The Sci-Files on Impact 89FM

Chelsie and Daniel visited the COGS Graduate Academic Conference (GAC) for the last time. They continued to interview students briefly about their research. Listen to them speak with Jamily Ramos De Lima and Betul Kara.
If you want to discuss your MSU research on the radio or nominate a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube! 

Chelsie and Daniel visit the COGS Graduate Academic Conference (GAC) for the last time. They interviewed students briefly about their research. Listen to them speak with Debkumar Debnath, Sam Weiser and Daniel Marri. This will be a three-part series as Daniel and Chelsie say bye and welcome the new hosts of The Sci-Files soon. 
If you’re interested in discussing your MSU research on the radio or nominating a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube! 

On this week’s The Sci-Files, your hosts Chelsie and Danny interview Brett Volment. Heart diseases represent the leading causes of death worldwide. Researchers commonly use cellular and animal models to investigate and study cardiovascular disease and other diseases. However, these models do not provide the best representation of human physiology. To this end, Brett’s work focuses on growing and creating miniature 3D human hearts, termed “heart organoids” that allow more faithful insight toward heart development, disease mechanisms and effective treatments for heart disease. Brett creates these mini hearts using human stem cells and mimics the environment present in the fetus to advance their maturity. In doing so, he elicits 3D hearts with all major cell types found in the human heart, internal chambers representing atria and ventricles, and a dynamic vessel network. This system represents a powerful tool that researchers can use to investigate human heart development and to screen for disease therapeutics, and ultimately, serves as a major stepping stone towards generating fully synthetic human hearts from stem cells.

If you’re interested in talking about your MSU research on the radio or nominating a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube!

On this week’s The Sci-Files, your hosts Chelsie and Danny interview Joshua Kaste. Joshua is a Ph.D. Candidate in the Department of Biochemistry and Molecular Biology at Michigan State University, and he works in the Shachar-Hill laboratory. His work focuses on building and analyzing mathematical models that describe the rates of all the chemical reactions going on in a living cell or whole organism. If you think of all the chemical compounds and the chemical reactions between them as a sort of road map, these models are like the traffic heat map showing where there's congestion, where there's not much activity, etc. This kind of work gets used for basic biological research, but it can also be used by biological engineers since a lot of projects require modifying an organism so that it makes more of a chemical compound. This kind of analysis can be very helpful for figuring out how exactly to accomplish that. In particular, Joshua’s work focuses on the oilseed crop Camelina sativa, which is cultivated for its oil, which can be used as fuel. By modeling its metabolism, we may be able to improve the oil yield farmers get from it, improving its viability as an alternative to fossil fuels.
If you’re interested in talking about your MSU research on the radio or nominating a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube! 

On this week’s The Sci-Files, your hosts, Chelsie and Danny, interview Jamell Dacon. Jamell is the MSU Department of Computer Science and Engineering. His current research focuses on fairness and bias in Natural Language Processing (NLP). Because inclusivity matters in all forms. He intends to investigate, examine and mitigate societal biases to conceptualize the "isms" that plague our society via NLP technologies to increase social justice and reduce feelings of disenfranchisement. Specifically, he focuses on conceptualizing social harms arising from the advancements in language technologies, highlighting both positive and negative societal impacts.
If you’re interested in discussing your MSU research on the radio or nominating a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube! 

On this week’s The Sci-Files, your hosts, Chelsie and Danny interview Emily Greeson. Emily works in the Microbiology and Molecular Genetics department in the Contag lab at Michigan State University. Her work focuses on studying and engineering genes in bacteria to create new functions. Recently, Emily has been working on Bacillus subtilis, a soil bacterium, and adding temperature-sensitive repressors to it to control protein production. Temperature-sensitive repressors respond to changes in temperature by stopping protein production at lower temperatures and allowing proteins to be produced at higher temperatures. The Contag lab has taken the bacteria with these temperature-sensitive repressors one step further and combined them with magnetic nanoparticles and electromagnetic fields to create a new system. After graduation, Emily hopes to focus more on science communication and education, including working at the MSU Museum CoLab Studio in the 1.5 Celsius exhibition.
If you’re interested in discussing your MSU research on the radio or nominating a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube! 

On this week’s The Sci-Files, your hosts, Chelsie and Danny interview Hariharan Ramakrishnan. Cisplatin is an incredibly powerful chemotherapy drug used to treat a variety of cancers. However, its side effects, such as kidney toxicity and painful neuropathy, may result in dose reduction or termination of treatment increasing patient mortality. Physicians must closely monitor the patient’s kidney function during chemotherapy due to the high risk of kidney failure, and the patient’s sensitivity, due to severe pain from peripheral neuropathy. Therefore, there is an urgent medical need for novel therapeutics that limit cisplatin’s side effects. Adenosine receptors are involved in several kidney diseases and neuropathic pain pathophysiology. Hari hypothesizes that blocking adenosine receptors (AR) using Istradefylline, an FDA-approved AR antagonist will alleviate kidney toxicity and pain from cisplatin. He found that administering Istradefylline reduces both the pain hypersensitivity and kidney toxicity induced by cisplatin and the associated inflammation. Since the FDA already approves Istradefylline for treating Parkinson’s disease, it can be quickly clinically applied to cancer therapy. You can learn more about the Laumet lab's research at their website.
If you’re interested in discussing your MSU research on the radio or nominating a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube! 

On this week’s The Sci-Files, your hosts Chelsie and Danny interview Anna Kim and Roksana Riddle. The United States CDC estimates 2.8 million drug-resistant infections resulting in 35,000 deaths yearly. Pseudomonads are amongst the most resistant to antimicrobials, not only in clinical settings but equally in plant systems like P. syringae. P. syringae is a causative agent for multiple diseases affecting nearly all major economic crops worldwide. Despite the yearly rising numbers of drug-resistant infections, common treatments include antibiotics. Drug-resistant microbes have sparked renewed interest in bacteriophage use in plant infections. Bacteriophages, or phages, are natural predators of bacteria, using them as a host to reproduce. Due to phage's high-host specificity and ability to kill microbes efficiently, the use of phages as a plant biocontrol has increasingly been studied with the rise of drug-resistant microbes. The application of phage on crops results in decreased phage viability due to varied environmental conditions, including UV and pH levels. Check out more about their project here.
If you’re interested in discussing your MSU research on the radio or nominating a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube! 

On this week’s The Sci-Files, your hosts Chelsie and Danny interview Sam Barans. Sam researches patient histories of trauma in populations at Clinical High Risk for psychosis at the University of New Mexico. With estimates of trauma exposure ranging from 54 to 97% in this population, it's important to identify trauma risk factors and focus treatment on patients' history of trauma. Sam's research aims to identify discrepancies between patient self-reports of trauma and clinician reports of Adverse Childhood Experiences.
If you’re interested in discussing your MSU research on the radio or nominating a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube! 

On this week’s SciFiles, your hosts Chelsie and Daniel interview Jamie Liebold. Zahra is a senior studying Comparative Cultures and Politics with Minors in Global Public Health and Epidemiology and Computational Math, Science, and Engineering. Aware of the racial bias in police use of force, Zahra's research focuses on the impact police administrative policy can have on police behavior, especially regarding police use of force. This episode will look at the situation of the State of Michigan in terms of the level of transparency of these policies, what this means, and where to go from there. Please see 8cantwait.org if you want to learn more about the policy reforms that inspired the research!
If you’re interested in talking about your MSU research on the radio or nominating a student, please email Chelsie and Danny at [email protected]. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube!