Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Get Set, Also Go, published by Zvi on December 23, 2021 on LessWrong.
Paxlovid no longer illegal. Excellent. Alas, production will take a while to scale, and right now there are other more pressing concerns.
I thought this week’s headline would be divided over two weeks, but life comes at you fast when cases double every two days instead of every three. I’ve already explained why the CDC Nowcast clearly got ahead of itself and outputted obvious nonsense, which is important for putting together a model, but Omicron is still crossing 50% about now and is well past that in major urban areas.
From this point, predictions get a lot harder, our information sources potentially get a lot less accurate as we run out of testing capacity and (in at least some places) hospital capacity, and reactions become bigger unknowns as well.
I hope to have the Omicron post up by end of day, which will go into my current views on severity (very confusing but looking more promising so far) and spread (which looks less unstoppable thanks to confirming a much lower generation time, I think?) but I haven’t yet had time to sort all of that out and different sources continue to tell different stories.
The immediate, on-the-ground situation is a large jump in cases in many locations, ahead of schedule. This next week is when things potentially get quite bad, and also the first time there’s some chance the graphs mysteriously stop going up for no clear reason, as they did in South Africa and maybe did somewhat in the UK.
I also split off my coverage of the quite bad testing situation into its own post.
Omicron Post #9 will happen later today or failing that tomorrow, but there’s a bunch of developing information and I’m still trying to put it together, so I finished this off first and I’m going to take a break.
Executive Summary
Omicron taking over, cases rising dramatically.
Testing is overloaded, at-homes are hard to find, PCRs are hard to get and slow.
Paxlovid approved but in very short supply for now, Remdesivir study says it too is highly effective.
Let’s run the numbers.
The Numbers
Predictions
Prediction from last week: 862k cases (+15%) and 9,050 deaths (+3%).
Results: 1.03mm cases (+37%) and 9,203 deaths (+4%).
Prediction for next week: 1.85mm cases (+80%) and 10,200 deaths (+10%).
This would be a new record for weekly cases.
Note that my prediction includes substantial discounting for the Christmas break, and for testing overload and testing reluctance (or reluctance to report the results).
We can compare this prediction market, which has us 50/50 to report a record 7-day average by the end of the year. The record used there is 251k cases per day, or 1.75 million, so I’m close to the market value, although I think it’s slightly cheap. Note that they also have the benefit of an extra day.
Last week’s prediction was based on a doubling time of three days. Well, whoops.
Now it gets much harder, because we’re in the adjustment phase and up against the holiday of holidays.
A doubling in one week would be a faster increase than we saw in the UK or in Denmark, but the growth we have seen so far implies far more. Some states did double this past week, while others stayed the same or even declined, because spread is uneven and the United States is large. We’re about to run up against Christmas, with a bunch of people not wanting to get tested right before the holidays and face a quarantine. Others can’t get tested because there aren’t enough tests. Then we’ll face a huge backlog in test processing and reporting. And we don’t know the extent to which behaviors are adjusting, including what happens with Christmas break.
Last year we saw a -20% number for Christmas week, which then bounced back. If there was an avalanche of tests coming in, we might not know until the new year.
So this is the bigge...