PGY2 Solid Organ Transplant resident Caroline Simko joins us from the University of Colorado Hospital to discuss “Low-Dose Valganciclovir for Primary Cytomegalovirus Prophylaxis After Heart Transplant: A 10-Year Experience,” along with reflections on her clinical experience counseling identical twins undergoing living donor transplantation without maintenance immunosuppression.

In this episode of mTOR You Know, we share leadership and committee updates from the Transplant PRN business meeting held at the ACCP Annual Meeting in October 2025. Hear from PRN leadership and committee representatives as they reflect on 2025 and outline priorities for 2026.

PGY2 SOT Allyson DeMarco joins us from NewYork-Presbyterian to discuss “Safety of Immunotherapy After Liver Transplantation – A Multicenter Study of a Prospective Standardized Clinical Practice Protocol” (Liver Transplantation 2025), as well as her residency experience managing drug interactions between DOACs and common post-transplant medications.

PGY2 SOT Brooke Aston joins us from the University of Cincinnati Medical Center to discuss “Belatacept Maintenance Immunosuppression for Calcineurin Inhibitor Sparing or Avoidance in Pancreas Transplant Recipients With Progressive Renal or Renal Allograft Dysfunction” (Clinical Transplantation, 2025), as well as her residency experience shadowing in the HLA laboratory to gain firsthand insight into transplant immunogenetics and donor-recipient matching.

For over a decade, the HIV Organ Policy Equity (HOPE) Act has paved the way for transplant centers to accept organs from patients with positive HIV tests for transplant into recipients living with HIV under the research protocol. Earlier this year, following many years of positive outcomes, policy was updated to allow kidney and liver transplant centers to perform these transplants without the need to be under a research IRB. This update has opened doors to organ access for patients with HIV on the waiting list for kidney or liver transplant. Due to this exciting development, hosts Kimberly Leale and Laura Cotiguala are joined by panelists, Drs. Erika Meredith and Lance Lineberger, who have been taking care of abdominal transplants under the HOPE Act for years. In this episode, they provide expert guidance for pharmacists at centers who are looking to start or increase numbers within an HIV positive organ acceptance program under the updated regulations.

Whether you are interviewing for a PGY1, PGY2, or clinical specialist position, you will want to listen to this jam-packed episode of advice from panelists who have experience conduction interviews for all of these positions! Transplant clinical specialists, Drs. Nick Parrish and Rickey Evans, join hosts Lauren, Kim, and Stephanie to discuss anything and everything you have wanted to know about pulling off a successful interview. From prep, to wardrobe, to modern-day follow-up etiquette, we've got you covered!

In this episode of The mTOR You Know, we dive into the evolving role of pharmacogenomics in solid organ transplantation with a focus on tacrolimus andCYP3A5. Our expert panel—Jennifer Trofe, Amy Pasternak, and Shirley Tsunoda—share insights on clinical trial data, guideline perspectives, and real-world application of genotype-guided dosing. We explore the benefits and limitations of CYP3A5 testing, touch on other transplant medications with pharmacogenomic considerations, and discuss barriers such as cost, access, and implementation. The conversation also highlights national survey findings,cost-effectiveness analyses, and strategies for integrating pharmacogenomics into clinical practice.

Literature/Resources mentioned:

• ASERTAA Trial
• Assessing the Utility of a Genotype-Guided Tacrolimus Equation in African American Kidney Transplant Recipients
• Publications discussing benefits of CYP3A5 testing: 1. Anutrakulchai et al, 2. Lloberas et al, 3. Thervet et al
• CPIC® Guideline for Tacrolimus and CYP3A5
• Survey of the utilization of genotype-guided tacrolimus management in United States solid organ transplant centers
• National survey of physicians' perspectives on pharmacogenetic testing in solid organ transplantation
• Stakeholder perspectives of the clinical utility of pharmacogenomic testing in solid organ transplantation
• Cost-benefit analyses of CYP3A5 testing for tacrolimus in transplant recipients: 1. Deininger et al, 2. Pasternak et al, 3. Wang et al,
• Decoding Pharmacogenomic Test Interpretation and Application to Patient Care

In case you missed the live event or would like to revisit the discussion, we are bringing you another opportunity to tune in here! Join moderators Dr. Emily Sartain and Dr. Barrett Crowther as they chat with panelists Dr. Dawn Pluckrose, Dr. Idris Yakubu, Dr. Kayla Joyal, and Dr. Lyndsey Bowman Anger on Mentorship Tips and Tricks. Thank you to the ACCP Txp PRN Programming Committee and the AST Pharmacy COP for bringing us this webinar. All webinars can also be found on the ACCP Transplant PRN YouTube channel.

We’re back with Part 2 of our CMV series! Hosts Aileen Chi and Xena Huang return with the expert panel from the University of Wisconsin—Margaret Jorgenson, Jillian Fose, and Hanna Kleiboeker—to continue the conversation on CMV management in cardiothoracic transplant. In this episode, we explore tricky real-world cases, discuss strategies for managing antiviral resistance, and learn how this team built their renowned CMV stewardship program.

In this episode, we’re bringing you the audio from a recent ACCP joint webinar hosted by the Cardiology and Transplant PRNs—featuring pharmacist-curated highlights from the 2025 ISHLT meeting!

Join Dr. Ian Hollis (UNC Health), Dr. YeeAnn Chen (University of Rochester Medical Center), and Dr. Xena Huang (NewYork-Presbyterian/Columbia) as they break down key takeaways in mechanical circulatory support, heart transplantation, and lung transplantation.

Missed the live session? No worries—we’ve got you covered.