Dr Marwan Bukhari speaks to Prof Yoshiya Tanaka, University of Occupational and Environmental Health, Japan, about his recent paper on strategic treatment of PsA patients according to phenotypic differences in helper T cells. They highlight the benefits of using precision medicine to treat PsA, with significantly higher efficacy observed in this study than in standard bDMARD therapy. They discuss the potential next steps for precision medicine in other diseases and new drugs becoming available for treatment.