The Chromogen Siblings are back to talk about TRBC1 IHC in T-cell Lymphomas! Dr. Mike Arnold (@MArnold_PedPath),  Dr. Andrew Bellizzi (@IHC_guy), and Dr. Sanam Loghavi (@sanamloghavi) speak with Dr. Pranav Patwardhan and Dr. Erika Moore of the University of Pittsburgh Medical Center about their publication in the American Journal of Surgical Pathology: The Utility of TRBC1 Immunohistochemistry in the Evaluation of T-Cell Lymphomas.

 Hear about the Hematopathology practice in different institutions, and the challenges in diagnosing T-cell lymphomas. We also hear about how Hematopathologists can use TRBC1 IHC to identify clonal populations of T-cells to support the diagnosis of T-cell lymphoma.

Featured article: 

The Utility of TRBC1 Immunohistochemistry in the Evaluation of T-Cell Lymphomas

https://journals.lww.com/ajsp/abstract/9900/the_utility_of_trbc1_immunohistochemistry_in_the.563.aspx

Featured public domain music: Alpha Hydrae, Won't see it comin'

In this series, PathPod gathers pathologists and trainees Around The Scope to discuss their work in depth.

Today, we hear about prostate pathology and how optimization of Gleason grading can improve prognostic information. Our hosts, Dr. Mike Arnold (@MArnold_PedPath) and Dr. Andrew Bellizzi (@IHC_guy) talk with Dr. Jesse McKenney, Dr. Jane Nguyen (@janenguyen44) and Dr. Sean Williamson (@Williamson_SR) of the Cleveland Clinic.

Hear about how PSA screening changed the biopsies that pathologists see, and how the art and science of re-examining Gleason grading refined prognosis for patients with prostate cancer.

Featured articles:

Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort: https://pubmed.ncbi.nlm.nih.gov/27635949/

Correlation of large cribriform carcinoma and "unfavorable histology" with other Gleason pattern 4 subtypes: A proof-of-principle study evaluating 485 radical prostatectomy specimens with proposal for the concept of "borderline histology": https://pubmed.ncbi.nlm.nih.gov/39644729/

Proposal for an optimised definition of adverse pathology (unfavourable histology) that predicts metastatic risk in prostatic adenocarcinoma independent of grade group and pathological stage: https://pubmed.ncbi.nlm.nih.gov/38828674/

Classification of prostatic adenocarcinoma as favourable/unfavourable histology has high interobserver agreement in prostate needle core biopsies: https://pubmed.ncbi.nlm.nih.gov/40762236/

Public domain music: Main Stem by US Army Blues

In this episode, host Dr. Michael Arnold (@MArnold_PedPath) speaks with Dennis Strenk (@dstrenkpa), Pathologists' Assistant at Wisconsin Diagnostic Laboratories, about the podcast he started in 2019, the People of Pathology podcast. Hear about how he got started as a Pathologists' Assistant and what got him interested in starting the People of Pathology podcast. Hear what he enjoys about podcasting and what he's learned. We also celebrate the 200th episode of the People of Pathology Podcast by listening to a special episode he selected. Hear about what he learned making episode 38 of the podcast, and how the connection he made with his guest, Dr. Ralph Hruban, continued in person.  

You can read more about Dennis Strenk and the People of Pathology Podcast in his recent profile in The Pathologist magazine.

Featured public domain music: Main Stem by US Army Blues

In this series, PathPod gathers pathologists and trainees Around The Scope to discuss their work in depth.

Today, we hear about social media, from #PathArt to TikTok. Our hosts, Dr. Sara Jiang (@Sara_Jiang) and Dr. Mike Arnold (@MArnold_PedPath) speak with Dr. Meredith Herman (X: @MeredithKHerman TikTok: @meredithkherman) and Julia Kochanowski (TikTok: @myforensicpath) about now pathology and medical education on social media is changing. Hear about how they create for social media, from videos to #PathArt, the connections they've made on social media and how their interactions are helping change perceptions about pathology.

Public domain music: Main Stem by US Army Blues

The Chromogen Siblings return to talk about small cell lung carcinomas. Drs. Mike Arnold (@MArnold_PedPath),  Andrew Bellizzi (@IHC_guy), and Sanam Loghavi (@sanamloghavi) speak with Dr. Natasha Rekhtman (@natasharekhtman) of Memorial Sloan Kettering Cancer Center. Hear about how Pathologists use IHC to identify subsets of small cell lung carcinomas, and the cycle of how molecular data informs IHC approaches and histologic classifications in Pathology.

Featured articles: 

SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization

https://www.jto.org/article/S1556-0864(20)30755-3/fulltext

POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC

https://linkinghub.elsevier.com/retrieve/pii/S1556-0864(22)00299-4

Featured public domain music: Alpha Hydrae, Won't see it comin'

In this segment, Beyond the Scope, we speak to pathologists about their pursuits and interests in and outside of pathology.

Links to papers referenced in the episode:

In this episode, we celebrate PathPod's 5th Birthday by listening back to the first ever PathPod Quiz Show from April 30, 2020.

Happy Birthday PathPod!

In this edition of IHC Talk, Dr. Mike Arnold (@MArnold_PedPath), Dr. Andrew Bellizzi (@IHC_guy), and Dr. Sanam Loghavi (@sanamloghavi) delve into the exciting (and sometimes intimidating!) world of Artificial Intelligence and its potential to revolutionize pathology. They're joined by special guest Dr. Matt Cecchini (@Path_Matt), a pathologist with a keen interest in AI.

What you'll discover:

Get ready for a lively discussion that covers everything from image analysis and mitigating bias to AI agents. The crew dives deep into real-world examples, current tools like ChatGPT, and even the ethical considerations as AI takes on more responsibilities in diagnostic settings. Is AI about to replace pathologists, or can it augment our abilities to deliver better patient care? Listen in and explore the possibilities with this engaging episode!

Thanks to Dr. Cecchini for using Gemini to generate this episode description, and ChatGPT to generate the cover art!

Featured public domain music: Alpha Hydrae, Won't see it comin'.

The Chromogen Siblings are back to talk about soft tissue sarcoma diagnosis and classification. Drs. Mike Arnold (@MArnold_PedPath),  Andrew Bellizzi (@IHC_guy), and Sanam Loghavi (@sanamloghavi) speak with Dr. David Papke of Harvard University. Hear about his work and thoughts on identifying new diagnostic entities in soft tissue pathology. We also hear his remembrance of the late Dr. Christopher Fletcher and the influence Dr. Fletcher had on his career and the field of soft tissue pathology.

Featured public domain music: Alpha Hydrae, Won't see it comin'.

In this episode, Dr. Margaret Collins of Cincinnati Children's Hospital speaks hosts Dr. Jason Wang and Dr. Michael Arnold (@MArnold_PedPath) about the Pediatric and Developmental Pathology Podcast. Hear about the journal Pediatric and Developmental Pathology, and what makes it unique. We also listen back to the first episode of the Pediatric and Developmental Pathology Podcast, featuring a conversation about the article co-authored by Dr. Collins, Eosinophilic Gastrointestinal Disorders: A New Path.

Featured public domain music: Main Stem by US Army Blues