaric oxygen and why it’s faster 

• Why brain fog, poor sleep, and chronic inflammation all trace back to oxygen supply 

• How oxygen hacking activates neuroplasticity, detox pathways, and energy production 

• When to stack with ketosis, red light, nootropics, and mitochondrial supplements 

• How elite athletes and chronically ill patients both use this protocol 

• Why “Smarter Not Harder” starts with oxygen-fueled mitochondrial upgrades 

This is essential listening for anyone serious about biohacking, functional medicine, brain optimization, metabolism, fasting, supplements, and longevity. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Get a free Ebook on EWOT to learn more today:

https://cdn.shopify.com/s/files/1/0097/3186/6683/files/The_Oxygen_Advantage_Protocol_-_EWOT.pdf?v=1752173567 

SPONSORS: 

• Puori | Head to http://puori.com/dave for 20% off, including subscriptions.  
• BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.  
• Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 

Resources:  

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

• One Thousand Roads Website: https://www.onethousandroads.com/

• One Thousand Roads YouTube (more info on EWOT) : https://www.youtube.com/@OneThousandRoadsHQ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Labs: https://upgradelabs.com 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 01:10 Introduction 

• 02:38 Discovering EWOT 

• 03:55 Autoimmune Breakdown 

• 06:54 Building One Thousand Roads 

• 15:00 EWOT Science & Benefits 

• 20:54 Protocols & Use Cases 

• 29:03 Real-World Results 

• 30:11 Brain Fog & Oxygen 

• 30:58 Athletic Performance 

• 31:41 Therapy Stacking 

• 34:44 Mitochondria & Aging 

• 37:08 Research & Studies 

• 40:00 Future of Oxygen Therapy 

• 43:02 Practical Tips & Access 

• 51:09 Final Takeaways 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.