Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Omicron Post #6, published by Zvi on December 13, 2021 on LessWrong.
Previous posts: #1, #2, #3, #4, #5, last weekly post
Well, that escalated quickly. Omicron has already escalated quickly in log terms, and will soon escalate quickly in linear terms. The core questions remain the same, and we continue to continuously get better data to allow us to make better guesses and projections.
There are three central places where population-level information is available first:
South Africa, because Omicron has taken over already and they have good data.
Denmark, because they do all the sequencing.
United Kingdom, because of S-gene-deletion data and good sequencing.
We also have a few African countries like Zimbabwe with giant spikes. But in other European countries and in the United States, the lack of sequencing makes it impossible to know how far along things are or how fast they are moving.
Thus, we must rely on what data we have, and give thanks to those who provide it.
Uncertainty abounds but there is no known link between ‘has more Omicron infections’ and ‘has ability and willingness to monitor Omicron cases’ so we should start with the assumption that Denmark and the United Kingdom are typical western countries for this, adjusted for the state of Covid-19 under Delta there relative to other places.
All of that can and should be complemented by experimentation and lab results. Alas, as per usual, challenge trials and most non-natural experiments remain illegal, so we have orders of magnitude less knowledge and certainty from these sources, and everyone is much worse off, than we could if we cared more about saving lives and making people’s lives better and actual ethics, and prioritized those considerations over ‘biomedical ethics.’ So mostly the useful findings lie elsewhere.
Here’s two charts of overall cases and positive test percentages in various places, for context. The rise in Denmark does reflect some Omicron cases, they’d still be under 1,000 on this graph without it, and the UK rise as well.
South Africa
The most hopeful news would be if South African cases peaked all of a sudden for no clear reason, the same way cases of Delta in India did, and started heading downward. We did see a blip for a few days, but was it more than a blip? My read on it is no, and there are signs of issues with data reporting to explain it.
The news on this front is still good, because it’s possible things are improving, and in the worst scenarios things should have continued to get rapidly worse. The positivity rate sticking around 30% would be actively great news.
As you can see on the graph above, the 7-day averages haven’t stopped rising, at least once Our World In Data corrected for temporary data errors. I do still find the lack of a steeper rise to be good news.
Here’s a short explanation of why it’s still too early to draw any conclusions from the death rate. Still need another week or so due to lag.
There are a bunch of threads about South Africa in the Threads section below. They basically all note that a lot of cases continue to be incidental and severity looks low, but that it’s too early to know for sure for reasons I went into on Thursday.
Here’s a video interview with Dr. Angelique Coetzee of the South African Medical Association from December 12. Most optimistic case presented so far. I want to update more but I still don’t feel like this clarifies things much.
Denmark
Denmark has the world’s best sequencing. It also has the largest number of known Omicron cases as a share of population by a lot, which is not a coincidence. And it knows cases are growing exponentially, also not a coincidence.
Here’s an update from yesterday.
Arxiv link.
For speed reasons I didn’t double check the math, but the principles are right and the answer is roughly correct. This is happening,...