In this episode, we speak with Dr. Holly Urban, VP of Business Development at Wolters Kluwer and a pediatrician-turned-health-IT-leader, about how UpToDate is bringing AI into clinical decision support without compromising safety or trust. She explains how UpToDate Expert AI grounds its responses exclusively in curated expert content, acts as a virtual attending physician by prompting clinicians with relevant considerations, and ensures full transparency by surfacing its assumptions and content sources. With 50 health systems already live and EHR integrations underway, the platform is poised to deliver proactive, workflow-embedded clinical guidance at scale.

In this episode, we speak with Joseph Sokol and Roman Sandler, co-founders of iCardio.ai, about their mission to fully automate echocardiograms using AI. They explain how their two FDA-cleared products - EchoMeasure, which automates over 60 echo measurements, and CardioVision, which screens for aortic stenosis via standard ultrasound - are reshaping cardiac diagnostics by integrating directly into clinical workflows. We discuss the commercial and regulatory lessons learned along the way, and their ambitious roadmap toward a fully autonomous, "self-driving" echo that matches the capabilities of a human cardiologist.

In this episode, we speak with Chris Economos, Senior VP of Business Development at Eko, about how the company is transforming the humble stethoscope into an AI-powered diagnostic platform capable of detecting heart failure, AFib, and structural heart disease. Chris explains how Eko's Core 500 device captures both acoustic and ECG signals to deliver specialist-level insights in 5 to 15 seconds, fitting seamlessly into existing clinical workflows. We discuss the landmark Tricorder study's striking results, Eko's impact in resource-limited settings across Africa, and the company's ambition to put one million AI-enabled stethoscopes into clinicians' hands worldwide.

In this episode, we speak with Dr. Amit Phull, Chief Clinical Experience Officer at Doximity and practicing ER physician, about how the platform serving over 80% of US doctors is approaching healthcare AI. Amit walks us through Doximity's evolution across three eras: from network building to workflow tools to AI-powered solutions like DoximityGPT and Scribe. We discuss their "human in the loop" philosophy, why trust is the key to AI adoption among clinicians burned by past technologies, and how to ensure AI handles administrative burdens while preserving the humanity at the heart of medicine.

In this episode, we speak with Alex Frenkel, clinical psychologist and founder of Kai.ai, about building an AI companion named Kai that delivers mental health support at scale. Alex explains Kai.ai's innovative "two-contact" architecture pairing always-available AI with human clinical oversight, and how the platform avoids the "sycophantic" tendencies of general chatbots by encouraging real-world engagement over digital dependency. We discuss their deployment supporting Ukrainian refugees within days of the war, efficacy data showing 30% improvement in emotional well-being, and the path toward insurance reimbursement and APA certification.

In this episode, we speak with Jim Foote, CEO of First Ascent Biomedical, about functional precision medicine and why testing drugs on a patient’s own tumor cells could transform cancer treatment. Jim explains how their CLIA-certified lab cultures live cancer cells and uses robotics and AI to test hundreds of drug combinations in just 10 days, achieving an 83% correlation with patient outcomes in a Nature Medicine study. We discuss why this approach differs fundamentally from genomic sequencing, hear powerful patient stories, and explore how converging technologies in robotics, AI, and cloud computing have finally made individualized cancer treatment possible at scale.

In this episode, we speak with Henry O'Connell, co-founder and CEO of Canary Speech, about using voice as a biomarker to detect conditions ranging from anxiety and depression to cognitive impairment and autism. He explains how their technology analyzes 12.5 million data elements in 40 seconds of speech, working ambiently during natural conversation to provide clinicians with objective diagnostic insights in real time. We discuss their partnerships with leading medical institutions, integration with Microsoft Dragon Copilot, and their vision for early detection of conditions like ADHD while the brain is still developing.

In this episode, we speak with Pete Durlach, Chief Strategy Officer for Microsoft Healthcare and Life Sciences, about transforming the Nuance acquisition into Dragon Copilot, an AI clinical assistant that combines dictation, ambient intelligence, and generative AI into an extensible platform. Pete explains how Microsoft is creating an "app store" model for healthcare, enabling partners to build plugins for everything from vocal biomarker analysis to clinical decision support. We discuss the expansion into nursing workflows, where 65% report burnout, and why deep EHR integration is essential for AI tools to survive beyond pilot programs.

In this episode, we speak with Susan Tousi, CEO of DELFI Diagnostics and former Chief Commercial Officer at Illumina, about using fragmentomics and AI to detect cancer through a simple blood draw. Susan explains how Delfi's whole-genome approach analyzes the structural chaos of tumor-derived DNA rather than hunting for specific mutations, dramatically reducing cost while maintaining sensitivity. We discuss their first product, First Look Lung, which achieves 75% sensitivity for stage one lung cancer, and how the platform can expand to detect the seven deadliest cancers using the same laboratory workflow with different AI algorithms.

In this episode, we speak with Dr. Thomas Kelly, founder and CEO of Heidi, about building an AI care partner that eliminates administrative burden and restores the physician-patient relationship. Thomas explains how Heidi evolved from an ambient scribe into a comprehensive platform handling documentation, patient communication, and clinical support with a critical focus on personalization that ensures notes match each physician's unique style. We discuss their product-led growth strategy, the ethical boundaries that keep Heidi "clinician allied," and how the company is expanding globally following a $65 million Series B raise.