The Pain Beat

This 16th episode of The Pain Beat highlights the work of a vibrant consortium of pain researchers working on a project known as Acute to Chronic Pain Signatures (A2CPS). A2CPS is focused on the identification of biomarkers to predict which patients will transition from acute to chronic pain, and which patients living with chronic pain can improve their quality of life with management (see related PRF news story). The Pain Beat invited several Primary Investigators from A2CPS to talk about the work of the consortium, and how listeners of The Pain Beat can get involved themselves!

Podcast participants include:

• Kathleen Sluka, PT, PhD, FAPTA, A2CPS Principal Investigator; University of Iowa, USA
• John Burns, PhD, A2CPS Principal Investigator; Rush University Medical Center, Illinois, USA
• Chad Brummett, MD, A2CPS Principal Investigator; University of Michigan, USA
• Michael Olivier, PhD, A2CPS Principal Investigator; Wake Forest University, North Carolina, USA.
• Stephani Sutherland, PhD, A2CPS Communications Director; Johns Hopkins University, Maryland, USA (moderator)

This 15th episode of The Pain Beat is the third and final of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, PRF related news story here, part one of this series here, and part two of this series here). In this episode, The Pain Beat spoke with a group of collaborators and former mentees to discuss what the discoveries mean for the somatosensory field, as well as stories and insights about what it was like working with Drs. Julius and Patapoutian during that time.

Podcast participants include:

• Allan Basbaum, PhD, FRS, University of California, San Francisco, USA
• Diana Bautista, PhD, University of California, Berkeley, USA
• Alexander Chesler, PhD, National Institutes of Health, Maryland, USA
• Ellen Lumpkin, PhD, University of California, Berkeley, USA
• Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

This 14th episode of The Pain Beat is the second of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, PRF related news story here, and part one of this series here). In this episode, The Pain Beat spoke with Nobel Prize laureate Ardem Patapoutian and Bertrand Coste, Aix-Marseille University, France, to discuss their discovery of mechanically sensitive ion channels – Piezo1 and Piezo2.

Podcast participants include:

• Ardem Patapoutian, PhD, Scripps Research, California, USA
• Bertrand Coste, PhD, Aix-Marseille University, France
• Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

This 13th episode of The Pain Beat is the first of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, and PRF related news story here). In this episode, The Pain Beat spoke with Nobel Prize laureate David Julius and Michael Caterina, Johns Hopkins University School of Medicine, Maryland, USA, to discuss their discovery of TRPV1. The conversation provides insight regarding their thought processes and problem solving, the enduring challenges of scientific discoveries, and the fun they had along the way.

Podcast participants include:

• David Julius, PhD, University of California, San Francisco, USA
• Michael Caterina, MD, PhD, Johns Hopkins School of Medicine, Maryland, USA
• Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

The twelfth episode of The Pain Beat is dedicated to Stephen McMahon, PhD, FMedSci (1954-2021). Stephen, affectionately known as “Mac,” was a world class pain researcher, lecturer, and inspiration to many. Our podcast guests pay homage to “Mac” with stories that illustrate his influence on the pain research field, and those in it. He will be remembered not only for his seminal contributions to our understanding of pain, but also for his generous and enthusiastic personal spirit which has left an indelible mark.

Podcast participants include:

• David Bennett, MB, PhD, University of Oxford, UK
• Gary Lewin, PhD, Max-Delbrück Center for Molecular Medicine, Berlin, Germany
• Irene Tracey, DPhil, University of Oxford, UK
• Franziska Denk, DPhil, King’s College London, UK (Host)

For its eleventh episode, The Pain Beat brought together experts to discuss the biological evolution of nociceptors, their subtypes, and plasticity as part of the Gulf Coast Consortium’s #Pain2021 Webinar Series. These experts study nociceptors across a variety of animal models, including Drosophila, C. elegans, cephalopods, rodents, and humans. The discussion focused on how an evolutionary perspective brings novel insights into the role and function of nociceptors and if, why, and how organisms experience pain.

Podcast participants include:

• Greg Neely, PhD, University of Sydney, Australia
• Edgar T. Walters, PhD, University of Texas Health Science Center at Houston, USA
• Robyn Crook, PhD, San Francisco State University, California, USA
• Ewan St. John Smith, PhD, University of Cambridge, UK
• Ted Price, PhD, University of Texas at Dallas, USA (Moderator)
• Peter Grace, PhD, University of Texas MD Anderson Cancer Center, USA (Host)

For its tenth episode, The Pain Beat brought together guests from a variety of career stages to share their experiences conducting pain and pain-related research during the COVID-19 pandemic. Their discussion highlighted unique and shared experiences, how research priorities and strategies shifted in response to the pandemic, as well as ways in which colleagues found and offered support.  

 

Podcast participants include:

• Theanne Griffith, PhD, University of California, Davis, US
• Kelly Smith, PhD, University of Pittsburgh, US
• Kara Marshall, PhD, Baylor University, Texas, US
• Lindsay Ejoh, PhD Candidate, University of Pennsylvania, US
• Tayler Sheahan, PhD, University of Pittsburgh, US (Moderator)

For its ninth episode, The Pain Beat brought together experts in how pain is measured clinically and experimentally. This multidisciplinary group discussed what is the difference between pain and nociception, why organisms experience pain and whether pain can be objectively measured since it is a subjective experience. Additionally, the group explored why researchers have relied on the measurement of nociception for so long and offer paths forward for the research community including a discussion of new technologies.

 

Podcast participants include:

• Ishmail Abdus-Saboor, PhD, Columbia University, US
• Carl Saab, PhD, Case Western University, US
• Vivianne Tawfik, MD, PhD, Stanford University, US
• Mark Zylka, PhD, University of North Carolina at Chapel Hill, US
• Tayler Sheahan, PhD, University of Pittsburgh, US (Moderator) 

For its eighth episode, The Pain Beat gathered together a group of pain researchers with expertise in the study of sex differences in pain. The group discussed their own discoveries of sex differences in pain in the course of their research, why pain investigators should pay attention to sex differences and how they should go about examining them, and much more.

Podcast participants include:

• Gregory Dussor, PhD, University of Texas at Dallas, US
• Jeffrey Mogil, PhD, McGill University, Montreal, US
• Anne Murphy, PhD, Georgia State University, Atlanta, US
• Kate Sadler, Medical College of Wisconsin, Milwaukee, US (moderator)

For its seventh episode, The Pain Beat gathered together an international group of pain researchers to discuss brain imaging of pain in humans. The podcast focuses on how studies of expectation and the placebo effect have advanced our understanding in this area. What we've learned so far, whether pain brain imaging can be used as a diagnostic tool, and future prospects for neuroimaging are all addressed in this lively discussion.

Podcast participants include:

• Christian Büchel, MD, University Medical Center Hamburg-Eppendorf, Germany
• Irene Tracey, DPhil, University of Oxford, UK
• Tor Wager, PhD, Dartmouth College, Hanover, US
• Howard Fields, MD, PhD, University of California San Francisco, US (moderator)