Lupus Forum Chair Ed Vital, from the University of Leeds, is joined by Professor Maria Dall’Era, Professor of Medicine and Chief of the Division of Rheumatology at the University of California in San Francisco, USA. Together, they discuss latest developments and perspectives in RNase therapy and patient-reported outcome quality measures in SLE, as well as serological predictors of renal flares.Lupus Forum Chair Ed Vital, from the University of Leeds, is joined by Professor Maria Dall’Era, Professor of Medicine and Chief of the Division of Rheumatology at the University of California in San Francisco, USA. Together, they discuss latest developments and perspectives in RNase therapy and patient-reported outcome quality measures in SLE, as well as serological predictors of renal flares.