With the regular season just days away Mina and ESPN's Domonique Foxworth look ahead to the biggest matchups in Week One: Cowboys-Bucs, Browns-Chiefs, Packers-Saints, and Dolphins-Patriots.

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Mina and Charles McDonald of USA Today play Right Call or Wrong Call as they discuss the Patriots' release of Cam Newton, the Bears rolling with Andy Dalton in Week 1, the 49ers' two quarterback system, and Teddy Bridgewater winning the job in Denver.

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The Third Annual Mina Kimes Show Draft returns with Mina and Mike Golic, Jr. drafting all 32 NFL teams, getting deep into the strategy of the game and reviewing last season’s draft. A champion will be crowned based on the following scoring system:

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Mina and ESPN's Field Yates preview the AFC South- How will Urban Meyer 's influence impact the Jaguars' roster (4:45)? How does the uncertainty of the health on the offensive line impact Indy (26:11)? Will the Titans' improved secondary be enough to contend with the Chiefs and Bills (43:03? And what is the new front office doing to turn the tide in Houston (54:51)?

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Mina and Steven Ruiz preview the NFC South- how will Michael Thomas' injury impact the Saints' offense (2:42)? Will Kyle Pitts step into the A.J. Brown role in Arthur Smith's offense (21:30)? Will Sam Darnold take a Ryan Tannehill-esque jump now that he's gotten away from Adam Gase (38:08)? And what, if anything, could potentially derail the Bucs (57:20)?

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Mina and ESPN's Matt Bowen discuss the injuries in Indy and then preview the NFC North including potential pitfalls for the Packers (8:56), why the Lions' offense will be better than people think (21:14), a much improved Vikings defense (47:17), and what the Bears' offense should look like once Justin Fields takes over (53:45).

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Mina and Nate Tice of The Athletic discuss Aaron Rodgers reporting to training camp and then preview the AFC West- What kind of offense will the Chargers run with Joe Lombardi (10:00)? Can the Raiders make up for a shaky secondary (27:02)? Does Patrick Mahomes mask all of Kansas City's holes on defense (44:40)? And is it all about the QB for the Broncos (58:37)?

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Mina and ESPN's Lindsey Thiry preview the NFC West- how will the Rams make up for the loss of Cam Akers (1:02)? When is the right time for the 49ers to turn to Trey Lance (18:29)? Can Kliff Kingsbury finally unlock Kyler Murray (34:08)? And will the Seahawks' defense stand up despite a few glaring holes (45:51)?

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Mina talks to Coach Vass of the Make Defense Great Again podcast about the changing nature of defense in the NFL. Then Roger Bennett stops by to discuss his new book and his fealty to the Chicago Bears.

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Mina and ESPN's Marcel Louis-Jacques preview the AFC East. Can Josh Allen and the Bills' offense replicate what they did in 2020 (1:20)? Will the Patriots defense carry them to the playoffs (19:54)? What will the Dolphins' offense look like with added skill players for Tua (32:39)? And can the Jets front seven make up for their holes in the secondary (48:34)?

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