The most played episodes among Podcast App listeners.

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   Number 1: Why Women Spend the Last 5–6 Years of Life in Worse Health Than Men (And What to Do About It)

   Why do women spend the last 5–6 years of life in worse health than men — and what does it have to do with your ovaries? Only 8–9% of NIH research funding goes to women’s health research, and by some estimates as little as 4% of private R&D investment goes to anything outside female cancers, fertility, and maternal-fetal health combined. Meanwhile, cardiovascular disease risk can rise 2–4x almost overnight at menopause — a shift most women are never warned about. In this episode, Chris is joined by Dr. Jennifer Garrison, PhD, a neuroscientist, Co-Founder and Executive Director of ProductiveHealth.org, who spearheads the science on ovarian health. Most people — including doctors — have conflated ovarian aging with reproductive aging for decades. Garrison’s research shows they’re not the same thing: ovaries function as a signaling hub for the entire body, and when they decline, they take whole-body health down with them, independent of fertility. In this episode, you’ll learn:Why ovarian aging and reproductive aging are two different things — and why that distinction matters for your whole-body healthWhat the research funding gap actually looks like, in numbersWhy the 2002 hormone therapy scare was based on flawed study design — and what the data actually shows todayWhy oral estradiol carries stroke risk but the transdermal patch doesn’tWhat a landmark mouse study revealed when researchers swapped old ovaries for young ones — and then removed the folliclesWhy cardiovascular risk changes so sharply at menopause, and when to get a baseline cardiac workupWhy the “four phases of your cycle” fitness trend oversimplifies the real scienceWhat Garrison would tell women in their 20s to start paying attention to now Want to learn more? Each month, we send a newsletter curated by our scientific council on what's actually advancing the science of human longevity — and what isn't. Subscribe at https://www.thewndrlab.com/mailing-list Links: Follow Dr. Garrison on LinkedIn Connect with our host Chris Wharton on Instagram: https://www.instagram.com/chriswharton1 Follow The LIVING Room Podcast on Socials: Instagram: https://www.instagram.com/the.living.room.pod/ LinkedIn: linkedin.com/company/wndrlab/ The WNDR Lab: https://www.thewndrlab.com/ Subscribe to our newsletter: https://www.thewndrlab.com/mailing-list Show Notes: 28andMe study: https://jacobs.psych.ucsb.edu/research/28-and-me https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003800 https://www.theinstitute.com/fellow/jennifer-garrison

   September 10, 2026·1h 29min
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   Number 2: This Peptide Burns Fat and Builds Muscle — But the Man Who Discovered It Won't Take It - Yet

   What's actually in the syringe when you buy a peptide off the black market? Now that the FDA regulation around 6 of these black market peptides is changing, should you be taking them? Should you be concerned about the link between GLP-1 use and lean tissue loss? Dr. Pinchas Cohen, PhD, is the scientist who co-discovered humanin and MOTS-c — two of the mitochondrial-derived peptides now driving the biggest wave of interest in longevity science — and he currently serves as Dean of the USC Leonard Davis School of Gerontology. Peptides have become a catch-all buzzword for a category that actually spans thousands of distinct molecules, most of them still unstudied. Dr. Cohen's lab discovered several of the ones people are now injecting themselves with, and he's spent the last year watching an unregulated market grow around his own research — to the point where he tested his friends' black-market MOTS-c and found some vials contained none of the peptide at all. Up to 30% of the weight lost on GLP-1 drugs is muscle. A genetic variant found in Ashkenazi Jews makes carriers roughly 20 times more likely to live to 100 and appears to blunt the effects of the biggest known Alzheimer's risk gene. In mice, MOTS-c extended lifespan by 10% and prevented the muscle and bone loss associated with GLP-1 use. And in July, 2026, Dr. Cohen testified in front of the FDA panel now reviewing MOTS-c's regulatory path. In this episode you'll learn:Why "peptides" make out three fundamentally different categories of molecules, not one trendHow MOTS-c and humanin were discovered inside DNA once dismissed as "junk"Why up to 30% of GLP-1 weight loss is muscle, and what that means over a decade of useWhat happened when Dr. Cohen tested the actual purity of black-market MOTS-cThe genetic variant linked to a 20x greater chance of living to 100Why he — the scientist who discovered MOTS-c — won't take it himself yetWhat the FDA's 503A compounding pathway means for legal access to peptidesWhere Alzheimer's and Parkinson's peptide research stands todayWant to learn more? Each month, we send a newsletter curated by our scientific council on what's actually advancing the science of human longevity — and what isn't. Subscribe at https://www.thewndrlab.com/mailing-list Check out The WNDR Lab Connect with Dr. Pinchas Cohen Connect with our host Chris Wharton on Instagram: instagram.com/chriswharton1 Follow The LIVING Room Podcast on Socials: Instagram: https://www.instagram.com/the.living.room.pod/ LinkedIn: linkedin.com/company/wndrlab/ The WNDR Lab: https://www.thewndrlab.com/ Show Notes Studies & Institutions referencedHealth and Retirement Study Kumagai's Japanese cohort GWAS (Genome-Wide Association Study)USC Leonard Davis School of Gerontology503AFDA PCAC panel Peptides & molecules HumaninMOTS-cSHLP SHMOOSE IGF-1, IGFBP-3ApoE4 / APOE (Alzheimer's risk gene)

   September 03, 2026·1h 30min
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   Number 3: Animals That Don't Age at All — What It Means for Us

   What is aging? Why is it the single biggest predictor of disease? And which of the most talked-about anti-aging interventions — telomere extension, biological age tests, supplements — actually hold up? In this conversation we talk to Dr. Vera Gorbunova and Dr. Andrei Seluanov who run a research lab together at the University of Rochester where they study the biology of aging across dozens of long-lived species — from naked mole rats to bowhead whales. A naked mole rat is roughly the size of a mouse but can live past 40 years — more than ten times a mouse's lifespan — and almost never develops tumors. Gorbunova and Seluanov's lab traced that resistance to a single molecule, and when they engineered mice to produce it, those mice developed about 50% fewer tumors and lived 10–15% longer. The same lab has also found a seaweed compound that extended mouse lifespan by 15%, studies a 200-year-old whale that carries 100 times more of a specific DNA-repair protein than humans do, and recently found that controlling a stretch of the genome once dismissed as "junk" nearly doubled the reproductive lifespan of mice. In this episode you'll learn: • What aging actually is, and why it happens in the first place - Why naked mole rats almost never get cancer — and the clogged lab-vacuum tube that led to the discovery • Why a naked mole rat gene cut tumors in half in mice and extended their lifespan • Why a 200-year-old whale has 100x more of a DNA-repair protein than humans — and whether cold plunges can activate it • Why longer telomeres don't make you live longer, and can raise cancer risk instead • How a gene variant found in human centenarians led to a seaweed compound that extended mouse lifespan 15% • How controlling the "dark genome" nearly doubled mice's reproductive lifespan, and what that might mean for delaying menopause • Why biological age tests can swing by years on the same day — and how to actually use them • Why the researchers say most anti-aging supplements are unproven — and which ones they still take themselves Connect with Dr. Vera Gorbunova: https://www.linkedin.com/in/vera-gorbunova-64a97b46/ Connect with Dr. Andrei Seluanov: https://www.linkedin.com/in/andrei-seluanov-52055b62/ Connect with our host Chris Wharton on Instagram: instagram.com/chriswharton1 Follow The LIVING Room Podcast on Socials: • Instagram: https://www.instagram.com/the.living.room.pod/ • LinkedIn: linkedin.com/company/wndrlab/ • The WNDR Lab: https://www.thewndrlab.com/ Want to learn more? Each month, we send a newsletter curated by our scientific council on what's actually advancing the science of human longevity — and what isn't. Subscribe at https://www.thewndrlab.com/mailing-list 3. Show Notes Institutions Referenced: The Gorbunova & Seluanov Laboratory at the University of Rochester Albert Einstein College of Medicine Research: Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold

   September 21, 2026·1h 30min
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   Number 4: Retinoids, Peptides and Injectables: A Dermatologist on What Works and What’s Overhyped

   Which anti-aging skincare products actually work according to science, and which are just hype? Board-certified dermatologist and Clinical Associate Professor of Dermatology at George Washington University, Dr. Noëlle Sherber cuts through the noise with an evidence-based breakdown of sunscreen, retinoids, peptides, injectables, and more. Anti-aging skincare has become so crowded with products, procedures, and conflicting advice that building an effective routine feels nearly impossible. Dr. Noëlle S. Sherber, a dermatologist specializing in collagen and connective tissue disorders, brings a clinical lens to skin longevity and explains why just six essentials — cleansing, antioxidants, hydration, moisturizer, sunscreen, and nighttime repair — form the only foundation you need. Dr. Sherber examines what tretinoin, over-the-counter retinoids, peptides, topical estrogen, red light therapy, and injectables can and cannot do, while unpacking skin barrier health, "digital dermatosis" (the algorithm-driven cycle that pushes you to buy more products), and "perception drift" (why you stop seeing your own results over time). This conversation with Chris Wharton on The LIVING Room Podcast is for anyone who wants healthier, younger-looking skin without a complicated 10-step routine or unsupported claims. You'll walk away knowing which fundamentals deserve your consistency, where advanced treatments actually fit, and how to make smarter decisions about your skin. Subscribe to our newsletter: https://www.thewndrlab.com/mailing-list The WNDR Lab: https://www.thewndrlab.com/ Connect with Dr. Noëlle Sherber: https://www.instagram.com/drnoellesherber Connect with our host Chris Wharton on Instagram: instagram.com/chriswharton1 Episode References: "Jam Study" and the paradox of choice:Iyengar SS, Lepper MR. When choice is demotivating: can one desire too much of a good thing? J Pers Soc Psychol. 2000 Dec; 79(6): 995-1006.full textPhotoaging benefits from a year of daily sunscreen:Randhawa M, Wang S, Leyden JJ, Cula GO, Pagnoni A, Southall MD. Daily use of a facial broad spectrum sunscreen over one-year significantly improves clinical evaluation of photoaging. Dermatol Surg. 2016 Dec; 42(12): 1354-1361.New sunscreen ingredient, BEMT / Tinosorb S, en route to FDA approval:https://www.fda.gov/news-events/press-announcements/fda-proposes-expanding-sunscreen-active-ingredient-listEffects of sunscreen use on vitamin D levels:Neale RE, Khan SR, Lucas RM, Waterhouse M, Whiteman DC, Olsen CM. The effect of sunscreen on vitamin D: a review. Br J Dermatol. 2019 Nov; 181(5): 907-915.A very recent peer-reviewed editorial regarding sunscreen safety and misinformation:Pissavini M, Kriekoukis O, Matts PJ, Nash JF, Sinclair C, Young AR, Diffey BL. A manifesto for informed sun protection advice in relation to sunscreens. Int J Cosmet Sci. 2026 Apr 3.full textSkin science on tretinoin:Baldwin HE, Nighland M, Kendall C, Mays DA, Grossman R, Newburger J. 40 years of topical tretinoin use in review. J Drugs Dermatol. 2013 Jun; 12(6): 638-42.full textTopical estrogens:Troxel J, Ferrer L, Iwamoto A, Van Voorhis B, Powers J. Topical estrogen therapy for aging skin: Current evidence and clinical considerations. JAAD Reviews, 2026 Mar; 7: 73-80.full textFarkas E, Goldblatt A, Nehorayan I, Lefkowitz RB, Fleshner L, Tepper K, Marmon S. Topical estrogen for skin aging: A systematic review of safety and efficacy. J Am Acad Dermatol. 2026 Jan; 94(1): 212-215. full textAirborne pollution's impact on skin health:Han HS, Seok J, Park KY. Air pollution and skin diseases. Ann Dermatol. 2025 Apr; 37(2): 53-67.full textSkin quality and age perception:Fink B, Matts PJ, Klingenberg H, Kuntze S, Weege B, Grammer K. Visual attention to variation in female facial skin color distribution. J Cosmet Dermatol. 2008 Jun; 7(2): 155-61.Fink B, Matts PJ. The effects of skin colour distribution and topography cues on the perception of female facial age and health. J Eur Acad Dermatol Venereol. 2008 Apr; 22(4): 493-8.Carbon CC, Leder H. The Mona Lisa effect: is 'our' Lisa fame or fake? Perception. 2006; 35(3): 411-4.Nicotinamide for skin cancer chemoprevention:Breglio KF, Knox KM, Hwang J, Weiss R, Maas K, Zhang S, Yao L, Madden C, Xu Y, Hartman RI, Wheless L. Nicotinamide for Skin Cancer Chemoprevention. JAMA Dermatol. 2025 Nov; 161(11): 1140-1147. Erratum in: JAMA Dermatol. 2025 Nov 1; 161(11): 1195. full text Nonablative fractionated laser treatment and keratinocyte cancer prevention:Benson TA, Hibler BP, Kotliar D, Avram M. Nonablative fractional laser treatment is associated with a decreased risk of subsequent facial keratinocyte carcinoma development. Dermatol Surg. 2023 Feb; 49(2): 149-154. Skinvive (called Volite overseas) and AQP-3 expression:Safa M, Natalizio A, Hee CK. A Prospective, Open-Label Study to Evaluate the Impact of VYC-12L Injection on Skin Quality Attributes in Healthy Volunteers. Clin Cosmet Investig Dermatol. 2022 Mar; 15: 411-426.full text

   August 19, 2026·1h 16min
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   Number 5: Neuroscientist Matthew Walker Destroys the Biggest Sleep Myths — From 5-Hour Nights to Melatonin Use

   What if everything you're doing for your health — the diet, the exercise, the supplements — depends on something you may be overlooking every night? Matthew Walker, PhD, neuroscientist, sleep expert, and professor of neuroscience and biomedical engineering at UT Dallas, founder of the Center for Human Sleep Science, and author of the New York Times bestseller Why We Sleep joins The LIVING Room Podcast to reveal why sleep is not the third pillar of health — it's the foundation on which everything else rests. For decades, we've treated sleep as the thing we'll fix after we get our diet, exercise, and productivity in order. But what if that order is exactly backwards? In this conversation, Dr. Walker explains why one night of 4 hours of sleep causes a 70% drop in cancer-fighting natural killer cells, how losing a single hour to daylight saving time spikes heart attack risk by 24%, and why dieting without enough sleep means up to 60% of the weight you lose comes from lean tissue — not fat. He unpacks the evolutionary paradox of why sleep exists at all, how dreaming acts as overnight emotional therapy by stripping stress chemistry from the brain, and why the single most powerful predictor of all-cause mortality isn't how long you sleep — it's how regular your wake time is. In this episode you'll learn: • Why one night of bad sleep causes a 70% drop in your immune system's cancer-fighting cells — and how quickly the damage begins • The daylight saving effect: why losing just one hour of sleep raises heart attack risk by 24% and what that reveals about chronic sleep loss • How insufficient sleep hijacks your metabolism so that 60% of weight lost during a diet comes from muscle, not fat • Why sleep exists in every species despite being evolutionarily absurd and what that universality tells us about its non-negotiable importance • How dreaming functions as overnight therapy, processing difficult emotional experiences in a brain state completely stripped of stress chemistry • Why sleep regularity — consistent wake times — predicts mortality more strongly than total sleep duration, and how to make it your single most powerful sleep lever • The truth about genetic short-sleepers: why they're rarer than being struck by lightning, and why you almost certainly aren't one Dr. Walker's research has been published in over 100 scientific studies, and he has been featured on CBS 60 Minutes, National Geographic, BBC, and NPR. He is one of the most cited and recognized sleep scientists in the world. If you've ever wondered whether 5 or 6 hours is enough, or felt like you're doing everything right for your health but not seeing the results — this conversation will fundamentally change how you think about the one-third of your life you spend asleep. Subscribe to our newsletter: https://www.thewndrlab.com/mailing-list The WNDR Lab: https://www.thewndrlab.com/ Timestamps: 00:00 – How Matthew became a sleep scientist 06:18 – Why sleep is the foundation of health (the 60% muscle loss study) 12:59 – One bad night: 70% drop in cancer-fighting killer cells 15:45 – Daylight saving: losing one hour spikes heart attack risk 24% 19:24 – Is the perception of sleep finally changing? 29:30 – The gold standard day for sleep: Matthew's full protocol 30:07 – Why wake-time regularity predicts mortality more than duration 36:42 – Daylight within 60 minutes of waking 40:04 – Strategic caffeine use: the half-life rule 46:47 – Exercise timing and your chronotype 49:08 – How to find your chronotype (the MEQ test) 52:49 – The evolutionary reason night owls exist 59:08 – What to do when you can't sleep 01:04:32 – The wind-down: sleep is like landing a plane 01:07:24 – Melatonin: what it actually does 01:12:46 – White noise and brown noise 01:16:50 – Sleep, cognition, and the aging brain 01:19:07 – Sleep's three roles in learning and memory 01:22:52 – How dream sleep builds creativity 01:24:49 – Athletic performance and motor skill improvement 01:36:22 – Poor sleep and emotional regulation (amygdala vs. prefrontal cortex) 01:38:24 – Quick-fire: controversial beliefs, underrated tools, advice to younger self 01:43:24 – Genetic short-sleepers: rarer than being struck by lightning 01:45:43 – Advice for aging parents: it's never too late 01:47:19 – Final message: "Sleep is your life support system" Episode References Dr. Walker's book Why We Sleep: Unlocking the Power of Sleep and Dreams TED Talk https://www.youtube.com/watch?v=5MuIMqhT8DM MEQ Chronotype Quiz https://reference.medscape.com/calculator/829/morningness-eveningness-questionnaire-meq Decibel Meter https://decibelpro.io/ 5 Techniques to fall asleep: Meditation, Box Breathing, Body Scan, Mental Walk & Sleep Stories Connect with Dr. Walker: https://www.instagram.com/drmattwalker Connect with our host Chris Wharton: https://www.instagram.com/chriswharton1

   August 12, 2026·1h 52min
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