The Journal Club

Lin H, Ma C, Cai K, Guo L, Wang X, Lv L, Zhang C, Lin J, Zhang D, Ye C, Wang T, Huang S, Han J, Zhang Z, Gao J, Zhang M, Pu Z, Li F, Guo Y, Zhou X, Qin C, Yi F, Yu X, Kong W, Jiang C, Sun JP. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Science. 2025 May

Beyer JN, Serebrenik YV, Toy K, Najar MA, Feierman E, Raniszewski NR, Korb E, Shalem O, Burslem GM. Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins. Science. 2025 May

Zhou S, Li M, Wang P, Guo C, Zhang J, Luo X, Fan YC, Chen EQ, Qi X, Chen J, Ye L, Yuan HY, Yin WB, Wang K, Zheng MH, Pang Y, Qiao J, Jiang C. A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite-CerS6-ceramide axis. Science. 2025 May

Anderson JT, DeMarche ML, Denney DA, Breckheimer I, Santangelo J, Wadgymar SM. Adaptation and gene flow are insufficient to rescue a montane plant under climate change. Science. 2025 May

Lyu C, Li Z, Xu C, Wong KKL, Luginbuhl DJ, McLaughlin CN, Xie Q, Li T, Li H, Luo L. Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit. Science. 2025 May

Zhang Y, Cohen OY, Moshe M, Sharon E. Geometrically frustrated rose petals. Science. 2025

A single gene helps rice handle the heat.

Discovery could preserve grain quality and yields as climate

change raises temperatures; Erik Stokstad

Science May 1, 2025

Redated artifacts rewrite how Indigenous people responded to European contactFresh radiocarbon data challenge archaeologists’ assumptions about North America’s Indigenous history; Lizzie Wade⁠

Hunt for tree rings could yield Africa’s first drought atlasRecords could reveal how much humanity has altered Sahel rains; Paul Voosen

Science May 1, 2025

Xu, Q., Lui, S., Ji, Y. et al. Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits. Nat Neurosci 28, 676–687 (2025).

Langdon, C., Engel, T.A. Latent circuit inference from heterogeneous neural responses during cognitive tasks. Nat Neurosci 28, 665–675 (2025).