Loosely based on the game Super Mario Sunshine. The Mario Bros, along with Peach and Toadsworth, head to Delfino Island for a nice vacation. But their plans are cut short when Mario is accused of polluting the place with goop! Forced to clean up the island, Mario soon discovers the real perpetrators, and their plot to ruin their peaceful vacation.

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Loosley based on the game Warioware: Move It. When Wario wins a group getaway to Caresaway Island, the Warioware Crew joins him for what they think will be a relaxing vacation. But they quickly discover that the island is home to a sinister spirit that seems to be hiding something about the true nature of the island. Can the crew solve the mystery?

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When Mario, Luigi, and Peach are sent through a portal to another world, Peach is shocked to meet her adoptive father in this paper world! The heroes have been summoned so they can help stop Paper Bowser. Can they find the three mighty objects? And can Mario and Paper Mario work together to crumple Bowser's scheme?

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When Peach decides to play a board game with Mario, Luigi, and Yoshi, something scary happens and the four are sucked into the game! Soon they discover that Toad, Koopa, Shy Guy, Bowser, and Boo are in the game too, and the only way out is to compete against each other and finish the game.

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When an epidemic hits the Mushroom Kingdom that turns Toads into blimps, the Mario Bros. must help with the cure. Can the ballooned Toads be saved? And can the bros. stop the menace who is behind this nefarious scheme?

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When the Mario Bros. learn that the X-Nauts are after a few pieces of a special key, they endeavor to stop them. But their adventure will take them to some wild places, including Wario Land. Can they triumph over the X-Nauts? And what exactly is this evil organization after?

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Loosely based on the side quest from Mario & Luigi: Bowser's Inside Story (3DS). When a disease known as Swollen-puffee-itis strikes Bowser's Domain, Bowser Jr determines to find the cure. A group who calls themselves the Best Fitness Friends provide the recipe, but things are not as they seem. Will Junior let the Koopalings help him? And is the BFF friend or foe?

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When the Mushroom Kingdom hosts a laughing conference put on by Woohoo Hooniversity, Mario and the others learn about how important it is to laugh. But Mario isn't the biggest fan of this philosophy. Things are not all smiles and giggles, however, as a thief is lurking among the crowds to steal something valuable. This episode is sure to make you laugh (maybe even more than usual).

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The Narrator isn't happy when he finds out that he has to narrate a group of girls (with Peach in charge) as they go out on the town and have some fun. This episode features Pauline, Rosalina, Toadette, and Nabbit (for the first time).