When Mario and Luigi are captured by Bowser, Peach must muster all of her inner strength to go rescue them. With the help of her womanly powers (moods) and Perry the Parasol, she sets off for Vibe Island. Little does she know that Bowser has the Vibe Scepter, a powerful object which can control moods. Can Peach really save our heroes, or is this the end?

When Bowser's castle is taken over by the evil Midbus, Bowser turns to the only people he can trust to help him: the Mario Bros. But will the three be able to beat this dastardly villain? Can they even get along? Find out in this humorous upside-down episode. 

This episode tells the story of Wario Ware, Inc. How did it all happen? Well, as usual, it started with Wario being greedy. But you might be surprised how persuasive the big guy can be when he really wants something. Wario wants to make the craziest game ever, so he needs to find the craziest people ever. This one is nothing but crazy!

When Mario and Luigi find a plunger that fixes instantly with a simple touch, they decide to use it to make their job easy. But at the same time, the owners of this magic plunger are looking for their missing tool. Technical problems quickly ensue, and the Mario Bros. soon realize that they're in over their heads.

When a deadly mushroom disease sweeps across the Mushroom Kingdom, everyone gets very sick except for Mario. The famous Dr. Swall O. Pill entrusts his formula to Mario so people can get better. At the same time, Bowser swoops in to capture Princess Peach. Can Mario cure everyone in time to rescue Peach, or will the viruses ensure defeat?

This episode takes us back to 1990, when Bowser uses his family to help take over the Mushroom Kingdom. Mario and Luigi have their hands full this time, having to deal with the seven koopalings. They're the best family villain team ever, and Bowser decides to sing about it.

When Luigi wins a mansion in a contest, he and Mario go check it out. But things take a turn for the worse when Mario vanishes and Luigi discovers ghosts in the mansion! Luckily, Professor E. Gadd is there to help the young Mario Bro. Now it's up to Luigi to catch ghosts, find Mario, and get to the bottom of this ghostly problem. 

When another group of plumbers start stealing their business with the help of a TV commercial, Mario and Luigi decide to make their own commercial. With the help of Peach and Toad, they set off to make the best commercial money can buy. But will it be enough to save their careers?

When the ambassador from the Bean Bean Kingdom steals Peach's voice, Bowser teams up with the Mario Bros. to get it back. Along the way, Captain Toad and Prince Peasly (heir to the Bean Bean throne) join the crusade. Not only must they save Peach's voice, but they must also stop Fawful from getting his hands on the powerful Beanstar! 

Life is just fine and peachy for Luigi until he gets a letter from the dentist! Luigi is terrified to go to his annual appointment, but Mario demands that he be a man about it and go. Get ready for a mouth-full of laughs as Luigi endures one of life's greatest fears: the dental office!