The Journal Club

The Journal Club

By Beimnet KassayeScience
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The Journal Club episodes

  • #9 The Western diet and Alzheimer's disease (First half with Stedman Stephens)

    In this episode, Stedman and I cover the first half of a paper by Poxleitner et al., 2024. The title of the paper is "Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis." Here is the PubMed link for the article https://pubmed.ncbi.nlm.nih.gov/38745337/. You may access the paper by clicking on the icons under the "Full Text Links" tab.

    Here are the webpages of Dr. Herfert and Dr. Beziere respectively:

    http://www.isct.uni-tuebingen.de/wsic/research/research-groups/neurology/functional-and-metabolic-brain-imaging

    http://www.isct.uni-tuebingen.de/wsic/research/research-groups/immunology-inflammation/inflammation

    You may access other publications and the current focuses of their lab by following the links.

    The music for this podcast was composed by Marko Krtinic, and if you would like to check out his work and support him, please visit his Spotify account at https://open.spotify.com/artist/6bJaFvgKIirKMoox9cGHWC?si=_Ou5UC-BRXebl_S7AH-kGg.

    22 min
  • #8 APOE4 and Alzheimer's disease

    In this episode, I cover a paper by Wang et al., 2021. The title of the paper is "Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia." Here is the PubMed link for the article https://pubmed.ncbi.nlm.nih.gov/33831349/. You may access the paper by clicking on the icons under the "Full Text Links" tab.

    Here is the webpage of the Holtzman lab: https://holtzmanlab.wustl.edu. You may access other publications and the current focuses of the lab by following the link.

    The music for this podcast was composed by Marko Krtinic, and if you would like to check out his work and support him, please visit his Spotify account at https://open.spotify.com/artist/6bJaFvgKIirKMoox9cGHWC?si=_Ou5UC-BRXebl_S7AH-kGg.

    15 min
  • #7 Neuroinflammation in Alzheimer's disease

    In this episode, I cover a paper by Kummer et al., 2021. The title of the paper is "Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology." Here is the PubMed link for the article https://pubmed.ncbi.nlm.nih.gov/34825707/. You may access the paper by clicking on the icons under the "Full Text Links" tab.

    Here is the webpage of the Heneka lab: https://www.iiibonn.de/michael-heneka-lab/michael-heneka-lab-science. You may access other publications and the current focuses of the lab by following the link.

    The music for this podcast was composed by Marko Krtinic, and if you would like to check out his work and support him, please visit his Spotify account at https://open.spotify.com/artist/6bJaFvgKIirKMoox9cGHWC?si=_Ou5UC-BRXebl_S7AH-kGg.

    20 min
  • #6 How does the gut microbiome contribute to Alzheimer's disease?

    In this episode, I cover a paper by Grabrucker et al., 2023. The title of the paper is "Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis." Here is the PubMed link for the article https://pubmed.ncbi.nlm.nih.gov/37849234/. You may access the paper by clicking on the icons under the "Full Text Links" tab.

    Here is the webpage of the Nolan lab: https://research.ucc.ie/profiles/C003/ynolan. You may access other publications and the current focuses of the lab by following the link.

    The music for this podcast was composed by Marko Krtinic, and if you would like to check out his work and support him, please visit his Spotify account at https://open.spotify.com/artist/6bJaFvgKIirKMoox9cGHWC?si=_Ou5UC-BRXebl_S7AH-kGg.

    17 min
  • #5 Alzheimer's disease, amyloid plaques and tau tangles

    In this episode, I cover a paper by Zeng et al., 2023. The title of the paper is "Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease." Here is the PubMed link for the article https://pubmed.ncbi.nlm.nih.gov/36732642/. You may access the paper by clicking on the icons under the "Full Text Links" tab.

    Here is the webpage of the Wang lab: https://www.wangxiaolab.org. You may access other publications and the current focuses of the lab by following the link.

    The music for this podcast was composed by Marko Krtinic, and if you would like to check out his work and support him, please visit his Spotify account at https://open.spotify.com/artist/6bJaFvgKIirKMoox9cGHWC?si=_Ou5UC-BRXebl_S7AH-kGg.

    20 min
  • #4 Oxygen imaging of hypoxic pockets in the mouse cerebral cortex

    In this episode, I cover a paper by Beinlich et al., 2024. The title of the paper is "Oxygen imaging of hypoxic pockets in the mouse cerebral cortex." Here is the PubMed link for the article https://pubmed.ncbi.nlm.nih.gov/38547288/. You may access the paper by clicking on the icons under the "Full Text Links" tab.

    Here is the webpage of the Nedergaard lab: https://www.urmc.rochester.edu/labs/nedergaard.aspx. You may access other publications and the current focuses of the lab by following the link.

    The music for this podcast was composed by Marko Krtinic, and if you would like to check out his work and support him, please visit his Spotify account at https://open.spotify.com/artist/6bJaFvgKIirKMoox9cGHWC?si=_Ou5UC-BRXebl_S7AH-kGg.

    16 min
  • #3 Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures

    In this episode, I cover a paper by McCafferty et al., 2023. The title of the paper is "Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures" Here is the PubMed link for the article https://pubmed.ncbi.nlm.nih.gov/36627270/. You may access the paper by clicking on the icons under the "Full Text Links" tab.

    You may have noticed that the episode had intro music. The tune was composed by Marko Krtinic, and if you would like to check out his work and support him, please visit his Spotify account at https://open.spotify.com/artist/6bJaFvgKIirKMoox9cGHWC?si=_Ou5UC-BRXebl_S7AH-kGg.

    16 min
  • #2 Improvement of sensory deficits in fragile X mice by increasing cortical interneuron activity after the critical period

    In this episode, I cover a paper by Kourdougli et al., 2023. The title of the paper is "Improvement of sensory deficits in fragile X mice by increasing cortical interneuron activity after the critical period." Here is the PubMed link for the article https://pubmed.ncbi.nlm.nih.gov/37451263/. You may access the paper by clicking on the CellPress OpenAccess icon under the "Full Text Links" tab.

    You may have noticed that the episode had intro music. The tune was composed by Marko Krtinic, and if you would like to check out his work and support him, please visit his Spotify account at https://open.spotify.com/artist/6bJaFvgKIirKMoox9cGHWC?si=_Ou5UC-BRXebl_S7AH-kGg.

    17 min

About The Journal Club

From the publisher's feed

This podcast is structured as a short scientific journal club where I will discuss scientific papers and relate their major findings. Generally, journal clubs have a scientific audience ranging…