The Journal Club

This study shows that during navigation, the parietal cortex (PC) encodes upcoming egocentric actions and conveys them to the hippocampus, which initially encodes allocentric place information but gradually shifts to future goal-directed actions. Bidirectional communication between the PC and hippocampus integrates allocentric, route-centered, and egocentric reference frames to support spatial memory and navigation.

Zheng 征亦诚 Y, Zhou 周信羽 X, Moseley SC, Ragsdale SM, Alday LJ, Wu 吴畏 W, Wilber AA. A Hippocampal-Parietal Network for Reference Frame Coordination. J Neurosci. 2025 Apr 23;

Basu S, Waghade A, Parveen R, Kushwaha A, Mitra S, Kokare DM, Singru PS. CART neurons in the hypothalamic ventral premammillary nucleus (PMv) in rats mediate maternal, but not inter-male aggression. J Neurosci. 2025 Mar 14

This study shows that maternal aggression in rats is driven by activation of CART-expressing neurons in the ventral premammillary nucleus (vPMv), which signal to the ventrolateral ventromedial hypothalamus (VMHvl), while inter-male aggression involves the lateral PMv (lPMv) without CART dependence. CART is identified as a critical mediator specifically for maternal aggression through the PMv–VMHvl pathway.

Kedia, S., Simons, M. Oligodendrocytes in Alzheimer’s disease pathophysiology. Nat Neurosci 28, 446–456 (2025)

Abellanas, M.A., Purnapatre, M., Burgaletto, C. et al. Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease. Nat Neurosci 28, 436–445 (2025). https://doi-org.ccmain.ohionet.org/10.1038/s41593-024-01847-5

Nagasawa M, Mitsui S, En S, Ohtani N, Ohta M, Sakuma Y, Onaka T, Mogi K, Kikusui T. Social evolution. Oxytocin-gaze positive loop and the coevolution of human-dog bonds. Science. 2015 Apr 17

Glasser MF, Coalson TS, Robinson EC, Hacker CD, Harwell J, Yacoub E, Ugurbil K, Andersson J, Beckmann CF, Jenkinson M, Smith SM, Van Essen DC. A multi-modal parcellation of human cerebral cortex. Nature. 2016 Aug 11

Llibre-Guerra, J.J., Fernandez, M.V.,Joseph-Mathurin, N. et al. Longitudinal analysis of a dominantlyinherited Alzheimer disease mutation carrier protected from dementia. Nat Med 31,

Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD,Wade KJ, Bartley CM, Kizer K, Augusto DG, Tubati A, Gomez R, Fouassier C, Gerungan C, Caspar CM, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG,Baranzini SE, Zamvil SS, Sabatino JJ Jr, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BAC, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR. An autoantibody signature predictive for multiple sclerosis. Nat Med. 2024 May;30Wilson MR, Abdelhak A. Proteomic Profiling andPathophysiological Implications in Multiple Sclerosis. Neurol NeuroimmunolNeuroinflamm. 2025 Jan;12

Risky moves. Can blocking “jumping genes” treat diseases and aging?

These studies reveals that rodents exhibit rapid learning supported by distinct higher-order signals in the auditory cortex, separating learning from performance. Additionally, mice demonstrate structured, dynamic strategies—including choice biases and environmental probing—that suggest the use of internal models and flexible decision-making throughout learning.Zhu Z, Kuchibhotla KV. Performance errors during rodent learning reflect a dynamic choice strategy. Curr Biol. 2024 May 20

Drieu C, Zhu Z, Wang Z, Fuller K, Wang A, Elnozahy S, Kuchibhotla K. Rapid emergence of latent knowledge in the sensory cortex drives learning. Nature. 2025 Mar 19.