In this episode of The Never Ending Generation, we dive into the radical frontier of age reversal—how Yamanaka factors, a groundbreaking gene therapy pioneered by Nobel laureate Shinya Yamanaka, are being used to reverse aging in mice. We unpack the latest breakthroughs, including partial cellular reprogramming techniques that rejuvenate neurons and muscle tissue without triggering tumors, and explore how AI models like ChatGPT4b are amplifying the power of cellular reprogramming, helping biotech startups like Retro Biosciences engineer more effective Yamanaka cocktails.

You’ll hear how Shift Bioscience’s secretive SB000 gene aims to rival Yamanaka safety, and why Harvard and Life Biosciences are pushing human trials for optic nerve rejuvenation. We also spotlight how senolytics and epigenetic aging clocks are shaping the broader fight against aging. For anyone tracking longevity science, AI‑augmented gene therapy, or the quest for the Fountain of Youth, this episode connects the dots between cutting-edge research, big-name biotech, and the future of human healthspan.