The Med Lit Review

On this episode, we review the REDUCE trial asking if 5 days of steroids was non-inferior to a longer, 2 week course for patients with a COPD exacerbation. We go all in on non-inferiority trials and address Sean’s difficulty counting to 0. Listen in to what may have been our last in person recording 😔. But as always, please  leave a rating on Apple Podcasts and follow us on Instagram and Twitter @ Med_Lit_Review! We ❤️ your feedback! 🔥🥇💨

The team is BACK after a long, pandemic-filled hiatus. In this episode, we try to uncover which isotonic IV fluid is best using the SALT-ED trial. It's the showdown we've always wanted between lactated ringers and normal saline. We also talk about composite outcomes and multiplicity. Follow on Instagram and Twitter @Med_Lit_Review! And please leave us some feedback on the Apple Podcast app! 🧂🔥 

We hop into the RABBIT-2 trial to see how basal-bolus insulin plus correctional dose insulin compares to correctional dose insulin alone in the management of inpatient diabetes mellitus! We also make a quick stop in Stats Land to discuss repeated measures analysis of variance (ANOVA). Please leave a rating on Apple Podcasts and follow us on Instagram and Twitter @ Med_Lit_Review! 🔥🐰2️⃣

We venture into the MIND-USA trial on this episode to see if treating delirium in the ICU with antipsychotics reduces the # of days with delirium or coma! Our tour of Stats Land continues with a review blinding and multiplicity - yes, good old multiplicity. Plus, Rachel's mom gets a shout out (Hi, Susan!). Please leave a rating on Apple Podcasts and follow us on Instagram and Twitter @ Med_Lit_Review! 🔥 🧠 🇺🇸

In this episode, we review a trial comparing fecal transplant to oral vancomycin for the treatment of recurrent C. diff. We’ll review our C. diff treatments and talk about how authors decide when to terminate a study early. Sit back, relax, and listen to three residents discuss poop at length. As always, please follow on Instagram and Twitter @Med_Lit_Review! And please leave us some feedback on the Apple Podcast app!🔥💩

We checked out the VEST trial to see if patients with a low ejection fraction should use a wearable cardioverter-defibrillator in the immediate post-MI period. We review guideline recommendations and journey to Stats Land to talk about multiplicity. Please leave a rating on Apple Podcasts and follow us on Instagram and Twitter @ Med_Lit_Review! We ❤️ your feedback! 🔥⚡️

We dive into the SOME trial this week to see if we should more aggressively screen patients with an unprovoked DVT for occult malignancy. Join us on a trip to Stats Land where we touch on availability bias and different types of error. Please don’t forget to leave a rating on Apple Podcasts and follow us on Instagram and Twitter @ Med_Lit_Review! 🔥

This week, we discuss the HYPERION trial which looked at neurological outcomes with targeted temperature management after a cardiac arrest from NON-shockable rhythms. Please leave a rating on Apple Podcasts if you can and don’t forget to follow us on Instagram and Twitter @ Med_Lit_Review!!! 🔥❄️

Join us for a conversation about the SAGE-217 phase 2 trial, a new agent under investigation for the treatment of major depressive disorder! We talk about phases of trials, intention to treat vs. per-protocol analysis, and what the heck least mean square differences are. Follow us on Instagram and Twitter @Med_Lit_Review, and share your thoughts! 🔥

Join us for a discussion of the POET trial where we see whether or not it is safe and efficacious to complete endocarditis treatment with oral instead of intravenous antibiotics! We talk about assay sensitivity, study generalizability, and what the official language of Denmark is. Follow on Instagram and Twitter @Med_Lit_Review, we would LOVE your feedback. 🔥