Dr. Chika Nwachukwu, a radiation oncologist at UCSD Moores Cancer Center, shared her journey from aspiring doctor in middle school to her current role. She detailed her educational path, including a PhD in breast cancer research and medical school at Mayo Clinic. Dr. Nwachukwu discussed her work in developing training curricula for hospitals in Kenya and Tanzania, emphasizing the importance of educational initiatives in low-resource settings. She highlighted the challenges of bringing advanced cancer treatments to these regions and her current research on vaccine uptake and brachytherapy in low-middle income countries. Dr. Nwachukwu also touched on the future of radiation oncology, including potential advancements in AI and automation.

Introduction to the Podcast

• Introduction to the podcast, emphasizing curiosity and the pursuit of knowledge in various scientific fields.
• The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science in partnership with UCSD Moores Cancer Research Center.
• Funding for the program is provided by Cloudcast Media.

Introduction of Co-Hosts and Guest

• Lena Adnan and Nebby Daniel, both post-bac scholars at UCSD Moores Cancer Center.
• Introduction of the guest, Dr. Chika Nwachukwu, a radiation oncologist.
• Dr. Nwachukwu shares her journey, starting with her early interest in medicine and her undergraduate studies at Grinnell College.

Dr. Nwachukwu's Journey to Radiation Oncology

• Dr. Nwachukwu describes her initial interest in medicine, influenced by a TV show, and her focus on sciences during college.
• She shares her experience at a summer research program at the University of Chicago, which shifted her focus from med school to a PhD in breast cancer research.
• Dr. Nwachukwu explains her decision to pursue a PhD after college, influenced by her research experience and the impact of her work on patients.
• She details her return to med school, her interest in oncology, and her eventual specialization in radiation oncology.

Personal Motivations and Rewards

• Dr. Nwachukwu discusses her motivations, including her family and her active lifestyle.
• She highlights the rewarding aspects of her job, such as helping patients and being part of their lives during vulnerable times.
• Dr. Nwachukwu shares her favorite inspirational quote and her interest in event planning as an alternative career.
• The co-hosts ask Dr. Nwachukwu about her favorite comfort food and her thoughts on the importance of family.

Developing Training Curricula for Low-Resource Countries

• Dr. Nwachukwu explains her work in developing training curricula for hospitals in Kenya and Tanzania.
• She shares her background, including her Nigerian heritage and her experiences with healthcare in Nigeria.
• Dr. Nwachukwu describes her involvement in medical missions and her decision to focus on educational contributions.
• She discusses the collaborations that led to her work in Kenya and Tanzania and the importance of networking in her career.

Challenges in Bringing Advanced Cancer Treatments to Low-Resource Settings

• Dr. Nwachukwu addresses the challenges of translating advanced cancer treatments to low-resource settings.
• She explains the differences in healthcare resources and the focus on infectious diseases in these regions.
• Dr. Nwachukwu emphasizes the importance of tailoring treatment approaches to the available resources.
• She discusses the role of the National Comprehensive Cancer Network (NCCN) guidelines in low-resource settings.

A Typical Day as a Radiation Oncologist

• Dr. Nwachukwu describes her typical day at UCSD Moores Cancer Center, focusing on breast and GYN patients.
• She explains her role as a brachytherapist and her responsibilities in treating patients and performing procedures.
• Dr. Nwachukwu highlights the busy and fulfilling nature of her clinical days.
• She shares her enjoyment of working with her hands and the satisfaction of treating patients.

Research Focus and Publications

• Dr. Nwachukwu discusses her current research focus on international work and publishing in low-middle income countries.
• She mentions her recent work on vaccine uptake in low-middle income countries and setting up brachytherapy practices in Nigeria.
• Dr. Nwachukwu is currently working on a manuscript documenting a similar effort in Tanzania.
• The co-hosts ask Dr. Nwachukwu about her thoughts on the importance of her PhD in her career.

Future of Radiation Oncology

• Dr. Nwachukwu shares her vision for the future of radiation oncology, emphasizing the advancements in treatment techniques.
• She discusses the potential role of robot-assisted therapy and automated treatment planning in the field.
• Dr. Nwachukwu expresses excitement about new technologies and therapies in cancer research.
• She highlights the potential for eradicating certain cancers, such as cervical cancer, through vaccines and other interventions.

Advice for Aspiring Scientists and Healthcare Professionals

• Dr. Nwachukwu encourages young listeners interested in cancer or radiation oncology to pursue the field.
• She emphasizes the rewarding nature of the work and the impact on patients' lives.
• Dr. Nwachukwu highlights the intersection of technology and clinical work in radiation oncology.
• She offers to connect with interested individuals and share more about her work and experiences.

"The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Max Arola, Sasha Goldschmied. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. 

About Cloudcast Media

As the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST platform to help amplify, augment, and accelerate the mission and reach of community social impact organizations.  For more information on Cloudcast Media, please visit their website at CloudCast Media. 
 
About UCSD Moores Cancer Center

Established in 1978, Moores Cancer Center at UC San Diego Health is one of just 57 National Cancer Institute-Designated Comprehensive Cancer Centers in the United States, and the only one in the San Diego region. Such centers are prominent among the leading institutions in the nation dedicated to scientific innovation and clinical excellence. From research in molecular genetics to the most advanced treatments, Moores Cancer Center is at the forefront of the fight against cancer, developing promising new therapies and making them available to cancer patients throughout the region. Our cancer services were ranked #1 in San Diego, with 10 specialties ranking nationally by U.S. News & World Report in its 2023-2024 "Best Hospitals" survey. For more information, please visit https://moorescancercenter.ucsd.edu/.


About Jackie Robinson Family YMCA

The Jackie Robinson Family YMCA serves over 20,000 youth and families each year through a wide variety of educational, recreational and sports programs. In one of San Diego's most critical communities, we have a daily opportunity to make a significant impact on thousands of lives. YMCA programs teach kids character values and valuable skills that will help them grow into responsible, successful adults. For more information, please visit https://www.ymcasd.org/locations/jackie-robinson-family-ymca.


About the Elementary Institute of Science

The Elementary Institute of Science (EIS) is a nonprofit organization committed to increasing lifelong opportunities for students of southeast San Diego through science, technology, engineering and math (STEM) education. Our after-school, weekend and school partnership programs broaden access to quality STEM experiences, foster critical thinking, expand technical skills and encourage students to pursue STEM careers. For more information, please visit https://eisca.org/.

The episode was recorded by the students and engineered / mixed / mastered by Christelle Auzas.

Dr. Silvia Vicenzi, a postdoctoral fellow at UC San Diego, discussed her journey from Italy to the U.S., highlighting her diverse educational background in biotechnology, molecular medicine, and neuroscience. She shared her research on bone marrow aging and its implications for cancer, using unique mouse models. Dr. Vicenzi emphasized the importance of biomarkers in early disease detection and personalized treatment. She also discussed her passion for mentoring students and her efforts to create a supportive community for postdoctoral researchers. Dr. Vicenzi's work aims to bridge basic biology with clinical applications, focusing on healthy aging and disease prevention.

Introduction to the Science Of Podcast Series

• Introduction to the podcast, emphasizing curiosity and the exploration of various scientific topics.
• The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science in partnership with UCSD Moores Cancer Center and UCSD campus.
• Funding for the program is provided by Cloudcast Media.
• Insight to the episode's focus on molecular mechanisms related to brain, cancer, and aging.

Meet the Co-Hosts and Guest

• Danielle-Elizabeth Mensah-Baah and her co-host, Dalia, a community health liaison at UCSD Moores Cancer Center.
• Michaela, a senior at Lincoln High School, introduces herself.
• The co-hosts express excitement about the episode and the guest, Dr. Silvia Vicenzi.

Dr. Silvia Vicenzi's Background

• Dr. Vicenzi shares her background, starting from her childhood in Italy, her curiosity, and her early interest in math, biology, and physics.
• She describes her educational journey, including her undergraduate degree in biotechnology, her internship in the UK, and her master's degree in Sweden.
• Dr. Vicenzi discusses her PhD in Australia, focusing on brain wiring and axon guidance, and her postdoctoral training at UC San Diego.

Impact of Studying in Different Countries

• Dr. Vicenzi explains that her global perspective and ability to adapt to different methods have enriched her approach to science.
• She emphasizes the importance of traveling and gaining diverse experiences to broaden one's knowledge and skills.
• Dr. Vicenzi shares how her experiences have helped her develop a unique approach to solving scientific challenges.

Fun Questions and Personal Insights

• Dr. Vicenzi shares that she would have coffee with Rita Levi Montalcini, a Nobel Prize winner from Italy, and discusses her admiration for Montalcini's resilience and contributions to science.
• She reveals her favorite midnight snack is pizza and her dream destination is the Galapagos Islands.
• Dr. Vicenzi shares that her biggest inspiration is her grandfather, who was a strong advocate for justice and values.

Dr. Vicenzi's Current Research and Mentoring Role

• Dr. Vicenzi describes her role as a postdoctoral fellow, leading projects on blood cancers and hematologic malignancies.
• She emphasizes her passion for mentoring students, helping them achieve their goals, and providing support through challenges.
• Dr. Vicenzi discusses her research on bone marrow aging and its implications for cancer treatment and healthy aging.

Biomarkers and Early Diagnosis

• Dr. Vicenzi explains that her lab is focused on discovering biomarkers for hematological disorders, such as multiple myeloma.
• She discusses the importance of detecting changes early to address them before the disease progresses.
• Dr. Vicenzi highlights the potential for personalized treatment approaches based on biomarkers.

Axon Guidance and Neurodevelopmental Disorders

• Dr. Vicenzi explains the process of axon guidance, where neurons sample their environment for cues to determine their connections.
• She discusses her PhD research on serotonin's role in axon guidance and its implications for neurodevelopmental disorders like autism and ADHD.
• Dr. Vicenzi shares her fascination with the complex process of neuronal circuit formation and its impact on behavior.

Dr. Vicenzi's Awards and Contributions

• Dr. Vicenzi mentions her postdoctoral fellowships, including one from the California Institute for Regenerative Medicine.
• She shares her pride in receiving the Japa award for advancing postdoctoral training at UC San Diego.
• Dr. Vicenzi discusses her involvement in creating a podcast to provide a platform for trainees to share their stories and experiences.

Audience Questions and Advice for Students

• Dr. Vicenzi advises students to follow their dreams, be determined, and find a supportive network.
• She emphasizes the importance of gratitude and learning from both good and challenging experiences.
• Dr. Vicenzi shares her belief that she wouldn't change anything in her journey, as it has shaped her into who she is today.

Future of Brain Research and Final Thoughts

• Dr. Vicenzi hopes that brain research will focus on empathy, community, and the strength that comes from belonging.
• She expresses her desire to continue making a positive impact on the scientific community and society.
•  Dr. Vicenzi encourages young listeners to be authentic and show up as their best selves in the world.

"The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Max Arola, Sasha Goldschmied. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. 

About Cloudcast Media

As the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST platform to help amplify, augment, and accelerate the mission and reach of community social impact organizations.  For more information on Cloudcast Media, please visit their website at CloudCast Media.  

About UCSD Moores Cancer Center

Established in 1978, Moores Cancer Center at UC San Diego Health is one of just 57 National Cancer Institute-Designated Comprehensive Cancer Centers in the United States, and the only one in the San Diego region. Such centers are prominent among the leading institutions in the nation dedicated to scientific innovation and clinical excellence. From research in molecular genetics to the most advanced treatments, Moores Cancer Center is at the forefront of the fight against cancer, developing promising new therapies and making them available to cancer patients throughout the region. Our cancer services were ranked #1 in San Diego, with 10 specialties ranking nationally by U.S. News & World Report in its 2023-2024 "Best Hospitals" survey. For more information, please visit https://moorescancercenter.ucsd.edu/.

About Jackie Robinson Family YMCA

The Jackie Robinson Family YMCA serves over 20,000 youth and families each year through a wide variety of educational, recreational and sports programs. In one of San Diego's most critical communities, we have a daily opportunity to make a significant impact on thousands of lives. YMCA programs teach kids character values and valuable skills that will help them grow into responsible, successful adults. For more information, please visit https://www.ymcasd.org/locations/jackie-robinson-family-ymca.

About the Elementary Institute of Science

The Elementary Institute of Science (EIS) is a nonprofit organization committed to increasing lifelong opportunities for students of southeast San Diego through science, technology, engineering and math (STEM) education. Our after-school, weekend and school partnership programs broaden access to quality STEM experiences, foster critical thinking, expand technical skills and encourage students to pursue STEM careers. For more information, please visit https://eisca.org/.

The episode was recorded by the students and engineered / mixed / mastered by Christelle Auzas.

The "Science Of Podcast" episode, hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science, features Dr. Blanca Equihua from UCSD's Morris Cancer Center. Dr. Equihua discusses her background in medicine and transition to research, focusing on reproductive health and onco-fertility. She highlights the impact of cancer treatments on fertility, the importance of including Spanish-speaking patients in clinical trials, and the challenges faced by underserved communities. Dr. Equihua emphasizes the role of AI in healthcare and the need for universal access to fertility benefits. She encourages young scientists to stay focused and seek mentorship.

Introduction to the Science Of Podcast Series

• Introduction to the podcast, emphasizing curiosity and the exploration of various scientific topics.
• The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.
• Partnerships include the UCSD Morris Cancer Research Center and Cloudcast Media.
• The podcast aims to cover diverse scientific topics, starting with Obstetrics and Gynecology in this episode.

Introduction of Co-Hosts and Guest

• Kelsey Lewis, introduces herself and the episode's focus on Obstetrics and Gynecology.
• Co-hosts Max, Danielle-Elizabeth, Noor, and Sasha introduce themselves.
• Max, introduces Dr. Blanca Equihua, who prefers to be called Dr. Blanca.
• Dr. Blanca shares her background in medicine, her move to San Diego, and her transition to research.

Dr. Blanca's Journey and Research Background

• Dr. Blanca discusses her medical background in Mexico and her residency training in adult medicine.
• She explains her transition to research, motivated by her experiences in clinical settings.
• Dr. Blanca moved to San Diego in 2010 to join Dr. Irene Su's lab at UCSD.
• She highlights the importance of including Spanish-speaking patients in clinical trials.

Research Differences Between Mexico and the United States

• Dr. Blanca compares her research experiences in Mexico and the United States.
• She shares her early research experience in Tijuana, focusing on HIV and condom use among sex workers.
• Dr. Blanca discusses the funding mechanisms for clinical research in Mexico, including Conacyt.
• She emphasizes the importance of public health research in addressing issues in underserved communities.

Dr. Blanca's Hobbies and Personal Interests

• Dr. Blanca shares her hobbies, including volunteering, world cuisines, reading, and plant care.
• She expresses her passion for plants, owning over 58 plants and participating in garden exchanges.
• Dr. Blanca reveals her childhood dream of becoming a marine biologist, inspired by nature documentaries.
• She shares her favorite hobbies and personal inspirations, including her daughter.

Introduction to Onco Fertility

• Dr. Blanca explains the concept of oncofertility, focusing on how cancer impacts fertility.
• She discusses the importance of fertility preservation for cancer patients.
• Dr. Blanca highlights the challenges patients face in accessing fertility care due to insurance barriers.
• She emphasizes the need for better access to fertility care for cancer patients.

Dr. Blanca's Role in Reproductive Health

• Dr. Blanca shares her motivation for joining Dr. Irene Su's lab, focusing on Spanish-speaking patients.
• She discusses the importance of translating research documents into Spanish for better patient understanding.
• Dr. Blanca highlights the impact of cancer treatments on reproductive health and the need for fertility preservation.
• She emphasizes the importance of providing accurate information to patients about their fertility risks.

Impact of Cancer Treatments on Fertility

• Dr. Blanca explains how chemotherapy and radiation affect reproductive health.
• She discusses the importance of referrals for fertility specialists to preserve fertility.
• Dr. Blanca highlights the need for novel therapies to improve fertility post-cancer.
• She emphasizes the importance of understanding the impact of novel therapies on reproductive health.

Audience Questions and Answers

• Audience member Sarah asks about trends in underserved communities and their impact on treatment plans.
• Dr. Blanca shares her experiences working with older adults in San Quintin, Baja California.
• She discusses the challenges faced by older adults, including lack of access to primary care and transportation.
• Dr. Blanca emphasizes the need for culturally tailored public health strategies for underserved communities.

Future of Medicine and Public Health

• Audience member Sarah asks about recommendations for improving public health approaches.
• Dr. Blanca emphasizes the importance of researchers being in the community and understanding their needs.
• She discusses the need for strategies to improve resilience in older adults.
• Dr. Blanca highlights the importance of preventing falls and other impairments to improve health outcomes.

Futuristic Questions and Closing Remarks

• Audience member Sarah asks about closing gaps in maternal health outcomes.
• Dr. Blanca emphasizes the need for universal access to healthcare and preventive medicine.
• She discusses the potential impact of AI on healthcare, including screening and treatment protocols.
• Dr. Blanca shares her vision of AI as an ally for doctors in the future.

Closing Remarks and Contact Information

• Dr. Blanca provides her contact information for those interested in learning more about her work.
• She encourages young listeners to stay focused, be curious, and seek mentors in their fields.
• The podcast team thanks Dr. Blanca and the audience for their participation.
• The episode concludes with a reminder to like, subscribe, and share the podcast.

"The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Max Arola, Sasha Goldschmied. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. 

About Cloudcast Media

As the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST platform to help amplify, augment, and accelerate the mission and reach of community social impact organizations.  For more information on Cloudcast Media, please visit their website at CloudCast Media.  

About UCSD Moores Cancer Center

Established in 1978, Moores Cancer Center at UC San Diego Health is one of just 57 National Cancer Institute-Designated Comprehensive Cancer Centers in the United States, and the only one in the San Diego region. Such centers are prominent among the leading institutions in the nation dedicated to scientific innovation and clinical excellence. From research in molecular genetics to the most advanced treatments, Moores Cancer Center is at the forefront of the fight against cancer, developing promising new therapies and making them available to cancer patients throughout the region. Our cancer services were ranked #1 in San Diego, with 10 specialties ranking nationally by U.S. News & World Report in its 2023-2024 "Best Hospitals" survey. For more information, please visit https://moorescancercenter.ucsd.edu/.

About Jackie Robinson Family YMCA

The Jackie Robinson Family YMCA serves over 20,000 youth and families each year through a wide variety of educational, recreational and sports programs. In one of San Diego's most critical communities, we have a daily opportunity to make a significant impact on thousands of lives. YMCA programs teach kids character values and valuable skills that will help them grow into responsible, successful adults. For more information, please visit https://www.ymcasd.org/locations/jackie-robinson-family-ymca.

About the Elementary Institute of Science

The Elementary Institute of Science (EIS) is a nonprofit organization committed to increasing lifelong opportunities for students of southeast San Diego through science, technology, engineering and math (STEM) education. Our after-school, weekend and school partnership programs broaden access to quality STEM experiences, foster critical thinking, expand technical skills and encourage students to pursue STEM careers. For more information, please visit https://eisca.org/.

The episode was recorded by the students and engineered / mixed / mastered by Christelle Auzas.

"The Science Of" podcast episode features Dr. Miguel Reina Campos discussing his journey from Spain to the U.S., focusing on T cells and cancer. Dr. Campos explains the role of tissue-resident memory T cells in fighting diseases, emphasizing their importance in solid tumors. He highlights the impact of hormones like testosterone on immune cell function and the potential of spatial transcriptomics in cancer diagnosis and treatment. Dr. Campos also discusses the challenges of studying immune cells in tissues and the future of cancer treatment, including personalized immunotherapies and mRNA vaccination. He advises aspiring scientists to stay resilient. 

Introduction to the Science of Podcast Series

• The students introduce the podcast, emphasizing curiosity and the exploration of various scientific topics.
• The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.
• Partnerships include the UCSD Moores Cancer Center and Cloudcast Media
• The program is provided by SchoolCAST, a podcast and curriculum program from Cloudcast Media.
• The students welcome listeners and introduce the episode's focus on T cells and cancer.
• Co-hosts Sasha, Max, and the gues, Dr. Miguel Reina Campos, are introduced.

Dr. Miguel Reina Campos' Background and Journey

• Dr. Reina Campos shares his background, starting from his birth in Barcelona, Spain, and his education in molecular biology and biochemistry.
• He discusses his decision to study in Germany during the 2008 economic crisis and his subsequent move to the U.S. for a master's degree at Scripps Research Institute.
• His interest in cancer biology and the biology of cancer cells is highlighted.
• Dr. Reina Campos explains the complexity of tumors and the role of non-tumor cells in tumor growth.
• He discusses the importance of the immune system in fighting cancer and the impact of immunotherapy.

Rapid Fire Questions and Personal Interests

• Dr. Reina Campos answers rapid-fire questions about his career and personal interests.
• He shares his initial career interests, including a desire to be a lifeguard and a professional basketball player.
• His favorite surf spot in San Diego is revealed to be Horseshoe.
• Dr. Reina Campos discusses the most fascinating discoveries of his career, including the plasticity of tumor cells and the diversity of immune cells in different tissues.
• He mentions his hobby of paragliding and describes a typical day in his lab, which is chaotic and filled with various tasks.

Tissue Resident Memory T Cells and Their Role in Disease

• Dr. Reina Campos explains the concept of tissue resident memory T cells and their importance in fighting diseases.
• He describes how these T cells live in tissues and protect against infections and tumors.
• The challenges of enhancing anti-tumor responses driven by T cells are discussed.
• The role of memory in the immune system and its impact on disease protection is explained.
• The influence of hormones like testosterone on the immune system, especially in the context of cancer, is explored.

Gender Differences in Immune Responses and Cancer Susceptibility

• Dr. Reina Campos discusses the differences in T cell function between genders and its impact on disease susceptibility.
• He explains the role of the thymus in T cell education and how testosterone affects it.
• The challenges of studying immune cells within tissues and the use of spatial transcriptomics are highlighted.
• The potential for using spatial transcriptomics to develop new treatments for patients is discussed.
• The importance of early diagnosis and prevention in cancer treatment is emphasized.

Future Directions in Cancer Treatment and Emerging Risks

• Dr. Reina Campos speculates on the future of cancer treatment and the potential for eradicating certain cancers.
• He discusses the role of diagnostics in preventing disease and the impact of diet on immune cell function.
• The potential impact of microplastics on immune responses and disease is mentioned.
• The use of personalized immunotherapies and the potential of mRNA vaccination in cancer treatment are explored.
• The high cost and limited accessibility of cellular therapies are noted.

Advice for Aspiring Scientists and Contact Information

• Dr. Reina Campos advises aspiring scientists to stay resilient and persevere in their careers.
• He provides contact information for those interested in learning more about his work.
• The episode concludes with the hosts thanking the audience and promoting future episodes of the Science of Podcast series.

"The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Max Arola, Sasha Goldschmied. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. 

About Cloudcast Media

As the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST platform to help amplify, augment, and accelerate the mission and reach of community social impact organizations.  For more information on Cloudcast Media, please visit their website at CloudCast Media.  

About UCSD Moores Cancer Center

Established in 1978, Moores Cancer Center at UC San Diego Health is one of just 57 National Cancer Institute-Designated Comprehensive Cancer Centers in the United States, and the only one in the San Diego region. Such centers are prominent among the leading institutions in the nation dedicated to scientific innovation and clinical excellence. From research in molecular genetics to the most advanced treatments, Moores Cancer Center is at the forefront of the fight against cancer, developing promising new therapies and making them available to cancer patients throughout the region. Our cancer services were ranked #1 in San Diego, with 10 specialties ranking nationally by U.S. News & World Report in its 2023-2024 "Best Hospitals" survey. For more information, please visit https://moorescancercenter.ucsd.edu/.

About Jackie Robinson Family YMCA

The Jackie Robinson Family YMCA serves over 20,000 youth and families each year through a wide variety of educational, recreational and sports programs. In one of San Diego's most critical communities, we have a daily opportunity to make a significant impact on thousands of lives. YMCA programs teach kids character values and valuable skills that will help them grow into responsible, successful adults. For more information, please visit https://www.ymcasd.org/locations/jackie-robinson-family-ymca.

About the Elementary Institute of Science

The Elementary Institute of Science (EIS) is a nonprofit organization committed to increasing lifelong opportunities for students of southeast San Diego through science, technology, engineering and math (STEM) education. Our after-school, weekend and school partnership programs broaden access to quality STEM experiences, foster critical thinking, expand technical skills and encourage students to pursue STEM careers. For more information, please visit https://eisca.org/.

The episode was recorded by the students and engineered / mixed / mastered by Christelle Auzas.

"The Science Of" podcast episode explores biotechnology and immune cell communication with Dr. Anshuman Bhanja from UCSD. Dr. Bhanja discusses his journey from India to the U.S., his switch from engineering to biology, and his research on B cells and T cells. He explains how immune cells communicate using the actin cytoskeleton and the role of
N-WASP. Dr. Bhanja also touches on the challenges of cancer immunotherapy, the potential of AI in molecular biology, and his vision for creating chimeric antigen receptor B cells to combat cancer metastasis. The episode emphasizes curiosity, innovation, and the importance of boldness in scientific research.

Introduction to "The Science Of" Podcast Series

• Introduction of the podcast, emphasizing curiosity and the exploration of various scientific topics.
• The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.
• Partnerships include the UCSD Moores Cancer Center and Cloudcast Media
• The program is provided by SchoolCAST, a podcast and curriculum program from Cloudcast Media.

Welcome to The Science Of" Cellular Communication Episode

• Listeners are welcomed to "The Science Of" Podcast series, focusing on biotechnology and immune cell communication.
• The episode is hosted by Max, Sasha, and Zahraa, with a special guest, Dr. Anshuman Bhanja.
• Sasha, Max, and Zahraa introduce themselves as high school students.
• The episode aims to explore the molecular choreography inside our bodies and the potential for life-saving research.

Introduction of Dr. Anshuman Bhanja

• Dr. Bhanja shares his background, starting in India, moving to the US in 2016, and pursuing a PhD in cell biology and molecular genetics.
• He discusses his switch from engineering to biology due to a middle school biology teacher and his interest in cars.
• Dr. Bhanja explains the challenges of research in India compared to the US, including funding and reagent availability.

Dr. Bhanja's Journey and Research Focus

• Dr. Bhanja shares his journey from hating biology in middle school to falling in love with it in high school.
• He discusses the differences in research support between India and the US.
• Dr. Bhanja talks about his favorite midnight snack, Oreos, and his dream of visiting Hawaii.
• He mentions his biggest inspiration, Dr. Shinya Yamanaka, and his favorite hobby, surfing.

Exploring Cellular Communication

• Dr. Bhanja explains cellular communication, emphasizing how cells talk to each other to form tissues and organs.
• He shares his fascination with immunology, particularly how cells work together to protect the body.
• Dr. Bhanja discusses the role of B cells in producing antibodies and their communication with T cells.
• He explains the actin cytoskeleton's role in cellular communication and its impact on immune cell function.

Understanding Cancer and Immune Cell Communication

• Dr. Bhanja discusses how cancer cells evade the immune system by hijacking communication pathways.
• He explains the selection process that makes tumors stronger and more resistant to treatment.
• Dr. Bhanja talks about the role of N-WASP in immune cell function and its critical focus in his research.
• He shares his interest in studying B cells due to their role in immune function and his mentor's expertise in immunology.

Impact of Research on Patients

• Dr. Bhanja discusses the translational research on car-T cells and their potential impact on cancer treatment.
• He explains the challenges of translating developmental research into clinical applications.
• Dr. Bhanja shares his thoughts on the future of AI in molecular biology research and its potential to predict protein structures.
• He elaborates on the process of creating protein crystals for structural analysis.

Future of Immune Cell Communication Research

• Dr. Bhanja discusses the potential of understanding immune cell communication to unlock new therapies and technologies.
• He shares his vision of creating chimeric antigen receptor B cells to target cancer cells more effectively.
• Dr. Bhanja emphasizes the importance of curiosity and boldness in scientific research.
• He provides his email for listeners interested in learning more about his work.

Conclusion and Final Thoughts

• Dr. Bhanja shares his message to young listeners, encouraging them to be bold and brave in pursuing their scientific interests.
• He provides his email for further inquiries about his research.
• The episode concludes with thanks from the hosts and a reminder of the podcast's collaboration with various institutions.
• The podcast aims to satisfy scientific curiosities and explore fascinating topics in the world of science.

"The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Zahraa Munaim, Max Arola, Sasha Goldschmied.

The episode was engineered /mixed/mastered by Christelle Auzas from Cloudcast Media. 

About Cloudcast Media

As the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST platform to help amplify, augment, and accelerate the mission and reach of community social impact organizations.  For more information on Cloudcast Media, please visit their website at CloudCast Media.  

About UCSD Moores Cancer Center

Established in 1978, Moores Cancer Center at UC San Diego Health is one of just 57 National Cancer Institute-Designated Comprehensive Cancer Centers in the United States, and the only one in the San Diego region. Such centers are prominent among the leading institutions in the nation dedicated to scientific innovation and clinical excellence. From research in molecular genetics to the most advanced treatments, Moores Cancer Center is at the forefront of the fight against cancer, developing promising new therapies and making them available to cancer patients throughout the region. Our cancer services were ranked #1 in San Diego, with 10 specialties ranking nationally by U.S. News & World Report in its 2023-2024 "Best Hospitals" survey. For more information, please visit https://moorescancercenter.ucsd.edu/.

About Jackie Robinson Family YMCA

The Jackie Robinson Family YMCA serves over 20,000 youth and families each year through a wide variety of educational, recreational and sports programs. In one of San Diego's most critical communities, we have a daily opportunity to make a significant impact on thousands of lives. YMCA programs teach kids character values and valuable skills that will help them grow into responsible, successful adults. For more information, please visit https://www.ymcasd.org/locations/jackie-robinson-family-ymca.

About the Elementary Institute of Science

The Elementary Institute of Science (EIS) is a nonprofit organization committed to increasing lifelong opportunities for students of southeast San Diego through science, technology, engineering and math (STEM) education. Our after-school, weekend and school partnership programs broaden access to quality STEM experiences, foster critical thinking, expand technical skills and encourage students to pursue STEM careers. For more information, please visit https://eisca.org/.

The "Science of" podcast episode, hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science, features Dr. Alexander Wallace, a postdoctoral fellow at UCSD's psychiatry department. Dr. Wallace discusses the impact of substance use on neurodevelopment and aerobic fitness in young adults. He highlights the complexities of substance use, including the misconceptions about users and the effects of substances like cannabis, alcohol, and nicotine on the developing brain. Dr. Wallace also touches on the role of aerobic fitness in brain health and the ABCD study, which aims to understand the factors influencing substance use. The episode concludes with Dr. Wallace sharing his journey and advice for aspiring scientists.OutlineIntroduction to the Science of Podcast Series

• Speaker 1 introduces the podcast, emphasizing curiosity and the pursuit of knowledge in various scientific topics.
• The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science, in partnership with UCSD Moores Cancer Research Center.
• Funding for the program is provided by Schoolcast, a cloudcast media program.
• Speaker 2 welcomes listeners to the series, highlighting the episode's focus on the effects of certain drugs on neurodevelopment and aerobic fitness.

Introduction of Co-Hosts and Guest

• Speaker 2 introduces Sasha, the co-host, and mentions the special guest, Dr. Alexander Wallace.
• Speaker 3 and Speaker 4 introduce themselves as junior students at High Tech High and East Village, respectively.
• Dr. Wallace is introduced as a postdoctoral fellow in the psychiatry department at UCSD, with a background in clinical psychology and substance use research.

Dr. Wallace's Journey and Research Interests

• Dr. Wallace shares his journey from obtaining a PhD in Clinical Psychology at the University of Wisconsin, Milwaukee, to his current position at UCSD.
• He mentions his mentor, a world-class leader in adolescent substance use and neurodevelopment.
• Dr. Wallace discusses his interest in STEM, influenced by his parents who were teachers, and his chance encounter with research during his undergraduate studies.
• He explains his focus on ADHD and substance use, which led to his current research at UCSD.

Rapid Fire Questions and Personal Insights

• Dr. Wallace answers rapid-fire questions about his first science experiment, favorite scientist, music for concentration, travel destination, favorite place to eat in San Diego, and biggest inspiration.
• He shares that his biggest inspiration is his mentor because of her kindness and support.
• Dr. Wallace discusses the importance of education and open communication about substance use to reduce stigma and misconceptions.

Myths About Substance Use and Brain Development

• Dr. Wallace addresses common myths about cannabis, alcohol, and nicotine, emphasizing that substance use does not make someone inherently bad.
• He explains the complex nature of substance use and the various factors influencing it, such as biology, peers, and family history.
• Dr. Wallace highlights the importance of educating young adults about the risks and impacts of substance use on the developing brain.

Impact of Substances on Brain Development

• Dr. Wallace explains how substances like alcohol, cannabis, and nicotine affect the developing brain, particularly the frontal regions responsible for executive functions.
• He discusses the neuroplasticity of the adolescent brain and how substance use can lead to underdevelopment of these regions.
• Dr. Wallace emphasizes the need for more research to understand the specific effects of different substances on the brain.

Neural Processes of Addiction and Gender Differences

• Dr. Wallace explains the neural processes of addiction, focusing on the role of dopamine and the cycle of substance use.
• He discusses the differences in how alcohol affects young women versus young men, noting that women may be more vulnerable to the effects of alcohol.
• Dr. Wallace highlights the need for more research on substance use in women to better understand and address these differences.

Role of Aerobic Fitness in Brain Health

• Dr. Wallace discusses the role of aerobic fitness in brain health and mental function, particularly as an intervention for substance use.
• He explains how exercise can help upregulate dopamine receptors and mitigate the harm from substance use.
• Dr. Wallace mentions his work on the Adolescent Brain Cognitive Development (ABCD) study, which aims to understand the factors influencing substance use and brain development.

Newest Discoveries and COVID-19 Impact

• Dr. Wallace shares his most recent discovery, a study on the impact of cannabis use on depression and brain volume in adolescents.
• He discusses the findings of the ABCD study, which showed that adolescent substance use decreased during the COVID-19 pandemic.
• Dr. Wallace highlights the importance of understanding the factors influencing substance use and the need for continued research.

Future Directions and Final Thoughts

• Dr. Wallace expresses his hope for future research to prevent or delay substance use in adolescence.
• He shares his advice for young listeners interested in science and healthcare, encouraging them to get engaged and take opportunities to learn and grow.
• Dr. Wallace provides information on how listeners can reach out to him or learn more about his work through the ABCD study and UCSD.

"The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Zahraa Munaim, Max Arola, and Sasha Goldschmied. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. 

About Cloudcast Media

As the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST platform to help amplify, augment, and accelerate the mission and reach of community social impact organizations.  For more information on Cloudcast Media, please visit their website at CloudCast Media.  

About UCSD Moores Cancer Center

Established in 1978, Moores Cancer Center at UC San Diego Health is one of just 57 National Cancer Institute-Designated Comprehensive Cancer Centers in the United States, and the only one in the San Diego region. Such centers are prominent among the leading institutions in the nation dedicated to scientific innovation and clinical excellence. From research in molecular genetics to the most advanced treatments, Moores Cancer Center is at the forefront of the fight against cancer, developing promising new therapies and making them available to cancer patients throughout the region. Our cancer services were ranked #1 in San Diego, with 10 specialties ranking nationally by U.S. News & World Report in its 2023-2024 "Best Hospitals" survey. For more information, please visit https://moorescancercenter.ucsd.edu/.

About Jackie Robinson Family YMCA

The Jackie Robinson Family YMCA serves over 20,000 youth and families each year through a wide variety of educational, recreational and sports programs. In one of San Diego's most critical communities, we have a daily opportunity to make a significant impact on thousands of lives. YMCA programs teach kids character values and valuable skills that will help them grow into responsible, successful adults. For more information, please visit https://www.ymcasd.org/locations/jackie-robinson-family-ymca.

About the Elementary Institute of Science

The Elementary Institute of Science (EIS) is a nonprofit organization committed to increasing lifelong opportunities for students of southeast San Diego through science, technology, engineering and math (STEM) education. Our after-school, weekend and school partnership programs broaden access to quality STEM experiences, foster critical thinking, expand technical skills and encourage students to pursue STEM careers. For more information, please visit https://eisca.org/.

The episode was recorded by the students and engineered / mixed / mastered by Christelle Auzas.

"The Science Of" Podcast episode features Dr. Jacopo Annese, a neuroscientist who is the CEO and Founder of The Brain Observatory, discussing his work on human brain mapping and preservation. Dr. Annese explains his journey from studying zoology to neuroscience, emphasizing the importance of preserving brain tissue for scientific discovery. He describes the process of brain mapping, which involves slicing and digitizing brain samples, and highlights the variability in brain structures. Dr. Annese also discusses the potential of AI in analyzing brain data and the importance of building a global brain bank for personalized medicine. The episode concludes with Dr. Annese advising aspiring scientists to be resilient and independent.

Introduction to the Science of Podcast Series

• Speaker 1 introduces the podcast, emphasizing curiosity and the exploration of various scientific topics.
• The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.
• Partnerships include the UCSD Moores Cancer Center and the extended UCSD campus.
• Funding for the program is provided by SchoolCast, a cloudcast media program.

Introduction to the Episode and Guests

• Speaker 2 welcomes listeners to the Science of Podcast series, focusing on human brain mapping and brain tissue preservation.
• Kelsey Lewis introduces herself and the co-hosts: Danielle-Elizabeth, Josue, and Max.
• The co-hosts express excitement about learning new things in each episode.
• Kelsey introduces the guest, Dr. Annese, and asks him to introduce himself.

Dr. Jacopo's Background and Journey

• Dr. Annese shares his background, mentioning his friendship with Charles and their shared passion for education.
• He describes his journey from studying biology and zoology to mapping the human brain.
• Dr. Annese recounts his experience at a conference in Moscow where he saw a neuron for the first time, sparking his interest in neuroscience.
• He discusses his educational path, including his time at UC Davis and Dartmouth, and his transition to studying human brains.

Dr. Jacopo's Work in Documentary Projects

• Dr. Annese explains how he began to bring neuroscience to the screen due to media requests at UCSD.
• He shares his experience of telling his own story rather than letting others do it.
• Dr. Annese discusses the potential of scientists telling their own stories and the importance of communication in science.

Rapid Fire Questions with Dr. Annese

• Dr. Annese answers questions about his inspirations, the most valuable thing he learned, his favorite animal, and his favorite place to study.
• He shares his appreciation for San Diego and his dream of having his own lab.
• Dr. Annese discusses his favorite place to study, mentioning London and Dartmouth.
• He talks about his favorite place in San Diego and his appreciation for the space it offers.

Dr. Annese's Innovative Approach to Brain Mapping

• Dr. Annese explains his time-honored technique of brain mapping and preservation.
• He describes the process of slicing and preserving the brain
• Dr. Annese discusses the importance of preserving the morphology of the brain and the challenges of working with human brains.
• He shares his experience of developing a relationship with brain donors and the emotional aspect of his work.

Challenges and Breakthroughs in Brain Mapping

• Dr. Annese talks about the challenges of mapping the human brain due to its variability.
• He explains the importance of understanding the structural map of the brain and its connections.
• Dr. Annese discusses the potential of using AI to analyze brain data and make predictions.
• He shares his experience of building his own microscope and the importance of solving problems in research.

Future of Brain Mapping and Personalized Medicine

• Dr. Annese discusses the potential of using brain mapping to make predictions and improve clinical care.
• He explains the importance of having a large dataset of brains to understand disease progression.
• Dr. Annese shares his vision of creating a world brain bank and the challenges of running a nonprofit lab.
• He talks about the potential of using brain mapping to help patients and make accurate diagnoses.

Final Thoughts and Advice for Aspiring Scientists

• Dr. Annese advises aspiring scientists to be resilient, rebellious, and confident in their own path.
• He emphasizes the importance of mentorship but also the need to think independently.
• Dr. Annese encourages students to explore and dissect brains to gain a deeper understanding of neuroscience.
• He shares his contact information and invites listeners to visit the Brain Observatory and learn more about his work.

"The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Max Arola, Sasha Goldschmied, Josue Castillo, Evan Sosa, and Kelsey Lewis. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. 

About Cloudcast Media

As the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST platform to help amplify, augment, and accelerate the mission and reach of community social impact organizations.  For more information on Cloudcast Media, please visit their website at CloudCast Media.  

About UCSD Moores Cancer Center

Established in 1978, Moores Cancer Center at UC San Diego Health is one of just 57 National Cancer Institute-Designated Comprehensive Cancer Centers in the United States, and the only one in the San Diego region. Such centers are prominent among the leading institutions in the nation dedicated to scientific innovation and clinical excellence. From research in molecular genetics to the most advanced treatments, Moores Cancer Center is at the forefront of the fight against cancer, developing promising new therapies and making them available to cancer patients throughout the region. Our cancer services were ranked #1 in San Diego, with 10 specialties ranking nationally by U.S. News & World Report in its 2023-2024 "Best Hospitals" survey. For more information, please visit https://moorescancercenter.ucsd.edu/.

About Jackie Robinson Family YMCA


The Jackie Robinson Family YMCA serves over 20,000 youth and families each year through a wide variety of educational, recreational and sports programs. In one of San Diego's most critical communities, we have a daily opportunity to make a significant impact on thousands of lives. YMCA programs teach kids character values and valuable skills that will help them grow into responsible, successful adults. For more information, please visit https://www.ymcasd.org/locations/jackie-robinson-family-ymca.

About the Elementary Institute of Science

The Elementary Institute of Science (EIS) is a nonprofit organization committed to increasing lifelong opportunities for students of southeast San Diego through science, technology, engineering and math (STEM) education. Our after-school, weekend and school partnership programs broaden access to quality STEM experiences, foster critical thinking, expand technical skills and encourage students to pursue STEM careers. For more information, please visit https://eisca.org/.

The episode was recorded by the students and engineered / mixed / mastered by Christelle Auzas.

The Science of Podcast episode features Dr. Asona Lui, an assistant professor in radiation oncology at UCSD Moores Cancer Center, discussing breast cancer and immunology. Dr. Lui specializes in triple-negative breast cancer, which lacks hormone receptors and HER2, making it resistant to standard treatments. She develops mouse models to study the disease and its response to immunotherapy and radiation. Dr. Lui emphasizes the importance of understanding cancer-immune system interactions and the potential of AI and robotic surgery in future healthcare. She advises young scientists to embrace diverse interests and seize opportunities, even if they seem unrelated to their main field.

Outline Introduction to the Science of Podcast Series

• Speaker 1 introduces the podcast, emphasizing curiosity and the pursuit of knowledge in various scientific fields.
• The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science, in partnership with UCSD Moores Cancer Center.
• Funding for the program is provided by Cloudcast Media.
• Speaker 2 welcomes listeners to the series, highlighting the focus on different scientific topics in each episode.

Introduction to the Episode's Guests and Co-Hosts

• Speaker 2 introduces the episode's topic: radiation oncology, with a focus on breast cancer and immunology.
• Dr. Asona Lui is introduced as the guest, specializing in treating breast cancer and triple-negative breast cancer.
• Co-hosts Kelsey, Zahraa, Danielle-Elizabeth Mensah-Baah, Max, August, and Jose Castillo introduce themselves as students from various schools.

Dr. Asona Lui's Background and Journey

• Dr. Lui shares her background, including her BA in African Studies and her interest in understanding her cultural roots.
• She discusses her family's background and how it influenced her academic and career choices.
• Dr. Lui explains her transition from African Studies to cancer research, highlighting the importance of understanding cultural influences on health.
• She mentions her involvement in acting and performing arts, which she believes has contributed to her success in science.

Balancing Science and the Arts

• One of the co-hosts asks Dr. Lui about balancing her interest in the arts with her scientific career.
• Dr. Lui shares her experience of participating in the arts during medical school and how it helped her mental health.
• She emphasizes the importance of finding time for hobbies and incorporating them into daily life.
• Dr. Lui discusses her involvement in singing with the La Jolla Symphony and how it feeds her soul.

Dr. Lui's Research and Discoveries

• Dr. Lui explains the basics of cancer and immunology, emphasizing the role of the immune system in recognizing and fighting cancer.
• She describes her research on triple-negative breast cancer and the challenges of treating it without specific targeted therapies.
• Dr. Lui shares a significant discovery in her research: the role of interferon in cancer cells, which was unexpected and changed their understanding of cancer immunology.
• She discusses the development of mouse models for triple-negative breast cancer to better understand and treat the disease.

Challenges and Future Directions in Cancer Research

• Dr. Lui talks about the challenges of treating triple-negative breast cancer and the importance of developing better mouse models.
• She explains the role of immunotherapy and radiation in treating cancer and the need for more effective treatments.
• Dr. Lui shares her vision for the future of cancer research, including the use of MRI scans to monitor cancer treatment more effectively.
• She discusses the potential role of AI and robots in healthcare, particularly in matching patients to clinical trials and performing surgeries remotely.

Audience Questions and Dr. Lui's Advice

• The co-hosts ask Dr. Lui about her current research and how it could be applied to cancer treatment.
• Dr. Lui explains the process of creating mouse models for triple-negative breast cancer and the importance of having a fully functioning immune system in the mice.
• She shares her advice for young people interested in science and healthcare, emphasizing the importance of following their passions and taking opportunities.
• Dr. Lui provides her email address for listeners who want to reach out and discuss science and cancer research further.

Conclusion and Closing Remarks

• The co-hosts thank Dr. Lui for her time and insights, expressing their appreciation for the episode.
• Dr. Lui reiterates her commitment to helping patients and advancing cancer research.
• The episode concludes with a reminder of the podcast's mission to explore various scientific topics and inspire curiosity.
• The co-hosts sign off, encouraging listeners to stay tuned for future episodes of the Science of Podcast series.

"The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Max Arola, August Ou, Josue Castillo, Evan Sosa, and Kelsey Lewis. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. 

About Cloudcast Media

As the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST platform to help amplify, augment, and accelerate the mission and reach of community social impact organizations.  For more information on Cloudcast Media, please visit their website at CloudCast Media.  

About UCSD Moores Cancer Center

Established in 1978, Moores Cancer Center at UC San Diego Health is one of just 57 National Cancer Institute-Designated Comprehensive Cancer Centers in the United States, and the only one in the San Diego region. Such centers are prominent among the leading institutions in the nation dedicated to scientific innovation and clinical excellence. From research in molecular genetics to the most advanced treatments, Moores Cancer Center is at the forefront of the fight against cancer, developing promising new therapies and making them available to cancer patients throughout the region. Our cancer services were ranked #1 in San Diego, with 10 specialties ranking nationally by U.S. News & World Report in its 2023-2024 "Best Hospitals" survey. For more information, please visit https://moorescancercenter.ucsd.edu/.

About Jackie Robinson Family YMCA

The Jackie Robinson Family YMCA serves over 20,000 youth and families each year through a wide variety of educational, recreational and sports programs. In one of San Diego's most critical communities, we have a daily opportunity to make a significant impact on thousands of lives. YMCA programs teach kids character values and valuable skills that will help them grow into responsible, successful adults. For more information, please visit https://www.ymcasd.org/locations/jackie-robinson-family-ymca.

About the Elementary Institute of Science

The Elementary Institute of Science (EIS) is a nonprofit organization committed to increasing lifelong opportunities for students of southeast San Diego through science, technology, engineering and math (STEM) education. Our after-school, weekend and school partnership programs broaden access to quality STEM experiences, foster critical thinking, expand technical skills and encourage students to pursue STEM careers. For more information, please visit https://eisca.org/.

The episode was recorded by the students and engineered / mixed / mastered by Christelle Auzas.

Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.

The "Science of" podcast episode features Dr. Sofia Cardenas-Alcoser from UCSD's Moores Cancer Center discussing her journey from chemistry to biomedical research, focusing on cell signaling and cancer. She explains the complexities of G protein-coupled receptors (GPCRs) and their role in cancer. Dr. Cardenas-Alcoser highlights a significant discovery linking G protein alpha subunits to immune system infiltration in tumors, potentially leading to new cancer treatments. She emphasizes the importance of mentorship and resilience in research and shares her passion for video games and Twitch streaming. The episode also includes a Q&A segment with young listeners.

Enjoy this episode and get your PODucation on!! 

Introduction to the Science of Podcast

• Dahlia Sandoval introduces the podcast, emphasizing curiosity and the exploration of various scientific topics.
• The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.
• Partnerships include the UCSD Moores Cancer Center and the UCSD campus.
• Funding for the program is provided by Cloudcast Media.

Welcome and Episode Overview

• Dahlia Sandoval welcomes listeners and introduces the episode's focus on cell signaling and circuitry, particularly in relation to cancer cells.
• August is introduced as the co-host, along with August, Kelsey, and Josue.
• August introduces Dr. Sofia Cardenas-Alcoser, the guest speaker for the episode.

Dr. Sophia Cardenas-Alcoser’s Background

• Dr. Cardenas-Alcoser shares her journey from studying chemistry in Ecuador to pursuing biomedical research in Argentina.
• She discusses her acceptance into a master's program at the University of La Plata and her subsequent PhD at the University of Buenos Aires.
• Dr. Cardenas-Alcoser talks about her transition to the UCSD Moores Cancer Center and the challenges she faced as a first-generation researcher.

Personal Insights and Game Segment

• Dr. Cardenas-Alcoser shares her experiences of overcoming language barriers and personal challenges in her research journey.
• A fun game segment involves questions about her first science experiment, favorite music, and preferences for pets and food.
• Dr. Cardenas-Alcoser reveals her love for video games and her Twitch channel, where she streams games and discusses science.

Exploring Cell Signaling and Cancer Research

• Dr. Cardenas-Alcoser explains the concept of cell signaling using the analogy of a cell as an industry with different components.
• She describes the role of receptors and ligands in cell signaling and the importance of understanding these pathways.
• The discussion includes the significance of G protein-coupled receptors (GPCRs) and their role in cancer research.

Discoveries and Implications in Cancer Research

• Dr. Cardenas-Alcoser highlights a significant discovery about the role of G protein alpha subunits in cancer.
• She explains how the activation of specific G protein pathways can affect the immune system's response to tumors.
• The potential for using this discovery to develop new cancer treatments is discussed.

Challenges and Progress in Cancer Research

• Dr. Cardenas-Alcoser talks about the challenges of translating basic research into clinical applications.
• She shares a story about a dormant project that was revived due to new funding and its potential impact on treating fibrodysplasia.
• The discussion includes the importance of animal testing and the potential for using the same drug to treat certain cancers.

Audience Questions and Mentorship

• Audience questions cover the importance of mentorship in research and how to seek it.
• Dr. Cardenas-Alcoser emphasizes the role of mentors in guiding researchers through failures and teaching them how to think critically.
• She advises young researchers to be persistent and to seek opportunities in labs that align with their interests.

Managing Disappointment and Future of Cancer Research

• Dr. Cardenas-Alcoser discusses how to manage disappointment in the lab and the importance of learning from failures.
• She shares her vision for the future of cancer research, predicting that cancer will become more manageable and less deadly.
• The discussion includes the need for patience and continued interest in finding new treatments.

Final Thoughts and Contact Information

• Dr. Cardenas-Alcoser encourages young researchers to pursue their curiosity and not to be discouraged by a lack of background in research.
• She provides her contact information for those interested in reaching out to her for mentorship or further discussion.
• The episode concludes with thanks to the collaborators and listeners, and a teaser for the next episode's topic.

"The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Max Arola, Sasha Goldschmied, Josue Castillo, Evan Sosa, August Ou, and Kelsey Lewis. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. 

About Cloudcast Media

As the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST platform to help amplify, augment, and accelerate the mission and reach of community social impact organizations.  For more information on Cloudcast Media, please visit their website at CloudCast Media.  

About UCSD Moores Cancer Center

Established in 1978, Moores Cancer Center at UC San Diego Health is one of just 57 National Cancer Institute-Designated Comprehensive Cancer Centers in the United States, and the only one in the San Diego region. Such centers are prominent among the leading institutions in the nation dedicated to scientific innovation and clinical excellence. From research in molecular genetics to the most advanced treatments, Moores Cancer Center is at the forefront of the fight against cancer, developing promising new therapies and making them available to cancer patients throughout the region. Our cancer services were ranked #1 in San Diego, with 10 specialties ranking nationally by U.S. News & World Report in its 2023-2024 "Best Hospitals" survey. For more information, please visit https://moorescancercenter.ucsd.edu/.

About Jackie Robinson Family YMCA

The Jackie Robinson Family YMCA serves over 20,000 youth and families each year through a wide variety of educational, recreational and sports programs. In one of San Diego's most critical communities, we have a daily opportunity to make a significant impact on thousands of lives. YMCA programs teach kids character values and valuable skills that will help them grow into responsible, successful adults. For more information, please visit https://www.ymcasd.org/locations/jackie-robinson-family-ymca.

About the Elementary Institute of Science

The Elementary Institute of Science (EIS) is a nonprofit organization committed to increasing lifelong opportunities for students of southeast San Diego through science, technology, engineering and math (STEM) education. Our after-school, weekend and school partnership programs broaden access to quality STEM experiences, foster critical thinking, expand technical skills and encourage students to pursue STEM careers. For more information, please visit https://eisca.org/.

The episode was recorded by the students and engineered / mixed / mastered by Christelle Auzas.

Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.

In this episode, Riley James, Haydee Arancibia-Hardwick, and Margaux Stack-Babich from the UCSD Moores Cancer Center sit down to discuss THE SCIENCE OF MICROBES with Dr. David Gonzalez, an Associate Professor in Pharmacology at the Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, School of Medicine, as the Founder and Director for the Collaborative Center of Multiplexing Proteomics.  Dr. Gonzalez was on this episode joined by his sons, David Jr. and Isaiah, and a lab researcher, Yesenia, an alumna of UC-Riverside.  They discuss the importance of microbes, their roles in human health, and the impact of antibiotics on gut microbiomes. They highlight the potential of proteomics in understanding protein interactions and the need for alternative therapeutics. The conversation also touches on the personal and professional journeys of the participants, emphasizing the importance of education and perseverance in scientific careers.

Enjoy this episode and get your PODucation on!! 

"Rapid Fire" Warm-Up Round and Personal Introductions

• The guests participate in a rapid-fire warm-up round, answering questions about their first science experiments and favorite musicians.
• Dr. Gonzalez shares his first science experiment involving making plastic in a chemistry class, which sparked his interest in science.
• Isaiah, David Jr. and Yesenia share their first experiences with science projects 
• The guests discuss their favorite musicians, with from Tame Impala to Kendrick Lamar

Microbes and Their Importance

• Dr. Gonzalez explains the role of microbes as the gatekeepers of the world, contributing to oxygen production and metabolism in the gut.
• The conversation touches on the balance between good and bad microbes, with Dr. Gonzalez emphasizing that microbes can be both beneficial and harmful depending on context.
• The guests discuss the importance of the gut microbiome and its impact on human health, including the role of stool samples in microbiome research.
• Dr. Gonzalez highlights the advancements in microbiome research at UCSD and the importance of understanding the microbiome for future medical treatments.

Applications of Microbiome Research

• The guests discuss the potential of the gut microbiome in treating diseases and the role of probiotics and antibiotics in maintaining gut health.
• Dr. Gonzalez mentions the impact of antibiotics on the gut microbiome and the rise of antibiotic-resistant pathogens.
• The conversation shifts to the role of the microbiome in cancer treatment and the potential of immunotherapies.
• Dr. Gonzalez shares insights on the use of checkpoint inhibitors and the microbiome's influence on treatment efficacy.

Antibacterial and Antimicrobial Industry

• The guests address the challenges of antibacterial and antimicrobial products, emphasizing the need for awareness of antibiotic resistance.
• Dr. Gonzalez discusses the overuse of antibiotics and the importance of finding alternative therapeutic approaches, such as vaccines.
• The conversation highlights the role of proteomics in understanding the proteome and its applications in medical research.
• Dr. Gonzalez explains the power of proteomics in providing a comprehensive view of protein interactions and its potential in developing new drugs.

Impact of COVID-19 on Scientific Careers

• The guests share their personal experiences and the impact of COVID-19 on their scientific careers and educational paths.
• Isaiah discusses the challenges of gaining clinical experience during the pandemic and the importance of community outreach and education.
• David Jr. shares how COVID-19 led him to pursue a PhD in structural biology, focusing on emerging viruses.
• The guests emphasize the importance of resilience and adaptability in navigating career challenges during the pandemic.

Future of Microbiome Research and Personal Reflections

• The guests discuss their hopes for the future of microbiome research, including the development of alternative therapeutics and the continued advancements in proteomics.
• Dr. Gonzalez envisions a future where real-time health monitoring is possible through stool analysis.
• The guests reflect on the importance of education and mentorship in fostering scientific careers and the impact of their work on future generations.
• The conversation concludes with the guests sharing their admiration for each other and their commitment to continuing their scientific pursuits.

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