Are common laboratory doses of carprofen suitable for marmosets? In this episode, we sit down with Dr. Ekaterina Perminov, DVM, DACLAM to discuss her latest research on whether carprofen, a commonly used NSAID for pain relief, reaches effective levels in marmosets and the possible adverse side effects. Dr. Perminov is a Clinical Veterinarian at UC Irvine. She obtained her veterinary degree from Western University of Health Sciences and completed her laboratory animal training at the Salk Institute for Biological Studies. In our conversation, Dr. Perminov shares her journey into laboratory animal medicine, her early work with axolotls, and her experience being the first lab animal medicine resident at the Salk Institute. Dr. Perminov unpacks how she was able to identify the gaps in opioid research, the design and results of her study, and why her findings were surprising. We explore what the findings mean for analgesic protocols, why marmosets have become 'biomedical supermodels,' and the importance of multimodal approaches for pain management. Join us to discover the challenges and opportunities of working with marmosets, why analgesic care for research primates is essential, and what future research should focus on with Dr. Ekaterina Perminov!
Key Points From This Episode:
- How regenerative medical research with axolotls led her toward laboratory animal medicine.
- Background about her team at Salk and what each person was responsible for in the study.
- Why she regards marmosets as 'biomedical super-models' and their applicability to research.
- Get an overview of the study's hypothesis, its design, methods, and the unexpected results.
- A breakdown of the main takeaways from the paper and the limitations of the study.
- What to consider when administering carprofen to marmosets and its possible side effects.
- Dr. Perminov shares advice to researchers for administering carprofen to marmosets.
- Hear why she thinks research is needed on carprofen metabolism and pharmacokinetics.
- Insights into the challenges and opportunities of conducting a pharmacokinetics study.
Links Mentioned in Today's Episode:
Dr. Ekaterina Perminov on LinkedIn
UC Irvine
'Pharmacokinetics of Oral and Subcutaneous Carprofen in Common Marmosets (Callithrix jacchus)'
Salk Institute for Biological Studies
Western University of Health Sciences
Trinka Adamson on LinkedIn
Antonio Pinto-Duart on LinkedIn
Kuo-Fen Lee on LinkedInAmerican Association for Laboratory Animal Science (AALAS)
AALAS Learning Library
Email AALAS
Journal of the American Association for Laboratory Animal Science (JAALAS)The LASt Word: An AALAS Podcast