Claire Liefferinckx discusses her work with the Belgian Inflammatory Bowel Disease research and development group (BIRD) to capture real-world outcomes of ustekinumab treatment for Crohn’s disease, using a large national cohort of patients with a history of significant previous biologic exposure.

Sarit Hoffman describes her work measuring faecal protease activity in patients with pouchitis, and linking this to specific bacteria and downstream effects on epithelial barrier function mediated via PAR2.

Prof Jean-Pierre Hugot describes his team’s work examining associations between contemporary frequency of NOD2 mutations in populations and estimated rates of death from the plague during the medieval period.

JCC Associate Editor Dr Tim Raine and Prof David Rubin discuss the latest data from the Chicago experience of using ciclosporin in patients with acute severe ulcerative colitis refractory to infliximab rescue therapy.

Dr Ramit Mahajan discusses his team’s work conducting the first randomised controlled trial of faecal microbial transplantation for patients with ulcerative colitis in remission.

Lihi Godny from the Rabin Medical Center, Petah-Tikva, Israel discusses her work linking fruit consumption to microbial diversity and reduced risk of pouchitis. This work generates possibly the first practical dietary advice for patients with an ileal pouch anal anastomosis.

Dr Alka Potdar and Dr Janine Bilsborough discuss their paper analysing genetic and transcriptomic sub-classifiers of small bowel Crohn’s and the associated phenotypic characteristics

Dr Ramit Mahajan discusses his team’s work conducting the first randomised controlled trial of faecal microbial transplantation for patients with ulcerative colitis in remission.