Where is most of the universe? And why don't we know yet? Yes—we’re talking about dark matter and dark energy, the mysterious stuff that’s predicted by physical theory, but which still remains elusive in experiments.

After speaking to an actual physicist, Tom and Stuart attempt to explain what dark matter and dark energy are supposed to be, and what physicists would have to see in their experiments to know that they exist. They also come down with a serious case of physics envy.

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The Studies Show is sponsored by Works in Progress magazine, which has just published this excellent new article on the history of French nuclear power. Why has France been so successful at building nuclear plants while other countries have dropped the (radioactive, probably flourescent green) ball? “Liberté, Egalité, Radioactivité” tells you everything you need to know. Find it and much more, all for free, at worksinprogress.co.

• August 2025 Science article about a “big blob” of dark matter in the Milky Way

• LIGHTS ALL ASKEW IN THE HEAVENS

• Cosmic microwave background? Or pigeon droppings?

• 1984 Nature paper about “cold dark matter” and the formation of galaxies

• WMAP probe map of the cosmic microwave background

• Two papers from 1998 on the accelerating expansion of the universe

We’re very grateful to Prof. Andrew Pontzen of Durham University for talking to us for this episode (all mistakes are our own). The Studies Show is produced by Julian Mayers at Yada Yada Productions.

In our last standard episode, we talked about retraction—removing papers from the scientific literature. Well, it turns out there’s an awful lot of retraction to do, in large part due to paper mills. These are fraudulent enterprises that take money from nefarious scientists to put their name on fake scientific papers, and get them published in whatever journal will accept them. Sadly, paper mill papers are now rife.

In this solo episode of The Studies Show (Tom is away at a wedding), Stuart talks through a new paper showing just how badly these paper mills have poisoned the scientific literature.

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• The new PNAS paper using various techniques to examine coordinated attempts at scientific fraud

• A response from PLOS

• The Retraction Watch article on ARDA

• A few interesting recent articles on paper mills

• The Nature News article on the universities with the most retractions

• AI versus paper mills

The Studies Show is produced by Julian Mayers at Yada Yada Productions.

Internet users in the UK recently found they couldn’t access an awful lot of the internet without either having their faces scanned or providing a credit card or legal ID. That’s because the 2023 “Online Safety Act” is steadily coming into force.

Tom interviews two people who know about it – Pete Etchells of Bath Spa University and Andrew Przybylski of t…

We’re very sorry about the disrupted service over this summer! It’s been hectic with work and a house move and various things. To tide you over, here’s a formerly paywalled episode: our very first one.

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If you’ve ever done a diversity training session at work, you’ll almost certainly have learned about unconscious bias, microaggressions, stereotype threat, and trigger warnings. Prejudice, racism, and trauma are apparently simmering constantly, just under the surface of our conscious minds.

It turns out that each of these concepts has been subject to a lot of scientific research. It also turns out, perhaps unsurprisingly, that they’re all extremely controversial. In this first paid-subscriber-only episode of The Studies Show, Tom and Stuart look at each of them in turn and try to decide which of them—if any—stand up to scrutiny.

To listen to the full version of this episode and see the show notes, you’ll need to be a paid subscriber to The Studies Show podcast on Substack. See below, or go to www.thestudiesshowpod.com/subscribe, for the options.

If you’re already a paid subscriber: thank you!

• Unconscious bias:

  • The Implicit Association Test at Harvard

  • The 2019 meta-analysis on experiments that try to change implicit, explicit, and behavioural biases

  • Article by Patrick Forscher, meta-analysis co-author, on unconscious bias training in CapX

  • Equality & Human Rights Commission Report on unconscious bias training

• Microaggressions:

  • Original 2007 American Psychologist paper on microaggressions

  • Scott Lilienfeld’s 2017 critique of microaggression research

  • His article in Aeon summarising the critique

  • Response to Lilienfeld by Monnica Williams

  • Lilienfeld’s reply to Williams

• Stereotype threat:

  • In the UK, girls now do better than boys at maths

  • 2015 meta-analysis on sex-related stereotype threat for maths

  • 2018 follow-up study by the same authors

  • 2019 meta-analysis on sex- and race-related stereotype threat

  • Planned meta-analysis on the decline effect in stereotype threat research

• Trigger warnings:

  • The 2023 meta-analysis on trigger warning research

  • Scott Alexander on “The Wonderful Thing About Triggers”

  • Jonathan Haidt and Greg Lukianoff’s book The Coddling of the American Mind

The Studies Show is produced by Julian Mayers at Yada Yada Productions.

RETRACTED // In this episode of The Studies Show, Tom and Stuart discuss retraction, the process of removing articles from the scientific record. How often is it due to fraud? How many papers get retracted—and is the number increasing? Is it good or bad for a scientist to retract an article? // RETRACTED

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Want even more podcasts? Now our sponsor, Works in Progress magazine, has a podcast where their editors talk to people with interesting progress-related ideas. One such person is the historian Anton Howes, who is interviewed about the unexpected origins of the Industrial Revolution in the latest episode. Find it at worksinprogress.news.

• Retraction Watch, the extremely useful website that tracks and investigates retractions

• Science’s writeup of the long process of retracting the GFAJ-1 “arsenic bacteria” paper

  • Original paper; retraction note; response from the authors

• The first known retraction, from 1755

  • Retraction Watch’s discussion of it

• Adam Marcus and Ivan Oransky on tracking retractions over time

• 2022 PLOS ONE article on the number of retractions over time

• Scholarly Kitchen post on the rate of retractions over time

• Nature article on the 10,000 retractions in 2023 alone

• 2011 article on the causes of retractions

  • 2012 article on the same: misconduct is found to account for the biggest proportion

• James Heathers on the disastrous story of Wiley buying Hindawi

• The retraction guidelines from COPE

• The paper with a diagram of a very well-endowed rat

• Are authors punished for retractions? Not necessarily

• Reputational advantage from correcting errors

• 2022 article on how scientists still regularly cite retracted papers (without knowing they’re retracted)

We’re very grateful to Ivan Oransky from Retraction Watch for his help with this episode. Any mistakes are ours. The Studies Show is produced by Julian Mayers at Yada Yada Productions.

Pay attention. Focus on your breathing. Live in the moment. Accept yourself. Do you have a self? Focus on that self. And so on. This is, of course, the practice of mindfulness meditation, which seems to be everywhere: in schools, at work, in apps, and all over the scientific literature.

Do any of the claimed effects of mindfulness meditation (relieving your depression! Changing the structure of your brain!) actually add up? In this episode of The Studies Show, Tom and Stuart focus calmly, serenely, and gratefully on their own thoughts, and then find out.

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The Studies Show is brought to you by Works in Progress magazine. WiP has started doing its own podcasts! Don’t worry—we give you permission to listen to them. The one we mentioned on the show this week is an interview with Stian Westlake, the extremely interesting Chief Executive of the UK’s Economic and Social Research Council and expert in the “intangible” economy.

• When Sam Harris tried to get Richard Dawkins to meditate on a podcast

• Tom’s 2014 article on mindfulness, before all the criticisms started appearing

• Mindfulness tips from the NHS

• The 2017 critical paper from Perspectives on Psychological Science

• 2014 meta-analysis finding no effect beyond active controls

• 2021 meta-analysis drawing a similar conclusion

• The now-retracted 2023 Scientific Reports meta-analysis on mindfulness and brain structure

  • Eiko Fried’s article discussing his experience critiquing the paper

  • The eventual retraction note

• PLOS ONE paper from 2016 on the number of positive results found in mindfulness trials

• 2015 meta-analysis on mindfulness in healthcare

  • The eventual retraction note

• 2022 writeup of the MYRIAD study of school-based mindfulness techniques

  • Critical opinion piece by a mindfulness sceptic

• Study on mindfulness in the context of neoliberal capitalism

The Studies Show is produced by Julian Mayers at Yada Yada Productions.

Are cancer rates going up or down? It seems like depending on where you look, you’ll find different answers to the question. What’s going on here — have some writers just got it completely wrong? Is it something to do with different types of cancer? Are we being confused by some kind of weird statistical artefact? All of the above? In this episode of The Studies Show, we do our very best to find out.

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The Studies Show is brought to you by Works in Progress magazine, the ultimate place online to read about new and underrated scientific and technological ideas that could make the world a better place. You can find a huge range of essays online, for free, at www.worksinprogress.co.

• BBC Future article on early-onset cancer rates

  • BMJ Oncology article on global cancer incidence increasing by 79%

    • And its online supplementary information

• July 2025 Economist article on how the world is winning the war on cancer

• Saloni Dattani’s 2025 article on the decline in global cancer rates

• The GLOBOCAN data update from the IARC, 2002 and 2008

• Our World in Data’s graph on global cancer incidence over time

  • Their graph on smoking rates and lung cancer deaths

  • Their graph on stomach cancer death rates

• New RCT on vaping and smoking cessation

• A 90% drop in cervical cancer rates in England

• The hepatitis B vaccine and a massive drop in liver cancer incidence in China

• On H. pylorii, ulcers, and cancer

• 2000 JAMA article questioning the utility of the 5-year survival rate statistic

  • 2014 PLOS ONE article that’s more positive about the statistic

• Tom’s BuzzFeed News article on oncology

• RCT of herceptin on breast cancer survival

• Study on rates of colorectal cancer

  • And the same, in relation to BMI

The Studies Show is produced by Julian Mayers at Yada Yada Productions.

Seconds out! Round one! Ding ding! And other boxing terms. We’ve found a topic on which Tom and Stuart actually disagree. Kind of. In this episode of The Studies Show, they use the examples of “the worm wars” (does deworming kids in developing countries help them stay in school?) and a new craze for “tooth bacteria” (can colonizing your mouth with a genetically-modified bacterium stop you getting cavities?) to argue about how we should make our minds up about uncertain—but potentially promising—medical treatments.

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The Studies Show is brought to you by Works in Progress magazine. On the show this week we discuss one of the articles in their newest issue, on “the end of lead”—the history of countries slowly removing lead from pipes, paint, and the rest, and how much work still needs to be done. Find it, and a wealth of other fascinating free articles, at worksinprogress.co.

• Tom’s Unherd article about the Worm Wars

• The famous 2004 paper that sparked the wars

• “Deworming Debunked”, from the BMJ

• The 2014 follow-up of the original dewormed Kenyan kids

• GiveWell’s re-analysis of both studies

  • And another more recent analysis by the same org

• The third study in the same kids, from 2020

• 2019 paper on “resolving the worm wars”

• Scott Alexander’s article on “defying cavity”—on the Lumina bacteria

• Guy who claims the Lumina bacteria made him go blind

• Saloni Dattani’s useful thread on Lumina

• 90% of drugs in preclinical trials don’t make it to become medicine

• Tom’s frankly cruel tweet where he refers to Stuart as “Goofus”

The Studies Show is produced by Julian Mayers at Yada Yada Productions.

Inspired by a new Nature paper on how the “maths gap” emerges between girls and boys in school, Tom and Stuart look into the evidence for psychological sex differences: in maths, in mental rotation, and, yes—in whether they like pink or blue.

To listen to the full episode and read the show notes, you’ll need to become a paid subscriber at www.thestudiesshowpod.com/subscribe.

Whether it’s people giving themselves goat blood transfusions in an effort to maintain their youth, or yet another influencer telling you to buy XYZ miracle supplements, anti-ageing is big business.

In the first part of what will surely become a longer Studies Show series, Tom and Stuart look at the evidence for a few supposed “breakthrough” treatments that can slow down ageing: rapamycin, metformin, winding back the epigenetic clock, and calorie restriction.

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The Studies Show is brought to you by Works in Progress magazine. This week we talked about their new article on “through running”—the deceptively simple idea of not having trains stop at the edge of town and instead running them right through the centre. It seems obvious if you live in London, but it wasn’t always this way. Check out the article for a detailed, nerdy discussion about how we can make trains—and therefore citites—better.

• New meta-analysis on rapamycin and ageing

• Website for Bryan “n = 1” Johnson and his related health claims

• Our World In Data on life expectancy and about the reasons why it increased

• Meta-analysis on methylation and the “biological clock” as a predictor of longevity

• The STAP stem cell debacle

• 2016 study using Yamanaka factors to slow down ageing in mice

• 2023 study of the same idea on wild-type mice, showing a 109% increase in life expectancy

• 2014 Scottish study on diabetes, metformin, and life expectancy

  • Critical letter noting the study’s flaws

  • Failed replication from Denmark in 2022

• The NIH’s Interventions Testing Program

• Older review of calorie restriction and ageing

We’re grateful to Andrew Steele for talking to us for this episode. The Studies Show is produced by Julian Mayers at Yada Yada Productions.