Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: They Don’t Know About Second Booster, published by Zvi on March 31, 2022 on LessWrong.
The FDA went ahead and did it, approving a fourth vaccine shot for those age 50 or older. This is a reference post for those wondering if it makes sense to get that second booster.
The FDA approved the second booster by bypassing some of the normal procedures. Usual never-amused suspects are not amused.
What do those meetings and ‘public discussions’ do?
Delay.
Get picky about lots of little details.
List all the reasons not to do something.
Voice objections for all to see.
Show lots of concern over trivial risks.
The Official Public Health Position is that doing all this Enhances Trust In The Process.
They are incorrect. And here is where their idea of ‘trust’ has gotten us.
Are they working hard on earning our trust back? Not exactly.
Their ‘scientific rationale’ is exactly what you think it is.
None of that means the standard drug process is necessarily bad or worthless. The process is very good at sniffing out any little potentially wrong thing or reason not to do something, and hence good at avoiding false positives. Which is sometimes what you want.
If your goal is to do a cost-benefit analysis to decide what to do, then turning things over to people who think costs and benefits do not belong in the same magisterium, and allowing them to act Deeply Concerned about things, does not seem like The Way.
The process is hopelessly biased towards delay, inaction and risk aversion. It makes sense to bypass it.
Nor does it seem like The Way to get Enhanced Trust. Yes, a few people will say ‘look, you did not hold the Official Meetings’ but actual regular people do not care. If anything, those arguments are crowding out arguments regular people would care about more.
For those shouting from the rooftops that ‘they’ would have us take infinite boosters forever, this is vindication of a sort. Yet it remains not even approved for others, let alone required.
There are good arguments against the second booster. That is fine. We can let individuals make their own choices.
Review: Should You Get a First Booster?
My answer to this continues to be yes.
The original design of the vaccine, of two shots in rapid succession, makes sense if you are trying to quickly test and deploy a vaccine in the middle of a pandemic. Pfizer and Moderna absolutely did the right thing to test that protocol given the situation.
However, there is lots of evidence that spacing the two shots so close together hurts long term immunity. Many vaccines involve much longer times between shots. In the UK, there were debates worrying that some people might not understand the importance of waiting multiple months between shots one and two, because that would make the vaccine less effective. We really, really should have done First Doses First.
Tests reliably show the first booster getting antibody response to levels well above those from the first two shots.
While the full effect of the booster fades over time, there seems to be a persistent and substantial effect on one’s permanent level of immunity.
Thus, even if the short term side effects for you are relatively unpleasant and you are young and in good health, I would get the first booster shot.
If you know you have had Covid-19, that likely functions in many ways as if it were a booster, at which point boosting or not boosting would be a small mistake. I would still boost, and definitely still boost if I was at high risk, but it is no longer obvious.
Should You Get a Second Booster?
The more important question, of course, is: Should you get a second booster?
I want to emphasize that my current viewpoint is that both decisions here are at worst small mistakes.
If you do get a second booster, the costs are minimal, beyond the short term side effects of being knocked on your ...