Dive into the remarkable world of peptides with Dr. Ethan in this enlightening episode of "The Science of Age-less Living." While BPC-157 and TB-500 often steal the spotlight, we'll uncover the hidden potential of KPV and VIP—two lesser-known peptides that hold incredible promise for healing and regeneration. Discover how KPV acts as an anti-inflammatory powerhouse, promoting gut health, while VIP serves as a multi-system modulator affecting everything from the brain to the immune system. Join us as we explore the science behind these game-changing compounds and their therapeutic applications. Like this video and share your thoughts in the comments below!

OUTLINE:

00:00:00 Welcome to The Science of Age-less Living

00:00:37 Shifting the Spotlight to KPV and VIP

00:01:02 What to Expect in This Episode

00:01:16 The Limitations of Popular Peptides

00:01:48 The "Poster Children" of Peptide Therapy

00:02:03 The Deeper Benefits of Peptides

00:02:22 The Unsung Heroes

00:02:38 KPV – The Anti-Inflammatory Powerhouse

00:02:56 Origin and Mechanism of KPV

00:03:26 How KPV Works in the Body

00:03:47 KPV in Simpler Terms

00:04:01 Clinical Relevance of KPV

00:04:24 KPV and Gut Health

00:04:55 KPV and BPC-157

00:05:04 KPV’s Expanding Role

00:05:28 Current Research on KPV

00:05:50 Anecdotal and Clinical Use of KPV

00:06:28 KPV Tolerance and Safety

00:06:34 What KPV Represents in Medicine

00:06:50 VIP – Vasoactive Intestinal Peptide

00:06:58 What VIP Is

00:07:18 VIP is More Than a Vascular Regulator

00:08:01 VIP Effects on Inflammation

00:08:18 VIP and Circadian Rhythm

00:08:36 VIP Neurons and Biological Clocks

00:08:47 Clinical Applications of VIP

00:09:25 VIP Influences Brain-Gut Communication

00:09:57 Human Trials for VIP

00:10:10 Anecdotal Use of VIP

00:10:30 VIP is a Double-Edged Sword

00:10:50 VIP is Promising for Homeostasis

00:11:06 Why Aren’t KPV and VIP More Well-Known?

00:11:12 Market Dynamics and Visibility

00:11:35 KPV and VIP Act Quietly

00:11:46 Complexity of Administration

00:11:58 KPV and Marketing Limitations

00:12:06 Access and Regulation Challenges

00:12:21 Hidden Gems of Peptide Therapy

00:12:30 The Future of KPV and VIP

00:12:33 Rise in Studies and Research

00:12:46 Cornerstones of Repair

00:12:56 VIP Could Emerge as a Leading Therapy

00:13:06 Imagine a Future with Peptide Therapy

00:13:24 Consult a Healthcare Provider First

00:13:36 Stay Curious – The Field is Evolving

00:13:44 KPV – The Quiet Powerhouse

00:13:56 VIP – The Multi-System Modulator

00:14:06 The Next Evolution in Peptide Therapy

00:14:13 Reach Out and Connect

00:14:30 Subscribe for More Longevity Science

00:14:54 Stay Curious, Stay Vital, Live Age-lessly

Dr. Ethan breaks down epigenetics and how your daily choices shape biological age in this 19:45 deep-dive. Learn DNA methylation, histone modification, non-coding RNAs, epigenetic drift, methylation clocks (Horvath, GrimAge), and practical lifestyle levers—nutrition, exercise, sleep, stress management, and environmental hygiene—to “rewrite” your cellular code. Explore cutting-edge therapies like peptides, NAD+ micro-dosing, senolytics, and partial reprogramming, plus consumer methylation tests and future epigenetic editing. Perfect for health-conscious adults 35+ seeking science-backed longevity strategies and actionable tips. If this episode helped, please like and share with someone you care about. Visit The Catalyst Clinic for more resources.

Dr. Ethan breaks down how peptide therapy is transforming perimenopause care—targeting hormone balance, mitochondrial function, inflammation, sleep, cognition, libido, and metabolic health. This 38:15 deep-dive covers Epitalon, DSIP, Semax, Selank, Kisspeptin-10, CJC-1295 + Ipamorelin, PT-141, BPC-157, Thymosin Alpha-1, NAD+ support, and practical protocols used at The Catalyst Clinic. If you’re a woman 35–55 navigating perimenopause, learn precision approaches to reduce brain fog, restore energy, protect bone and muscle, and optimize long-term health. Like and share if you found this helpful—help other women discover science-led options for thriving through midlife. #Perimenopause #PeptideTherapy #Longevity #WomensHealth #Mitochondria

00:00:00 Opening

00:02:04 Differentiating Perimenopause

00:03:46 Cellular Mechanisms

00:06:54 Peptides 101

00:09:15 Mechanisms and Examples

00:13:30 Categories and Protocols

00:18:18 Sexual Health and Energy; Inflammation and Longevity

00:21:35 Synergistic Protocols

00:23:43 Evidence

00:28:14 Case Studies

00:30:59 Risks, Ethics, and Regulation

00:35:55 Sum Up

Summary: The Science of Age-less Living — The Promise of Senolytics

In this episode, Dr. Ethan Hausman-Marquis, cosmetic surgeon, professor, and founder of The Catalyst Clinic, explores one of the most exciting frontiers in longevity medicine: senolytics—therapies designed to selectively eliminate aged, dysfunctional “zombie cells” that accumulate in our bodies as we age.

OUTLINE:

00:00:00 Introduction and Credentials

00:01:15 Scientific Foundation

00:02:13 Understanding Senescent Cells

00:06:14 Senolytics Introduction

00:10:12 Clinical Evidence

00:14:33 Cosmetic and Regenerative Applications

00:17:58 Ethical and Regulatory Considerations

00:21:20 Future Outlook

00:23:14 Conclusion and Wrap-up

Dr. Hausman-Marquis explains how these senescent cells, far from being harmless bystanders, actively contribute to inflammation, tissue breakdown, and many hallmarks of aging, from sagging skin to chronic disease. Senolytics, including natural compounds like fisetin and pharmaceutical agents like dasatinib, are at the cutting edge of research, showing early promise in improving physical function, reducing inflammation, and possibly even reversing aspects of age-related decline.

The episode breaks down:

• What senescent cells are, why they matter, and how they undermine our health
• How senolytic therapies work to clear out these dysfunctional cells
• The latest research findings, including animal and early human clinical trials
• The potential synergy between senolytics and regenerative treatments in aesthetics, hair restoration, and orthopedics
• The ethical, regulatory, and safety considerations as this field rapidly evolves

With a focus on both the scientific promise and the need for caution, Dr. Hausman-Marquis envisions a future where personalized senolytic therapies become a cornerstone of age-less living—helping not just to add years to life, but vitality and quality to those years.

Tune in to learn how clearing out cellular clutter could be the key to unlocking a healthier, more vibrant future.

Dive into polygenic risk scores (PRS) and discover how your genetic blueprint can inform personalized longevity strategies. Dr. Ethan Hausman-Marquis breaks down genome sequencing, five major genetic pathways to aging (DNA repair, metabolism, inflammation, mitochondria, neurodegeneration), and real-world clinical applications from The Catalyst Clinic.

Learn how PRS can shift prevention from one-size-fits-all to truly individualized interventions—while understanding limits like population bias and probabilistic risk. Perfect for longevity science fans curious about precision medicine, NAD+, peptides, and building cognitive and mitochondrial resilience. If this episode helped you, please like and share with someone interested in age-less living. #PolygenicRiskScore #Longevity #PrecisionMedicine #AntiAging #Genomics

OUTLINE:

00:00:00 Title and Introduction

00:02:35 Genes Aren't Destiny

00:06:19 What Is a Polygenic Risk Score?

00:10:28 Two Patients Example

00:13:17 Five Major Pathways

00:20:58 Limitations and Caveats

00:25:30 Clinical Application

00:27:56 Emotional Impact

00:29:58 Closing Reflection

Join Dr. Ethan as he delves into the science of Retatrutide, a groundbreaking synthetic peptide developed by Eli Lilly.

This episode unpacks how Retatrutide targets three key hormone receptors—GLP-1, GIP, and glucagon—revolutionizing approaches to weight management, glucose regulation, and metabolic health. Explore the molecular biology, receptor targets, and clinical trial results that set Retatrutide apart from drugs like Semaglutide (Ozempic) and Tirzepatide (Mounjaro). Whether you’re a clinician, student, or just curious about the future of obesity and diabetes treatment, this accessible overview illuminates the intersection of chemistry, biology, and innovative drug design. Like and share this video if you want to stay updated on leading-edge metabolic research!

#Retatrutide #MetabolicHealth #ObesityTreatment #Diabetes #MolecularBiology #WeightLoss #MedicalInnovation

In this episode of The Science of Age-less Living, Dr. Ethan—doctor, molecular biologist, athlete, and regenerative medicine expert—explores the fascinating world of peptides and their essential role in cellular health, performance, and longevity. This episode demystifies peptides, describing them as short chains of amino acids that function as “project managers” within our cells. Using engaging construction site analogies, Dr. Ethan explains how peptides are created from DNA instructions, undergo precise modifications, and are tightly regulated to perform specific tasks. Unlike proteins, peptides are shorter and act mainly as messengers and coordinators, directing when and how cells grow, heal, and defend themselves.Listeners learn about:

• The biological processes of transcription and translation, which turn DNA blueprints into peptide messengers.
• How peptides signal, regulate, and coordinate vital cellular functions—like hormone release, tissue repair, and immune defense.
• The dynamic regulation, modification, and recycling of peptides, and their impact on age-related health and disease.
• The expanding potential of peptide-based medicine, from anti-aging therapies to immune boosters.

Dr. Ethan concludes by emphasizing the adaptability and responsiveness of the body’s peptide system, inspiring listeners to make informed, proactive choices to support their own health and longevity. The episode encourages curiosity, self-education, and an active role in personal wellness, celebrating peptides as unsung heroes at the heart of age-less living.

This podcast episode of "The Science of Age-less Living," hosted by Dr. Ethan , delves into the burgeoning world of peptide therapies and their role in modern medicine, particularly in the context of longevity and wellness. The discussion highlights the science behind peptides—short chains of amino acids with targeted effects on bodily processes—and contrasts their rapid rise in the wellness community with the traditional, cautious approach of Big Pharma. Through real-world case studies, market data, and expert insights, the episode explores whether peptides are a disruptive force or a complementary innovation, examining regulatory challenges, safety concerns, and rampant misinformation in the marketplace. Ultimately, the narrative underscores that while peptides hold immense promise for age-less living and transformative healthcare, their integration requires rigorous science, informed consumer choices, and collaboration between innovators and established pharmaceutical companies to maximize benefits and minimize risks.

Are NAD+ supplements the key to age-less living, or could they pose a cancer risk? In this episode of "The Science of Age-less Living," Dr. Ethan Hausman-Marquis delves into the complexities surrounding nicotinamide adenine dinucleotide (NAD+).

Discover its crucial role in energy production, DNA repair, and cellular health, as well as the rising popularity of NAD+ supplements.

We’ll examine the scientific evidence linking NAD+ to cancer growth and discuss the implications for those with a history of cancer. With caution advised for certain individuals, learn how to navigate the fascinating landscape of NAD+ supplementation.

Join us as we separate fact from fiction and empower your health journey!

#NADplus #AgingScience #HealthAndWellness #CancerResearch #AgeLessLiving

OUTLINE:

00:00:00 The Foundation of Age-less Science or Cancer Curse?

00:02:33 NAD+ Basics and Its Importance

00:06:16 Hype vs. Science

00:09:51 NAD+ and DNA Repair

00:11:23 NAD+ and the Immune System

00:13:01. Cancer Cells Hijacking NAD+

00:15:54. Concerns About NAD+ Supplementation and Cancer

00:17:16. NAD+'s Dual Role in Cancer Biology

00:18:44. Expert and Regulatory Perspectives on NAD+

00:22:22. Recommendations and Conclusion

Discover the groundbreaking potential of Retatrutide in our latest episode of "The Science of Age-less Living"! Join Dr. Ethan Hausman-Marquis as we explore this innovative triple-hormone medication that's changing the game in weight loss and metabolic health. With average weight reductions of 24.2% in just 48 weeks, Retatrutide is outpacing popular treatments like Ozempic and Mounjaro. We'll dive into its unique mechanism, the impressive clinical trial results, and why it's capturing the attention of bodybuilders and fitness enthusiasts alike. Don't miss this comprehensive overview of Retatrutide's benefits, risks, and future in obesity treatment!

#Retatrutide #WeightLoss #MetabolicHealth #HealthWellness #Bodybuilding #ObesityTreatment #DrEthanHausmanMarquis

OUTLINE:

00:00:00 Welcome to The Science of Age-less Living

00:02:32 What is Retatrutide?

00:03:37 How Retatrutide Works

00:04:38 Retatrutide's Uniqueness and Closing Thoughts

00:06:07 Clinical Trial Results and Benefits

00:06:33 Weight Loss Results

00:07:52 Metabolic and Health Benefits

00:09:50 Side Effects

00:11:11 Why Retatrutide Stands Out and Looking Ahead

00:13:01 Retatrutide vs. Mounjaro vs. Ozempic

00:13:39 Weight Loss Efficacy

00:14:58 Mechanism of Action

00:16:32 Cardiometabolic Benefits

00:18:01 Side Effects and Risks

00:19:32 Availability and Final Thoughts

00:21:23 Retatrutide and Bodybuilding

00:22:03 Fat Loss and Muscle Preservation

00:23:40 Glucagon Activation and Appetite Suppression

00:25:51 Potential Risks for Bodybuilders

00:27:28 Practical Considerations and Final Thoughts

00:30:06 The Future of Retatrutide

00:30:42 Why Retatrutide is a Game-Changer

00:32:31 Challenges and Considerations

00:34:19 What’s Next for Retatrutide?

00:35:57 Speculating on the Future

00:37:45 Conclusion