The Detroit Lions lost for only the second time during the 2024 season, falling to Josh Allen and the Buffalo Bills 48-42. Over their 11-game winning streak, the Lions had established themselves as one of the best teams in the NFL. Sunday's loss was particularly tough, as it felt like the first time this season that the Lions were not the more physical team. Carlton Davis III, Alim McNeill, David Montgomery, and Khalil Dorsey left the game with significant injuries.