Paul stands in the synagogue at Pisidian Antioch and traces Israel's story from the Exodus through David to show that the Old Testament promises find their fulfillment in Jesus. He proclaims that through Jesus forgiveness of sins and justification are now offered to all who believe.

The sermon calls for faith and warns scoffers, sparks both eager response and opposition, and marks the turning of the gospel outward to the Gentiles as the message begins to spread across the region.