Too busy to read the Lens? Listen to our weekly summary here! In this week’s episode we discuss…

• In patients with ROP, neurodevelopmental outcomes do not differ between anti-VEGF and laser photocoagulation treatments.
• AS-OCT identifies plateau iris, which carries an 11-fold higher risk of progression to angle closure, making it a potentially useful screening tool.
• Patients presenting with ocular complaints, and those presenting to eye doctors, receive more timely care in GCA than those presenting to their PCP or with headache or systemic symptoms. 
• Depression is subjectively strongly associated with dry eye disease severity, but not associated with objective clinical signs.

Too busy to read the Lens? Listen to our weekly summary here! In this week’s episode we discuss:

• Despite a substantial burden of diabetic retinopathy outside metropolitan areas, nearly all diagnostic and treatment services are delivered in urban practices. 

• Real Architecture for 3D Tissues-Ocular Surface transplantation improved ocular surface disease in advanced aniridia-related keratopathy with an acceptable safety profile in a first-in-human clinical trial.

• Women, Black patients, and patients with socioeconomic challenges were significantly less likely to receive timely surgery for rhegmatogenous retinal detachment in a large US retrospective study.

• A novel prediction model combining placental and early neonatal factors accurately identified infants at risk for retinopathy of prematurity before routine screening begins.

Too busy to read the Lens? Listen to our weekly summary here! In this week’s episode we discuss:

• Vitamin B3 may help prevent the progression of ocular hypertension to primary open-angle glaucoma.

• Patients with chronic pain conditions are more likely to develop dry eye disease.

• Compared with PRP, PPV may yield better preservation of peripheral visual function and a favorable trend in DME.

• A smartphone application might be able to detect basal cell carcinoma and malignant melanoma.

Too busy to read the Lens? Listen to our weekly summary here! In this week’s episode, we discuss:

• Long-term, repeated intravitreal anti-VEGF injections were associated with a significantly increased risk of cataract surgery in the treated eye, with risk increasing in a dose-dependent manner.

• Prespecified OCT interpretation rules, particularly assessment of the TSNIT curve, accurately distinguished glaucomatous damage from myopic structural changes with high sensitivity and specificity.

• Delaying the initial retinopathy of prematurity screening examination until 34 weeks postmenstrual age in selected medium-risk infants safely reduced unnecessary examinations without missing treatment-requiring ROP.

• Subretinal AAV8-mediated PD-L1 gene therapy reduced retinal inflammation and preserved retinal structure and function in a rat model of autoimmune uveitis, suggesting a potential future immune-modulating treatment strategy.

Too busy to read the Lens? Listen to our weekly summary here! In this week's episode, we discuss:

• Calm mind, calm eye: mindfulness as an adjunct treatment in non-infectious uveitis

• See no evil, speak no evil? How reliable are AI-powered smart glasses in providing visually impaired assistance?

• Tarsorrhaphy may allow for accelerated epithelial healing of corneal grafts in penetrating keratoplasty

• Identifying retinal vulnerabilities and nonperfusion in proliferative diabetic retinopathy

• A new route for gene therapy helps close the schism in X-linked retinoschisis

Too busy to read the Lens? Listen to our weekly summary here! In this week’s episode we discuss:

• Ocular inflammation, (along with female sex and treatment interruptions) were significant risk factors for developing anti-adalimumab antibodies, which happened in approximately 1/5th of patients on treatment with Adalimumab.

• Thinning of the ganglion cell layer/inner plexiform layer and outer retinal layers in children with type 1 diabetes was associated with higher A1c values.

• A review of methicillin-resistant staphylococcus aureus keratitis showed high levels of multidrug resistance, but all were susceptible to vancomycin. On average, there was no improvement in vision after treatment and a high number required procedural or surgical intervention.

Too busy to read the Lens? Listen to our weekly summary here! In this week’s episode we discuss:

• Myopic eyes with deformities on 3D-MRI had a higher risk of myopic complications over 15 years compared to nondeformed myopic eyes.

• Former smokers who switched to electronic cigarettes or heated tobacco had a higher risk of developing eye diseases compared to those who quit completely.

• In highly myopic children, an AI model accurately predicted future pathologic mai-o-pee-uh based on early microvascular and structural retinal changes.

• A greater baseline choroidal thickness predicted better long-term visual acuity in patients with intermediate uveitis.

Too busy to read the Lens? Listen to our weekly summary here! In this week’s episode we discuss:

• Large language models perform well on ophthalmic knowledge-based assessments but are not ready for patient-facing care alone.

• FOXC1 duplications play an exciting new role in understanding the genetics of JOAG.

• Children with ROP requiring treatment may face an increased long-term risk of development of strabismus and benefit from increased ophthalmic surveillance.

• A new study suggests the E2–ERβ–MMP2 signaling axis links estrogen imbalance to corneal collagen remodeling and biomechanical weakening in keratoconus pathology.

Too busy to read The Lens? Listen to our weekly summary here!

In this week's episode...

• Patients with obstructive sleep apnea demonstrate decreased macular vessel and perfusion density on OCT-A.
• FOXC1 duplication is shown to be a high-penetrance genetic variation associated with juvenile open-angle glaucoma.
• In metropolitan areas, children with retinoblastoma were less likely to receive enucleation or chemotherapy than those in non-metropolitan areas.
• OCT radiomic features were significantly correlated with axial length and visual acuity in patients with pathological myopia.
• Primary visual cortex mapping using functional MRI testing demonstrated high reproducibility in patients with geographic atrophy.

Too busy to read the Lens? Listen to our weekly summary here! In this week’s episode, we discuss:

• Acoltremon, a selective TRPM8 (cold-sensing receptor) agonist, increased natural tear production in patients with moderate-to-severe dry eye disease in two phase 3 trials (COMET-2 and COMET-3).

• Handheld OCT appears to be less stressful than traditional binocular indirect ophthalmoscopy for infants undergoing ROP screening. 

• In a retrospective analysis of patients with optic disc edema, researchers found that outpatient stat MRI pathways reduced cost and visit duration compared to emergency-room-based stat MRI pathways.  

• A retrospective TriNetX cohort study found that calcium channel blockers were associated with a higher risk of progression of primary open-angle glaucoma.